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Found 950 with Last Name = 'vaisburg' and Initial = 'a'
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369539(US10233152, Example 64)
Affinity DataIC50:  0.900nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369535(US10233152, Example 60)
Affinity DataIC50:  1nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50303276(CHEMBL565807 | N-(4-(2-(1-ethyl-1H-imidazole-4-car...)
Affinity DataIC50:  1nMAssay Description:Inhibition of VEGFR2 assessed as inhibition of ERK phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369495(US10233152, Example 33)
Affinity DataIC50: <1nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369532(US10233152, Example 57)
Affinity DataIC50:  2nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50114813(8-(4'-Bromo-biphenyl-4-yl)-8-oxo-octanoic acid hyd...)
Affinity DataIC50:  2nMAssay Description:Inhibition against partially purified human histone deacetylase 1 (HDAC-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM93149(2-oxoimidazolidine-1-carboxamide, 16)
Affinity DataIC50:  2nMAssay Description:Inhibition assay using kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369621(US10233152, Example 128)
Affinity DataIC50:  2nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369533(US10233152, Example 58)
Affinity DataIC50:  3nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369478(N,N-Dimethyl-2-(4-(2-(4-(((1R,2S)-2-phenylcyclopro...)
Affinity DataIC50:  3nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369650(US10233152, Example 157)
Affinity DataIC50:  3nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369484(US10233152, Example 24)
Affinity DataIC50:  3nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM93147(2-oxoimidazolidine-1-carboxamide, 14)
Affinity DataIC50:  3nMAssay Description:Inhibition assay using kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369512(US10233152, Example 50)
Affinity DataIC50:  3nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248054(CHEMBL508395 | N-(3-fluoro-4-(2-(4-((methyl(2-(4-m...)
Affinity DataIC50:  3nMAssay Description:Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50248089(CHEMBL517469 | N-(4-(2-(1-ethyl-1H-imidazol-4-yl)t...)
Affinity DataIC50:  3nMAssay Description:Inhibition of GST-fused recombinant VGFR2 (unknown origin) catalytic domain expressed in baculovirus-infected Sf9 cells after 10 mins by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369496(US10233152, Example 34)
Affinity DataIC50:  3nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369530(US10233152, Example 55)
Affinity DataIC50:  4nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50114835((E)-8-(biphenyl-4-yl)-N-hydroxy-8-(hydroxyimino)oc...)
Affinity DataIC50:  4nMAssay Description:Inhibition against partially purified human histone deacetylase 1 (HDAC-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369551(US10233152, Example 74)
Affinity DataIC50:  4nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369574(US10233152, Example 89)
Affinity DataIC50:  4nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369576(US10233152, Example 91)
Affinity DataIC50:  4nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369476(N-(Methylsulfonyl)-2-(4-(2-(4-(((1R,2S)-2-phenylcy...)
Affinity DataIC50:  4nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369483(US10233152, Example 23)
Affinity DataIC50:  4nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369491(US10233152, Example 29)
Affinity DataIC50:  4nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM270491(US10059668, Example 55)
Affinity DataIC50:  4nMpH: 7.5 T: 2°CAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50303262(CHEMBL566010 | N1-(3-fluoro-4-(2-(pyrrolidine-1-ca...)
Affinity DataIC50:  4nMAssay Description:Inhibition of GST-fused recombinant VEGFR2 expressed in baculovirus infected Sf9 cells after 10 mins by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50303276(CHEMBL565807 | N-(4-(2-(1-ethyl-1H-imidazole-4-car...)
Affinity DataIC50:  4nMAssay Description:Inhibition of TPR-met autophosphorylation expressed in HEK293T cells after 150 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM93145(2-oxoimidazolidine-1-carboxamide, 5)
Affinity DataIC50:  4nMAssay Description:Inhibition assay using kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM93150(2-oxoimidazolidine-1-carboxamide, 17)
Affinity DataIC50:  4nMAssay Description:Inhibition assay using kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369541(US10233152, Example 66)
Affinity DataIC50:  4nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50114811(8-Oxo-8-[4-(4-phenyl-piperazin-1-yl)-phenyl]-octan...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition against partially purified human histone deacetylase 1 (HDAC-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369531(US10233152, Example 56)
Affinity DataIC50:  5nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50114816(8-(biphenyl-4-yl)-N-hydroxy-8-oxooctanamide | 8-Bi...)
Affinity DataIC50:  5nMAssay Description:Inhibition against partially purified human histone deacetylase 1 (HDAC-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369580(US10233152, Example 95)
Affinity DataIC50:  5nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369593(US10233152, Example 104)
Affinity DataIC50:  5nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369472(1-[2-(4-bromophenoxy)ethyl]-N-[(1R,2S)-2-phenylcyc...)
Affinity DataIC50:  5nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369480(1-[2-(4-morpholinophenoxy)ethyl]-N—[(R, 2S)-2...)
Affinity DataIC50:  5nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369643(US10233152, Example 150)
Affinity DataIC50:  5nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369482(US10233152, Example 22)
Affinity DataIC50:  5nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369481(US10233152, Example 21)
Affinity DataIC50:  5nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM270481(US10059668, Example 44)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50303266(CHEMBL565990 | N1-(4-(2-(1-ethyl-1H-imidazole-4-ca...)
Affinity DataIC50:  5nMAssay Description:Inhibition of GST-fused recombinant VEGFR2 expressed in baculovirus infected Sf9 cells after 10 mins by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50303272(CHEMBL567475 | N1-(4-(2-(1-ethyl-1H-imidazole-4-ca...)
Affinity DataIC50:  5nMAssay Description:Inhibition of GST-fused recombinant VEGFR2 expressed in baculovirus infected Sf9 cells after 10 mins by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM93148(2-oxoimidazolidine-1-carboxamide, 15)
Affinity DataIC50:  5nMAssay Description:Inhibition assay using kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  5nMAssay Description:Inhibition against partially purified human histone deacetylase 1 (HDAC-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50114814(8-Naphthalen-2-yl-8-oxo-octanoic acid hydroxyamide...)
Affinity DataIC50:  5nMAssay Description:Inhibition against partially purified human histone deacetylase 1 (HDAC-1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369550(US10233152, Example 73)
Affinity DataIC50:  5nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369545(US10233152, Example 68)
Affinity DataIC50:  6nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM369570(US10233152, Example 85)
Affinity DataIC50:  6nMAssay Description:Briefly, compounds of the present invention were solubilized in DMSO and a series of 10, three-fold serial dilutions were made for each compound in 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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