Affinity DataKi: 50nMAssay Description:Competitive inhibition of human SETD8 (186 to 352 residues) using biotin-labeled H4K20 (1 to 24 residues) as substrate after 1 hr in presence of 3H-S...More data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Competitive inhibition of SETD8 (unknown origin) using biotin-labeled H4 (1 to 24 residues) as substrate after 1 hr in presence of varying levels of ...More data for this Ligand-Target Pair
Affinity DataKi: 2.20E+4nMAssay Description:Competitive inhibition assay using human and rat MAOs.More data for this Ligand-Target Pair
Affinity DataKi: 1.07E+5nMAssay Description:Competitive inhibition assay using human and rat MAOs.More data for this Ligand-Target Pair
Affinity DataKi: 1.51E+5nMAssay Description:Competitive inhibition assay using human and rat MAOs.More data for this Ligand-Target Pair
Affinity DataKi: 1.70E+5nMAssay Description:Inhibition of H3(1-10)K4me3 peptide binding to thrombin cleavable N-terminal 6His tagged and 13C-IVLM labeled human KDM4A tandem TUDOR domain (897 to...More data for this Ligand-Target Pair
Affinity DataKi: 2.12E+5nMAssay Description:Competitive inhibition assay using human and rat MAOs.More data for this Ligand-Target Pair
Affinity DataIC50: 25nMpH: 8.0 T: 2°CAssay Description:Experiments were performed in triplicate at room temperature with 1 h incubation of 10 μl reaction mixture in buffer of 20 mM Tris-HCl, pH 8.0, ...More data for this Ligand-Target Pair
Affinity DataIC50: 41nMAssay Description:Inhibition of C-terminal 8-His tagged wild type human IDH1 (1 to 414 residues) expressed in Escherichia coli BL21(DE3)-T1R preincubated for 15 mins u...More data for this Ligand-Target Pair
Affinity DataIC50: 82nMAssay Description:Inhibition of C-terminal 8-His tagged wild type human IDH1 (1 to 414 residues) expressed in Escherichia coli BL21(DE3)-T1R preincubated for 15 mins u...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of C-terminal 8-His tagged wild type human IDH1 (1 to 414 residues) expressed in Escherichia coli BL21(DE3)-T1R preincubated for 15 mins u...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of C-terminal 8-His tagged wild type human IDH1 (1 to 414 residues) expressed in Escherichia coli BL21(DE3)-T1R preincubated for 15 mins u...More data for this Ligand-Target Pair
Affinity DataIC50: 144nMpH: 8.0 T: 2°CAssay Description:Experiments were performed in triplicate at room temperature with 1 h incubation of 10 μl reaction mixture in buffer of 20 mM Tris-HCl, pH 8.0, ...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Inhibition of C-terminal 8-His tagged wild type human IDH1 (1 to 414 residues) expressed in Escherichia coli BL21(DE3)-T1R preincubated for 15 mins u...More data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Inhibition of C-terminal 8-His tagged wild type human IDH1 (1 to 414 residues) expressed in Escherichia coli BL21(DE3)-T1R preincubated for 15 mins u...More data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Inhibition of human SETD8 (186 to 352 residues) using biotin-labeled H4K20 (1 to 24 residues) as substrate after 1 hr in presence of 3H-SAM by scinti...More data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Inhibition of C-terminal 8-His tagged wild type human IDH1 (1 to 414 residues) expressed in Escherichia coli BL21(DE3)-T1R preincubated for 15 mins u...More data for this Ligand-Target Pair
Affinity DataIC50: 590nMpH: 8.0 T: 2°CAssay Description:Experiments were performed in triplicate at room temperature with 1 h incubation of 10 μl reaction mixture in buffer of 20 mM Tris-HCl, pH 8.0, ...More data for this Ligand-Target Pair
Affinity DataIC50: 970nMAssay Description:Inhibition of C-terminal 8-His tagged wild type human IDH1 (1 to 414 residues) expressed in Escherichia coli BL21(DE3)-T1R preincubated for 15 mins u...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMpH: 8.0 T: 2°CAssay Description:Experiments were performed in triplicate at room temperature with 1 h incubation of 10 μl reaction mixture in buffer of 20 mM Tris-HCl, pH 8.0, ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of C-terminal 8-His tagged wild type human IDH1 (1 to 414 residues) expressed in Escherichia coli BL21(DE3)-T1R preincubated for 15 mins u...More data for this Ligand-Target Pair
Affinity DataIC50: 1.77E+3nMAssay Description:Inhibition of C-terminal 8-His tagged wild type human IDH1 (1 to 414 residues) expressed in Escherichia coli BL21(DE3)-T1R preincubated for 15 mins u...More data for this Ligand-Target Pair
TargetGeranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign
Curated by ChEMBL
University Of Illinois At Urbana-Champaign
Curated by ChEMBL
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human geranylgeranyl diphosphate synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 4.80E+3nMpH: 8.0 T: 2°CAssay Description:Experiments were performed in triplicate at room temperature with 1 h incubation of 10 μl reaction mixture in buffer of 20 mM Tris-HCl, pH 8.0, ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.90E+3nMpH: 8.0 T: 2°CAssay Description:Experiments were performed in triplicate at room temperature with 1 h incubation of 10 μl reaction mixture in buffer of 20 mM Tris-HCl, pH 8.0, ...More data for this Ligand-Target Pair
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of SETD8 (unknown origin) using biotin-labeled H4 (1 to 24 residues) as substrate after 1 hr in presence of [3H]SAM by scintillation proxi...More data for this Ligand-Target Pair
