Compile Data Set for Download or QSAR
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Found 1994 with Last Name = 'therrien' and Initial = 'e'
TargetBeta-secretase 1 [1-453](Homo sapiens (Human))
Universite De Montreal At Succursale Centre-Ville

LigandPNGBDBM16047((4S)-4-[(2S)-2-[(2R,4S,5S)-5-[(2S)-2-[(2S)-2-[(4S)...)
Affinity DataIC50:  0.600nMpH: 4.5 T: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50301573((2S,3aS,7aS)-N-(4-carbamimidoylbenzyl)-1-((2S,3R)-...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50301562(CHEMBL584260 | N-(4-carbamimidoylbenzyl)-2-(1-(2-c...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50301571((2S,3aS,7aS)-N-(4-carbamimidoylbenzyl)-1-((2R,3R)-...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50301572((2S,3aS,7aS)-N-(4-carbamimidoylbenzyl)-1-((R)-3,3-...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50301574(CHEMBL568990 | Chlorodysinosin A)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universite De Montreal At Succursale Centre-Ville

LigandPNGBDBM16047((4S)-4-[(2S)-2-[(2R,4S,5S)-5-[(2S)-2-[(2S)-2-[(4S)...)
Affinity DataIC50:  6nMT: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50301559(CHEMBL569249 | N-(4-carbamimidoylbenzyl)-2-(1-(2,5...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50115202(CHEMBL3608550)
Affinity DataIC50:  7nMAssay Description:Inhibition of human c-Met kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50277188(CHEMBL473270 | N1-(biphenyl-3-yl)-N8-hydroxyoctane...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant N-terminal histidine-tagged HDAC6 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50277188(CHEMBL473270 | N1-(biphenyl-3-yl)-N8-hydroxyoctane...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant C-terminal FLAG-tagged HDAC1 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universite De Montreal At Succursale Centre-Ville

LigandPNGBDBM16055((2S)-N-[(1S)-1-{[(1S,2S)-1-[(1R,2R)-2-{[(1S)-1-(bu...)
Affinity DataIC50: <10nMT: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50317323(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human RONMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50115203(CHEMBL3608551)
Affinity DataIC50:  10nMAssay Description:Inhibition of human c-Met kinase domainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50091030(CHEMBL3582033)
Affinity DataIC50:  10nMAssay Description:Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universite De Montreal At Succursale Centre-Ville

LigandPNGBDBM16054((2S)-N-[(1S)-1-{[(1S,2S)-1-[(1R,2R)-2-{[(1S)-1-(bu...)
Affinity DataIC50: <10nMT: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universite De Montreal At Succursale Centre-Ville

LigandPNGBDBM16049((4S)-4-[(2S)-2-{[(1R,2R)-2-[(1S,2S)-2-[(2S)-2-[(2S...)
Affinity DataIC50: <10nMT: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1 [1-453](Homo sapiens (Human))
Universite De Montreal At Succursale Centre-Ville

LigandPNGBDBM16060((2R,3R)-3-[(1S,2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4...)
Affinity DataIC50: <10nMpH: 4.5 T: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1 [1-453](Homo sapiens (Human))
Universite De Montreal At Succursale Centre-Ville

LigandPNGBDBM16057((2S)-N-[(1S)-1-{[(1S,2S)-1-[(1R,2R)-2-{[(1S)-1-(bu...)
Affinity DataIC50:  10nMpH: 4.5 T: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50301561(CHEMBL565328 | N-(4-carbamimidoylbenzyl)-2-(1-(2,5...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50301558(CHEMBL565292 | N-(4-carbamimidoylbenzyl)-2-(1-(3-m...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50317323(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human RONMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1 [1-453](Homo sapiens (Human))
Universite De Montreal At Succursale Centre-Ville

