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Found 379 with Last Name = 'tucker' and Initial = 'gc'
TargetInterstitial collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM30344(Cipemastat | Trocade)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of Matrix metalloprotease-1 (MMP1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096646(2-(4'-Chloro-biphenyl-4-yloxymethyl)-N-hydroxy-4-(...)
Affinity DataIC50:  0.0160nMAssay Description:Inhibition of Matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50131941(2-(4'-Chloro-biphenyl-4-ylsulfanylmethyl)-N-hydrox...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibitory activity against matrix metalloprotease-2 (MMP2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50313793((S)-3-(3-amino-4-(3-(5,6,7,8-tetrahydro-1,8-naphth...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human integrin alphav beta3 receptor by biotinylated vitronectin competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50120519((7-{[4-(1,4,5,6-Tetrahydro-pyrimidin-2-ylamino)-bu...)
Affinity DataIC50:  0.100nMAssay Description:Displacement of vitronectin from Human integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096646(2-(4'-Chloro-biphenyl-4-yloxymethyl)-N-hydroxy-4-(...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50078569((S)-4-(Biphenyl-4-ylmethylsulfanyl)-N-hydroxy-2-[i...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50078565((S)-2-[(Biphenyl-4-sulfonyl)-isobutyl-amino]-N-hyd...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50120519((7-{[4-(1,4,5,6-Tetrahydro-pyrimidin-2-ylamino)-bu...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of vitronectin from Human integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50120520((7-{[4-(4,5-Dihydro-1H-imidazol-2-ylamino)-butyryl...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of fibrinogen from Human integrin alphaIIb-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50120517(CHEMBL109703 | {7-[(4-5,6,7,8-Tetrahydro-[1,8]naph...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of fibrinogen from Human integrin alphaIIb-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50120520((7-{[4-(4,5-Dihydro-1H-imidazol-2-ylamino)-butyryl...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of vitronectin from human integrin alphaV-beta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50120517(CHEMBL109703 | {7-[(4-5,6,7,8-Tetrahydro-[1,8]naph...)
Affinity DataIC50:  0.300nMAssay Description:Displacement of vitronectin from human integrin alphaV-beta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50378338(CHEMBL573961)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human integrin alphav beta3 receptor by biotinylated vitronectin competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50378336(CHEMBL574136)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human integrin alphav beta3 receptor by biotinylated vitronectin competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096651(2-(4'-Cyano-biphenyl-4-yloxymethyl)-N-hydroxy-4-(4...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against matrix metalloprotease-2 (MMP2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096649(2-(Biphenyl-4-yloxymethyl)-N-hydroxy-4-(4-oxo-4H-b...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50120523((7-{[4-(1H-Benzoimidazol-2-ylamino)-butyrylamino]-...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of vitronectin from human integrin alphaV-beta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50378330(CHEMBL583966)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human integrin alphav beta3 receptor by biotinylated vitronectin competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Mus musculus)
Universit£

Curated by ChEMBL
LigandPNGBDBM50078571((R)-2-[[(Benzhydryl-carbamoyl)-methyl]-(4-methoxy-...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory concentration required against matrix metalloprotease-9 (MMP-9 gelatinase B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50131941(2-(4'-Chloro-biphenyl-4-ylsulfanylmethyl)-N-hydrox...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP9)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50096651(2-(4'-Cyano-biphenyl-4-yloxymethyl)-N-hydroxy-4-(4...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50096651(2-(4'-Cyano-biphenyl-4-yloxymethyl)-N-hydroxy-4-(4...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50096646(2-(4'-Chloro-biphenyl-4-yloxymethyl)-N-hydroxy-4-(...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50378335(CHEMBL574135)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human integrin alphav beta3 receptor by biotinylated vitronectin competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50120523((7-{[4-(1H-Benzoimidazol-2-ylamino)-butyrylamino]-...)
Affinity DataIC50:  0.600nMAssay Description:Displacement of vitronectin from human integrin alphaV-beta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50378326(CHEMBL568500)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human integrin alphav beta3 receptor by biotinylated vitronectin competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50378327(CHEMBL575868)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human integrin alphav beta3 receptor by biotinylated vitronectin competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50378337(CHEMBL584588)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human integrin alphav beta3 receptor by biotinylated vitronectin competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50078565((S)-2-[(Biphenyl-4-sulfonyl)-isobutyl-amino]-N-hyd...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50078566((S)-4-Benzylsulfanyl-N-hydroxy-2-[isobutyl-(4-meth...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50078566((S)-4-Benzylsulfanyl-N-hydroxy-2-[isobutyl-(4-meth...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of matrix metalloprotease-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50378329(CHEMBL573907)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human integrin alphav beta3 receptor by biotinylated vitronectin competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50120516((7-{[4-(Pyridin-2-ylamino)-butyrylamino]-methyl}-6...)
Affinity DataIC50:  0.800nMAssay Description:Displacement of fibrinogen from Human integrin alphaIIb-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50378323(CHEMBL565478)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human integrin alphav beta3 receptor by biotinylated vitronectin competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50120518((7-{[5-(Pyridin-2-ylamino)-pentanoylamino]-methyl}...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of fibrinogen from Human integrin alphaIIb-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50378328(CHEMBL573683)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human integrin alphav beta3 receptor by biotinylated vitronectin competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50096649(2-(Biphenyl-4-yloxymethyl)-N-hydroxy-4-(4-oxo-4H-b...)
Affinity DataIC50:  1nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50452012(CHEMBL2110187)
Affinity DataIC50:  1nMAssay Description:Inhibition of farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity against matrix metalloprotease-3 (MMP3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50096651(2-(4'-Cyano-biphenyl-4-yloxymethyl)-N-hydroxy-4-(4...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50378334(CHEMBL566776)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human integrin alphav beta3 receptor by biotinylated vitronectin competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50082556((S)-2,2-Dimethyl-4-[4-(pyridin-4-yloxy)-benzenesul...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of Matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Institut De Recherches Servier

Curated by ChEMBL
LigandPNGBDBM50131941(2-(4'-Chloro-biphenyl-4-ylsulfanylmethyl)-N-hydrox...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against matrix metalloprotease-13 (MMP13)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Universite Catholique De Louvain

Curated by ChEMBL
LigandPNGBDBM50378324(CHEMBL567645)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human integrin alphav beta3 receptor by biotinylated vitronectin competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50131944(2-(4-Oxo-4H-benzo[d][1,2,3]triazin-3-ylmethyl)-5-(...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity against matrix metalloprotease-3 (MMP3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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