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Found 248 with Last Name = 'vaillancourt' and Initial = 'jp'
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10675((3S)-3-[(2S)-2-[(2S)-2-[(3S)-3-formamido-3-(phenyl...)
Affinity DataIC50:  1.80nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203364(CHEMBL248310 | N-((S)-3-(2-(3-(1H-tetrazol-5-ylami...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10551((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[2-(5-bromo-2-me...)
Affinity DataIC50:  5nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10674((3S)-5-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}...)
Affinity DataIC50:  5nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10671((3S)-3-[(2S)-2-{1-[5-(carboxymethoxy)-2-ethoxyphen...)
Affinity DataIC50:  5nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM50203361((3S)-3-(2-(3-(1H-tetrazol-5-ylamino)-5-tert-butyl-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM50203364(CHEMBL248310 | N-((S)-3-(2-(3-(1H-tetrazol-5-ylami...)
Affinity DataIC50:  6.60nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203361((3S)-3-(2-(3-(1H-tetrazol-5-ylamino)-5-tert-butyl-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10653((3S)-5-[(2-CHLORO-6-FLUOROBENZYL)SULFANYL]-3-{[N-(...)
Affinity DataIC50:  8nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
TargetCaspase-7(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10675((3S)-3-[(2S)-2-[(2S)-2-[(3S)-3-formamido-3-(phenyl...)
Affinity DataIC50:  8.40nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203361((3S)-3-(2-(3-(1H-tetrazol-5-ylamino)-5-tert-butyl-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant caspase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10554((3S)-5-(benzylsulfanyl)-3-[(2S)-2-{1-[2-methoxy-5-...)
Affinity DataIC50:  9nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10552((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-acetyl-2-m...)
Affinity DataIC50:  10nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10555((3S)-5-(benzylsulfanyl)-3-[(2S)-2-{2-hydroxy-2-[2-...)
Affinity DataIC50:  12nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10552((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-acetyl-2-m...)
Affinity DataIC50:  13nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM50160976((3S)-3-(2-(5-tert-butyl-3-((4-methyl-1,2,5-oxadiaz...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203361((3S)-3-(2-(3-(1H-tetrazol-5-ylamino)-5-tert-butyl-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant caspase 8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10556((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[2-hydroxy-2-(5-...)
Affinity DataIC50:  16nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10553((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[2-(5-acetyl-2-m...)
Affinity DataIC50:  16nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10535((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2R)-2-(5-bromo...)
Affinity DataIC50:  17nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10527((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-bromo-2-me...)
Affinity DataIC50:  18nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10527((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-bromo-2-me...)
Affinity DataIC50:  18nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10653((3S)-5-[(2-CHLORO-6-FLUOROBENZYL)SULFANYL]-3-{[N-(...)
Affinity DataIC50:  24nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50:  27nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50:  27nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM50203365((3S)-3-(2-(5-tert-butyl-3-(2,3-dihydrobenzo[b][1,4...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10549((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[2-(2,5-dimethox...)
Affinity DataIC50:  29nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10537((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2R)-2-hydroxy-...)
Affinity DataIC50:  41nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10548((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(2,5-dimethox...)
Affinity DataIC50:  48nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM50203366((3S)-3-(2-(5-tert-butyl-2-oxo-3-(2-(thiophen-2-yl)...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10548((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(2,5-dimethox...)
Affinity DataIC50:  53nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10669((3S)-5-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}...)
Affinity DataIC50:  53nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10527((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-bromo-2-me...)
Affinity DataIC50:  60nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10555((3S)-5-(benzylsulfanyl)-3-[(2S)-2-{2-hydroxy-2-[2-...)
Affinity DataIC50:  63nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10664((3S)-5-[(cyclohexylmethyl)sulfanyl]-3-[(2S)-2-[1-(...)
Affinity DataIC50:  63nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50203364(CHEMBL248310 | N-((S)-3-(2-(3-(1H-tetrazol-5-ylami...)
Affinity DataIC50:  64.7nMAssay Description:Inhibition of human recombinant caspase 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10663((3S)-5-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}...)
Affinity DataIC50:  73nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10533((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2S)-2-(5-bromo...)
Affinity DataIC50:  80nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10661((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(5-fluoro-1H-in...)
Affinity DataIC50:  83nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10542((3S)-5-(benzylsulfanyl)-3-[(2S)-2-(2-hydroxy-2-phe...)
Affinity DataIC50:  85nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50:  87nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
TargetCaspase-7(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10551((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[2-(5-bromo-2-me...)
Affinity DataIC50:  91nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10535((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2R)-2-(5-bromo...)
Affinity DataIC50:  92nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10670((3S)-5-{[(2-chloro-6-fluorophenyl)methyl]sulfanyl}...)
Affinity DataIC50:  94nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10554((3S)-5-(benzylsulfanyl)-3-[(2S)-2-{1-[2-methoxy-5-...)
Affinity DataIC50:  97nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10556((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[2-hydroxy-2-(5-...)
Affinity DataIC50:  98nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM50203362((3S)-3-(2-(5-tert-butyl-3-(1-carboxy-3-methylbutyl...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant caspase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10538((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2S)-2-hydroxy-...)
Affinity DataIC50:  100nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM10551((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[2-(5-bromo-2-me...)
Affinity DataIC50:  104nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10540((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[(2S)-2-hydroxy-...)
Affinity DataIC50:  118nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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