LigandPNGBDBM16048((4S)-4-amino-4-{[(1S)-1-{[(1S)-2-carbamoyl-1-{[(1R...)
Affinity DataIC50:  12nMpH: 4.5 T: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50317323(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human c-MetMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50317323(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50:  12nMAssay Description:Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50090969(CHEMBL3582034)
Affinity DataIC50:  13nMAssay Description:Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50115203(CHEMBL3608551)
Affinity DataIC50:  14nMAssay Description:Inhibition of human RONMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50317324(CHEMBL1087984 | N-(4-(6,7-dimethoxyquinolin-4-ylox...)
Affinity DataIC50:  16nMAssay Description:Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50177433(CHEMBL535160 | N-(4-carbamimidoylbenzyl)-2-(2-hydr...)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1 [1-453](Homo sapiens (Human))
Universite De Montreal At Succursale Centre-Ville

LigandPNGBDBM16049((4S)-4-[(2S)-2-{[(1R,2R)-2-[(1S,2S)-2-[(2S)-2-[(2S...)
Affinity DataIC50:  16nMpH: 4.5 T: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50177436(CHEMBL557787 | N-(4-carbamimidoyl-benzyl)-2-[2-hyd...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50090968(CHEMBL3582035)
Affinity DataIC50:  17nMAssay Description:Inhibition of RON (unknown origin) transfected in 293T cells assessed as autophosporylated level by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50119079((6R,8aS)-6-Benzyl-6-hydroxy-5-oxo-octahydro-indoli...)
Affinity DataIC50:  20nMAssay Description:Compound was tested for inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50119079((6R,8aS)-6-Benzyl-6-hydroxy-5-oxo-octahydro-indoli...)
Affinity DataIC50:  20nMAssay Description:Compound was tested for inhibitory activity against ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50115196(CHEMBL3608549)
Affinity DataIC50:  23nMAssay Description:Inhibition of human RONMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50235535(CHEMBL559192 | N-(4-carbamimidoyl-benzyl)-2-[4-met...)
Affinity DataIC50:  23nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50115201(CHEMBL3608544)
Affinity DataIC50:  23nMAssay Description:Inhibition of human RONMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50115197(CHEMBL3608547)
Affinity DataIC50:  25nMAssay Description:Inhibition of human RONMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1 [1-453](Homo sapiens (Human))
Universite De Montreal At Succursale Centre-Ville

LigandPNGBDBM16055((2S)-N-[(1S)-1-{[(1S,2S)-1-[(1R,2R)-2-{[(1S)-1-(bu...)
Affinity DataIC50:  25nMpH: 4.5 T: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Universite De Montreal At Succursale Centre-Ville

LigandPNGBDBM16053((2S)-2-{[(1R,2R)-2-[(1S,2S)-2-[(2S)-2-[(2S)-2-acet...)
Affinity DataIC50:  25nMT: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50177425(CHEMBL537420 | N-(4-carbamimidoylbenzyl)-2-(3-(2,5...)
Affinity DataIC50:  25nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50115202(CHEMBL3608550)
Affinity DataIC50:  27nMAssay Description:Inhibition of human RONMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50294877((2R,3AS,6R,7AS)-N-(2-{1-[AMINO(IMINO)METHYL]-2,5-D...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50114398(CHEMBL3609808)
Affinity DataIC50:  30nMAssay Description:Inhibition of human RONMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50317323(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50:  30nMAssay Description:Inhibition of RON phosphorylation in human PC3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50317323(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)
Affinity DataIC50:  30nMAssay Description:Inhibition of RON phosphorylation in human HT29 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50115200(CHEMBL3608545)
Affinity DataIC50:  32nMAssay Description:Inhibition of human RONMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Laboratoires Chemrf Inc/Chemrf Laboratories

Curated by ChEMBL
LigandPNGBDBM50114396(CHEMBL3609807)
Affinity DataIC50:  34nMAssay Description:Inhibition of human RONMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50177421(CHEMBL558235 | N-(4-carbamimidoylbenzyl)-2-(3-(3,4...)
Affinity DataIC50:  39nMAssay Description:Inhibitory activity against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1 [1-453](Homo sapiens (Human))
Universite De Montreal At Succursale Centre-Ville

LigandPNGBDBM16051((4S)-4-amino-4-{[(1S)-1-{[(1S)-2-carbamoyl-1-{[(1S...)
Affinity DataIC50:  39nMpH: 4.5 T: 2°CAssay Description:Inhibition assays were done in black 96-well plates by adding test compounds to the respective enzyme in assay buffer. Plates were incubated at room ...More data for this Ligand-Target Pair
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