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Found 2917 with Last Name = 'tomlinson' and Initial = 'e'
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304826((S)-7-(2-chlorophenoxy)-2-((R)-2-methylpiperazin-1...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]5HT from human 5HT2C receptor expressed in mouse 3T3 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304805((S)-7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dih...)
Affinity DataKi:  0.700nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304802((S)-8-(2-chlorophenoxy)-2-(piperazin-1-yl)-5,6,7,8...)
Affinity DataKi:  0.700nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50380913(CHEMBL2016732)
Affinity DataKi:  0.700nMAssay Description:Displacement of [125I]PPY from human recombinant NPYY5 receptor expressed in insect Sf9 membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50380915(CHEMBL2016682)
Affinity DataKi:  0.800nMAssay Description:Displacement of [125I]PPY from human recombinant NPYY5 receptor expressed in insect Sf9 membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314613((S)-N-(4-(4,4-dimethylcyclohexyloxy)-5-fluoro-2-me...)
Affinity DataKi:  0.900nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304804(7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dihydro...)
Affinity DataKi:  0.900nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50380923(CHEMBL2016740)
Affinity DataKi:  0.900nMAssay Description:Displacement of [125I]PPY from human recombinant NPYY5 receptor expressed in insect Sf9 membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304808(4-chloro-2-(piperazin-1-yl)thieno[2,3-d]pyrimidine...)
Affinity DataKi:  1nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304805((S)-7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dih...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50380922(CHEMBL2016739)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]PPY from human recombinant NPYY5 receptor expressed in insect Sf9 membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50123737(3-{2-[6-(2-tert-Butoxy-ethoxy)-pyridin-3-yl]-3H-im...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [125I]PPY from human recombinant NPYY5 receptor expressed in insect Sf9 membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304807((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...)
Affinity DataKi:  1.5nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304802((S)-8-(2-chlorophenoxy)-2-(piperazin-1-yl)-5,6,7,8...)
Affinity DataKi:  1.5nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304300(CHEMBL595573 | trans-N-[1-(2-fluorophenyl)-3-pyraz...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I]PPY from human recombinant NPYY5 receptor expressed in insect Sf9 membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314616((S)-N-(4-(cyclohexylmethoxy)-5-fluoro-2-methoxyben...)
Affinity DataKi:  1.70nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314614((S)-N-(4-(4,4-dimethylcyclohexyloxy)-2,5-difluorob...)
Affinity DataKi:  1.80nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304803((R)-8-(2-chlorophenoxy)-2-(piperazin-1-yl)-5,6,7,8...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50380920(CHEMBL2016737)
Affinity DataKi:  2.40nMAssay Description:Displacement of [125I]PPY from human recombinant NPYY5 receptor expressed in insect Sf9 membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304827((S)-7-(3-fluorophenoxy)-2-(piperazin-1-yl)-6,7-dih...)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]5HT from human 5HT2C receptor expressed in mouse 3T3 cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304804(7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dihydro...)
Affinity DataKi:  3.80nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314618(CHEMBL1090397 | N-((4'-chloro-3-fluorobiphenyl-4-y...)
Affinity DataKi:  4nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304809(4-(3-chlorobenzyloxy)-2-(piperazin-1-yl)thieno[2,3...)
Affinity DataKi:  4nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314623((S)-N-(4-cyclohexylbenzyl)pyrrolidine-2-carboxamid...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304807((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...)
Affinity DataKi:  4.40nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50380925(CHEMBL2016742)
Affinity DataKi:  4.60nMAssay Description:Displacement of [125I]PPY from human recombinant NPYY5 receptor expressed in insect Sf9 membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50380914(S-2367 | VELNEPERIT)
Affinity DataKi:  5nMAssay Description:Displacement of [125I]PPY from human recombinant NPYY5 receptor expressed in insect Sf9 membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304801((S)-7-(2,5-difluorobenzyloxy)-2-((R)-2-methylpiper...)
Affinity DataKi:  7nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304807((S)-7-(5-fluoro-2-methylbenzyloxy)-2-((R)-2-methyl...)
Affinity DataKi:  7.70nMAssay Description:Displacement of [125I]DOI from human 5HT2B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50380919(CHEMBL2016736)
Affinity DataKi:  8nMAssay Description:Displacement of [125I]PPY from human recombinant NPYY5 receptor expressed in insect Sf9 membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314624((S)-N-((3',5'-dichlorobiphenyl-4-yl)methyl)pyrroli...)
Affinity DataKi:  8nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50380918(CHEMBL2016735)
Affinity DataKi:  10nMAssay Description:Displacement of [125I]PPY from human recombinant NPYY5 receptor expressed in insect Sf9 membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304803((R)-8-(2-chlorophenoxy)-2-(piperazin-1-yl)-5,6,7,8...)
Affinity DataKi:  10nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50380926(CHEMBL2016743)
Affinity DataKi:  11nMAssay Description:Displacement of [125I]PPY from human recombinant NPYY5 receptor expressed in insect Sf9 membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314613((S)-N-(4-(4,4-dimethylcyclohexyloxy)-5-fluoro-2-me...)
Affinity DataKi:  12.8nMAssay Description:Binding affinity to 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314614((S)-N-(4-(4,4-dimethylcyclohexyloxy)-2,5-difluorob...)
Affinity DataKi:  13.7nMAssay Description:Binding affinity to 5HT2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50016970(4-Piperazin-1-yl-thieno[3,2-c]pyridine; hydrochlor...)
Affinity DataKi:  14nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304800((S)-7-(2,5-difluorobenzyloxy)-2-(piperazin-1-yl)-6...)
Affinity DataKi:  15nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304801((S)-7-(2,5-difluorobenzyloxy)-2-((R)-2-methylpiper...)
Affinity DataKi:  16nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304806((R)-7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dih...)
Affinity DataKi:  20nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314626((S)-N-(4-(benzyloxy)benzyl)pyrrolidine-2-carboxami...)
Affinity DataKi:  20nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304820(2-(piperazin-1-yl)-5,6,7,8-tetrahydroquinoline | C...)
Affinity DataKi:  21nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50016972(4-Piperazin-1-yl-furo[3,2-c]pyridine; hydrochlorid...)
Affinity DataKi:  22nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuropeptide Y receptor type 5(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50380916(CHEMBL2016733)
Affinity DataKi:  22nMAssay Description:Displacement of [125I]PPY from human recombinant NPYY5 receptor expressed in insect Sf9 membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304812(4-methoxy-2-(piperazin-1-yl)-5,6,7,8-tetrahydroqui...)
Affinity DataKi:  23nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314625((S)-N-(4-(3-fluorophenoxy)benzyl)pyrrolidine-2-car...)
Affinity DataKi:  23nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50314615((S)-N-(3,5-difluoro-4-((1s,4s)-4-methylcyclohexylo...)
Affinity DataKi:  25nMAssay Description:Binding affinity to 5HT2C receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304800((S)-7-(2,5-difluorobenzyloxy)-2-(piperazin-1-yl)-6...)
Affinity DataKi:  25nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304818(4-(3-chlorobenzyloxy)-2-(piperazin-1-yl)thieno[3,2...)
Affinity DataKi:  28nMAssay Description:Agonist activity against human 5HT2C receptor by FLIPR assay relative to 5HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50304806((R)-7-(2-chlorophenoxy)-2-(piperazin-1-yl)-6,7-dih...)
Affinity DataKi:  41nMAssay Description:Displacement of [125I]DOI from rat 5HT2A receptor expressed in mouse 3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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