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of C-terminal 8-His tagged wild type human IDH1 (1 to 414 residues) expressed in Escherichia coli BL21(DE3)-T1R preincubated for 15 mins u...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMpH: 8.0 T: 2°CAssay Description:Experiments were performed in triplicate at room temperature with 1 h incubation of 10 μl reaction mixture in buffer of 20 mM Tris-HCl, pH 8.0, ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-terminal 8-His tagged wild type human IDH1 (1 to 414 residues) expressed in Escherichia coli BL21(DE3)-T1R preincubated for 15 mins u...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of C-terminal 8-His tagged wild type human IDH1 (1 to 414 residues) expressed in Escherichia coli BL21(DE3)-T1R preincubated for 15 mins u...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMpH: 8.0 T: 2°CAssay Description:Experiments were performed in triplicate at room temperature with 1 h incubation of 10 μl reaction mixture in buffer of 20 mM Tris-HCl, pH 8.0, ...More data for this Ligand-Target Pair
TargetSqualene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign
Curated by ChEMBL
University Of Illinois At Urbana-Champaign
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human SQSMore data for this Ligand-Target Pair
TargetSqualene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign
Curated by ChEMBL
University Of Illinois At Urbana-Champaign
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human SQSMore data for this Ligand-Target Pair
TargetSqualene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign
Curated by ChEMBL
University Of Illinois At Urbana-Champaign
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human SQSMore data for this Ligand-Target Pair
Target4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign
Curated by ChEMBL
University Of Illinois At Urbana-Champaign
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Staphylococcus aureus CrtMMore data for this Ligand-Target Pair
Target4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign
Curated by ChEMBL
University Of Illinois At Urbana-Champaign
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Staphylococcus aureus CrtMMore data for this Ligand-Target Pair
Target4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign
Curated by ChEMBL
University Of Illinois At Urbana-Champaign
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Staphylococcus aureus CrtMMore data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Csir-Central Drug Research Institute
Curated by ChEMBL
Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataEC50: 2.75E+3nMAssay Description:Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assa...More data for this Ligand-Target Pair
Affinity DataKd: 1.27E+5nMAssay Description:Binding affinity to 6His-tagged and human KDM4B tandem TUDOR domain (916 to 1030 residues) expressed in Escherichia coli BL21(DE3)-T1R by ITC methodMore data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Csir-Central Drug Research Institute
Curated by ChEMBL
Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataEC50: 457nMAssay Description:Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assa...More data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Csir-Central Drug Research Institute
Curated by ChEMBL
Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataEC50: 232nMAssay Description:Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assa...More data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Csir-Central Drug Research Institute
Curated by ChEMBL
Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataEC50: 2.73E+3nMAssay Description:Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assa...More data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Csir-Central Drug Research Institute
Curated by ChEMBL
Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataEC50: 11nMAssay Description:Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated c...More data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Csir-Central Drug Research Institute
Curated by ChEMBL
Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataEC50: 30nMAssay Description:Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated c...More data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Csir-Central Drug Research Institute
Curated by ChEMBL
Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataEC50: 21nMAssay Description:Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated c...More data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Csir-Central Drug Research Institute
Curated by ChEMBL
Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataEC50: 454nMAssay Description:Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assa...More data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Csir-Central Drug Research Institute
Curated by ChEMBL
Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataEC50: 1.69E+3nMAssay Description:Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assa...More data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Csir-Central Drug Research Institute
Curated by ChEMBL
Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataEC50: 31nMAssay Description:Agonist activity at human GPR109a expressed in HEK293 cells harboring glosensor-22F cAMP plasmid DNA assessed as inhibition of forskolin-stimulated c...More data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Csir-Central Drug Research Institute
Curated by ChEMBL
Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataEC50: 275nMAssay Description:Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assa...More data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Csir-Central Drug Research Institute
Curated by ChEMBL
Csir-Central Drug Research Institute
Curated by ChEMBL
Affinity DataEC50: 1.02E+3nMAssay Description:Agonist activity at human GPR109a expressed in HTLA cells assessed as increase in beta-arrestin2 recruitment after overnight incubation by Tango assa...More data for this Ligand-Target Pair