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Found 199 with Last Name = 'valentine' and Initial = 'a'
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85530(Nor-d-fenfluramine | Nor-dexfenfluramine | Norfenf...)
Affinity DataKi:  27nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85530(Nor-d-fenfluramine | Nor-dexfenfluramine | Norfenf...)
Affinity DataKi:  56nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85598(l-norfenfluramine)
Affinity DataKi:  65nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85598(l-norfenfluramine)
Affinity DataKi:  99nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85530(Nor-d-fenfluramine | Nor-dexfenfluramine | Norfenf...)
Affinity DataKi:  187nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85598(l-norfenfluramine)
Affinity DataKi:  267nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85597(CAS_37577-24-5 | NSC_65801 | l-Fenfluramine)
Affinity DataKi:  680nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85597(CAS_37577-24-5 | NSC_65801 | l-Fenfluramine)
Affinity DataKi:  1.43E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85597(CAS_37577-24-5 | NSC_65801 | l-Fenfluramine)
Affinity DataKi:  1.62E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85596(CAS_3239-45-0 | NSC_65801 | d-Fenfluramine)
Affinity DataKi:  2.08E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85596(CAS_3239-45-0 | NSC_65801 | d-Fenfluramine)
Affinity DataKi:  3.92E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325177(5-methyl-8-(1H-pyrrol-2-yl)-[1,2,4]triazolo[4,3-a]...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7667(4-[(4-{6-bromoimidazo[1,2-a]pyridin-3-yl}pyrimidin...)
Affinity DataIC50: <3nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7668(4-[(4-{6-cyanoimidazo[1,2-a]pyridin-3-yl}pyrimidin...)
Affinity DataIC50: <3nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7671(4-[(4-{imidazo[1,2-a]pyridazin-3-yl}pyrimidin-2-yl...)
Affinity DataIC50: <3nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7675(Imidazo[1,2-b]pyridazine deriv. 2e | N-[3-(dimethy...)
Affinity DataIC50: <3nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7669(4-({4-[6-(ethylsulfanyl)imidazo[1,2-a]pyridin-3-yl...)
Affinity DataIC50: <3nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7679(Imidazo[1,2-b]pyridazine deriv. 4b | N-(2-methoxye...)
Affinity DataIC50:  3nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7672(4-[(4-{imidazo[1,2-a]pyridazin-3-yl}pyrimidin-2-yl...)
Affinity DataIC50: <3nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7673(4-[(4-{imidazo[1,2-a]pyridazin-3-yl}pyrimidin-2-yl...)
Affinity DataIC50: <3nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325145(5-methyl-8-(1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a...)
Affinity DataIC50:  4nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325161(5-methyl-8-(4-(piperazin-1-ylmethyl)phenyl)-[1,2,4...)
Affinity DataIC50:  6nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325162(5-methyl-8-(3-(piperazin-1-ylmethyl)phenyl)-[1,2,4...)
Affinity DataIC50:  7nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605601(CHEMBL5184138)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7674(CHEMBL484571 | Imidazo[1,2-b]pyridazine deriv. 2d ...)
Affinity DataIC50:  8nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605597(CHEMBL5204161)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325163(5-methyl-8-(4-((4-methylpiperazin-1-yl)methyl)phen...)
Affinity DataIC50:  9nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605598(CHEMBL5188193)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325164(5-methyl-8-(4-(morpholinomethyl)phenyl)-[1,2,4]tri...)
Affinity DataIC50:  9nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50280450(18-hydroxy-3-methoxy-2-methyl-4-methylamino-(2R,3S...)
Affinity DataIC50:  10nMAssay Description:Inhibition of CHK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50280450(18-hydroxy-3-methoxy-2-methyl-4-methylamino-(2R,3S...)
Affinity DataIC50:  10nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325169(8-(4-(hydroxymethyl)phenyl)-5-methyl-[1,2,4]triazo...)
Affinity DataIC50:  10nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325150(8-(4-(2-(diethylamino)ethoxy)phenyl)-5-methyl-[1,2...)
Affinity DataIC50:  10nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325147(8-(furan-2-yl)-5-methyl-[1,2,4]triazolo[4,3-a]quin...)
Affinity DataIC50:  10nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605555(CHEMBL5173250)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605593(CHEMBL5179642)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325171(5-METHYL-8-PYRIDIN-4-YL[1,2,4]TRIAZOLO[4,3-A]QUINO...)
Affinity DataIC50:  14nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM7670(Imidazo[1,2-a]pyridine deriv. 4g | N-(2-methoxyeth...)
Affinity DataIC50:  16nMpH: 7.0 T: 2°CAssay Description:The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM210802(US10463663, Example 40 | US11129828, Example 40 | ...)
Affinity DataIC50:  17nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325175(5-methyl-8-(thiophen-2-yl)-[1,2,4]triazolo[4,3-a]q...)
Affinity DataIC50:  20nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605594(CHEMBL5186374)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605599(CHEMBL5178413)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325158(CHEMBL1223317 | N-ethyl-4-(5-methyl-1-oxo-1,2-dihy...)
Affinity DataIC50:  20nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605592(CHEMBL5179643)
Affinity DataIC50:  21nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605595(CHEMBL5174518)
Affinity DataIC50:  25nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605589(CHEMBL5196542)
Affinity DataIC50:  25nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325144(5-methyl-8-(1H-pyrrol-3-yl)-[1,2,4]triazolo[4,3-a]...)
Affinity DataIC50:  26nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Schr£Dinger

Curated by ChEMBL
LigandPNGBDBM50605552(CHEMBL5204839)
Affinity DataIC50:  28nMAssay Description:Inhibition of recombinant full length human DAO preincubated with compound for 20 mins measured after 4 hrs by Amplex red and horseradish peroxidase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325151(5-methyl-8-(4-(2-morpholinoethoxy)phenyl)-[1,2,4]t...)
Affinity DataIC50:  30nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50325155(4-(5-methyl-1-oxo-1,2-dihydro-[1,2,4]triazolo[4,3-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of His6-CHK1 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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