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Found 1847 with Last Name = 'vaccaro' and Initial = 'w'
TargetHistamine H3 receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175843(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175828(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM11863(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Affinity DataKi:  0.220nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160851(4-[4-(2,6,8,10-Tetraoxo-1,7,9-triaza-spiro[4.5]dec...)
Affinity DataKi:  0.230nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348414(CHEMBL1800984)
Affinity DataKi:  0.300nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160843(1-[4-(4-Phenoxy-phenoxy)-phenyl]-1,7,9-triaza-spir...)
Affinity DataKi:  0.330nMAssay Description:Inhibition of matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348407(CHEMBL1801006)
Affinity DataKi:  0.400nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348412(CHEMBL1800982)
Affinity DataKi:  0.400nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175843(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in human brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175833(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160852(4-ethyl-1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4....)
Affinity DataKi:  0.400nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160852(4-ethyl-1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4....)
Affinity DataKi:  0.400nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM22542(4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160855(1-[4-(4-chloro-phenoxy)-phenyl]-1,7,9-triaza-spiro...)
Affinity DataKi:  0.430nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM11863(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Affinity DataKi:  0.520nMAssay Description:Binding affinity for matrix metalloproteinase 13More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160852(4-ethyl-1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4....)
Affinity DataKi:  0.540nMAssay Description:Binding affinity for matrix metalloproteinase 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160852(4-ethyl-1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4....)
Affinity DataKi:  0.540nMAssay Description:Binding affinity for matrix metalloproteinase 13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM11863(4-({[4-(4-chlorophenoxy)benzene]sulfonyl}methyl)-N...)
Affinity DataKi:  0.550nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348404(CHEMBL1801009)
Affinity DataKi:  0.600nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348411(CHEMBL1800981)
Affinity DataKi:  0.700nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348405(CHEMBL1801008)
Affinity DataKi:  0.700nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160855(1-[4-(4-chloro-phenoxy)-phenyl]-1,7,9-triaza-spiro...)
Affinity DataKi:  0.720nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160851(4-[4-(2,6,8,10-Tetraoxo-1,7,9-triaza-spiro[4.5]dec...)
Affinity DataKi:  0.720nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348415(CHEMBL1800985)
Affinity DataKi:  0.800nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160852(4-ethyl-1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4....)
Affinity DataKi:  0.870nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50249196((15R)-8-cyano-15-methyl-N-(1,3-thiazol-2-yl)tetrac...)
Affinity DataKi:  0.900nMAssay Description:Displacement of FITC-dexamethasone from human recombinant glucocorticoid receptor alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348408(CHEMBL1801005)
Affinity DataKi:  0.900nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160855(1-[4-(4-chloro-phenoxy)-phenyl]-1,7,9-triaza-spiro...)
Affinity DataKi:  0.950nMAssay Description:Inhibition of matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50177543(1-(3-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-y...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from guinea pig histamine H3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
Affinity DataKi:  1nMAssay Description:Displacement of FITC-dexamethasone from human recombinant glucocorticoid receptor alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50249150(8,15-dimethyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6.2...)
Affinity DataKi:  1nMAssay Description:Displacement of FITC-dexamethasone from human recombinant glucocorticoid receptor alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataKi:  1.10nMAssay Description:Displacement of FITC-dexamethasone from human recombinant glucocorticoid receptor alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataKi:  1.10nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348410(CHEMBL1801004)
Affinity DataKi:  1.20nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50348401(CHEMBL1801012)
Affinity DataKi:  1.20nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160849(4-[4-(2,6,8,10-Tetraoxo-1,7,9-triaza-spiro[4.5]dec...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50249193((15R)-15-methyl-N-(1,3-thiazol-2-yl)tetracyclo[6.6...)
Affinity DataKi:  1.30nMAssay Description:Displacement of FITC-dexamethasone from human recombinant glucocorticoid receptor alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50249195(8,15-dimethyl-N-(1,3,4-thiadiazol-2-yl)tetracyclo[...)
Affinity DataKi:  1.30nMAssay Description:Displacement of FITC-dexamethasone from human recombinant glucocorticoid receptor alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50249195(8,15-dimethyl-N-(1,3,4-thiadiazol-2-yl)tetracyclo[...)
Affinity DataKi:  1.30nMAssay Description:Displacement of FITC-dexamethasone from human recombinant glucocorticoid receptor alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataKi:  1.5nMAssay Description:Displacement of FITC-dexamethasone from human recombinant glucocorticoid receptor alpha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetGlucocorticoid receptor(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataKi:  1.5nMAssay Description:Displacement of GS-red from GRapha by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target72 kDa type IV collagenase(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160847(1-(4-phenoxy-phenyl)-1,7,9-triaza-spiro[4.5]decane...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175833(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in human brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160843(1-[4-(4-Phenoxy-phenoxy)-phenyl]-1,7,9-triaza-spir...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of matrix metalloprotease-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160843(1-[4-(4-Phenoxy-phenoxy)-phenyl]-1,7,9-triaza-spir...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of matrix metalloprotease-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50160848(1-[4-(3-Methoxy-phenoxy)-phenyl]-1,7,9-triaza-spir...)
Affinity DataKi:  1.90nMAssay Description:Inhibition of matrix metalloprotease-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175828(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-(...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in human brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175827(4-((1H-imidazol-4-yl)methyl)-1-heptylpiperidine | ...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175851(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)-N-p...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(GUINEA PIG)
The Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50175846(4-((1H-imidazol-4-yl)methyl)-1-(3-(3-chlorophenoxy...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-N-alpha-methylhistamine from histamine H3 receptor in guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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