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Found 145 with Last Name = 'valentine' and Initial = 'h'
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23334(3-(pyridin-3-yl)propyl (2S)-1-(3,3-dimethyl-2-oxop...)
Affinity DataKi:  0.0100nMAssay Description:Ability to inhibit peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
TargetB2 bradykinin receptor(Homo sapiens (Human))
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50052513(8-Methyl-3-(2-oxo-propyl)-1-phenethyl-1,3,8-triaza...)
Affinity DataKi:  0.150nMAssay Description:Affinity to human Bradykinin receptor B2 in CHO cell membranes determined by displacement of [3H]-NPC 17731More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50385393(CHEMBL2036415)
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]A585539 from alpha7 nAChR from rat brain membrane with no cerebellum/cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50052512(1-Cyclohexyl-8-methyl-3-(2-oxo-propyl)-1,3,8-triaz...)
Affinity DataKi:  0.570nMAssay Description:Affinity to human Bradykinin receptor B2 in CHO cell membranes determined by displacement of [3H]-NPC 17731More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
The Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50385392(CHEMBL2036416)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]A585539 from alpha7 nAChR from rat brain membrane with no cerebellum/cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
Johns Hopkins Medical Institutions

Curated by ChEMBL
LigandPNGBDBM50326618(CHEMBL1254015 | [11C]-3-(2-methoxyethyl)-4,5-dimet...)
Affinity DataKi:  0.700nMAssay Description:Agonist activity at CB2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068597(1-[2-Oxo-2-(3,4,5-trimethoxy-phenyl)-acetyl]-piper...)
Affinity DataKi:  1nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113103(1-(3,3-Dimethyl-2-oxo-pentanoyl)-pyrrolidine-2-car...)
Affinity DataKi:  1nMAssay Description:Ability to inhibit peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068564(1-(3,3-Dimethyl-2-oxo-butyryl)-piperidine-2-carbox...)
Affinity DataKi:  2nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068573(1-(2-Oxo-2-phenyl-acetyl)-piperidine-2-carboxylic ...)
Affinity DataKi:  3nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068582(1-(3,3-Dimethyl-2-oxo-butyryl)-piperidine-2-carbox...)
Affinity DataKi:  5nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116632(1-(3,3-Dimethyl-2-oxo-pentanoyl)-pyrrolidine-2-car...)
Affinity DataKi:  6nMAssay Description:Inhibitory activity against FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50052511(8-Methyl-3-(2-oxo-propyl)-1-p-tolyl-1,3,8-triaza-s...)
Affinity DataKi:  6.30nMAssay Description:Affinity to human Bradykinin receptor B2 in CHO cell membranes determined by displacement of [3H]-NPC 17731More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetB2 bradykinin receptor(Homo sapiens (Human))
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50052509(1-Cyclohexylmethyl-8-methyl-3-(2-oxo-propyl)-1,3,8...)
Affinity DataKi:  6.80nMAssay Description:Affinity to human Bradykinin receptor B2 in CHO cell membranes determined by displacement of [3H]-NPC 17731More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116633(1-(3,3-Dimethyl-2-oxo-pentanoyl)-pyrrolidine-2-car...)
Affinity DataKi:  7nMAssay Description:Inhibitory activity against FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Bos taurus (bovine))
Guilford Pharmaceuticals

LigandPNGBDBM23334(3-(pyridin-3-yl)propyl (2S)-1-(3,3-dimethyl-2-oxop...)
Affinity DataKi:  7.5nM ΔG°:  -42.5kJ/molepH: 8.0 T: 2°CAssay Description:PPIase(Rotamase) activity of FKBP12 was assayed using the peptide N-succinyl Ala-Leu-Pro-Phe p-nitroanilide as substrate. It is based on the observat...More data for this Ligand-Target Pair
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23334(3-(pyridin-3-yl)propyl (2S)-1-(3,3-dimethyl-2-oxop...)
Affinity DataKi:  7.5nMAssay Description:Inhibitory activity against FK506 binding protein 12More data for this Ligand-Target Pair
TargetB2 bradykinin receptor(Homo sapiens (Human))
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50052514(8-Methyl-3-(2-oxo-propyl)-1-phenyl-1,3,8-triaza-sp...)
Affinity DataKi:  7.70nMAssay Description:Affinity to human Bradykinin receptor B2 in CHO cell membranes determined by displacement of [3H]-NPC 17731More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068610(1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carb...)
Affinity DataKi:  8.30nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116636(1-(3,3-Dimethyl-2-oxo-pentanoyl)-pyrrolidine-2-car...)
Affinity DataKi:  8.70nMAssay Description:Inhibitory activity against FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116630(1-(3,3-Dimethyl-2-oxo-pentanoyl)-pyrrolidine-2-car...)
Affinity DataKi:  8.90nMAssay Description:Inhibitory activity against FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116631(1-(3,3-Dimethyl-2-oxo-pentanoyl)-pyrrolidine-2-car...)
Affinity DataKi:  11nMAssay Description:Inhibitory activity against FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113058(1-(Adamantan-1-ylcarbamoyl)-piperidine-2-carboxyli...)
Affinity DataKi:  12nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116635(1-(3,3-Dimethyl-2-oxo-pentanoyl)-pyrrolidine-2-car...)
Affinity DataKi:  12.2nMAssay Description:Inhibitory activity against FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50289698(1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carb...)
Affinity DataKi:  15nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068594(1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carb...)
Affinity DataKi:  20nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113095((S)-1-Phenylmethanesulfonyl-pyrrolidine-2-carboxyl...)
Affinity DataKi:  22nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068591(1-(3,3-Dimethyl-2-oxo-butyryl)-piperidine-2-carbox...)
Affinity DataKi:  24nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068589(1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carb...)
Affinity DataKi:  25nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetB2 bradykinin receptor(Homo sapiens (Human))
Scios Nova

Curated by ChEMBL
LigandPNGBDBM50052510(8-Methyl-3-(2-oxo-propyl)-1-propyl-1,3,8-triaza-sp...)
Affinity DataKi:  27nMAssay Description:Affinity to human Bradykinin receptor B2 in CHO cell membranes determined by displacement of [3H]-NPC 17731More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Bos taurus (bovine))
Guilford Pharmaceuticals

LigandPNGBDBM23319(3,3-dimethyl-1-[(2S)-2-(5-phenylpentanoyl)pyrrolid...)
Affinity DataKi:  30nM ΔG°:  -39.3kJ/molepH: 8.0 T: 2°CAssay Description:PPIase(Rotamase) activity of FKBP12 was assayed using the peptide N-succinyl Ala-Leu-Pro-Phe p-nitroanilide as substrate. It is based on the observat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068572(1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carb...)
Affinity DataKi:  30nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113063(1-(Adamantan-1-ylcarbamoyl)-piperidine-2-carboxyli...)
Affinity DataKi:  32nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113077(1-Phenylmethanesulfonyl-piperidine-2-carboxylic ac...)
Affinity DataKi:  47nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068596(1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carb...)
Affinity DataKi:  60nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50116637(1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carb...)
Affinity DataKi:  86nMAssay Description:Inhibitory activity against FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113070((S)-1-Cyclohexylthiocarbamoyl-pyrrolidine-2-carbox...)
Affinity DataKi:  86nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113056(1-Phenylmethanesulfonyl-piperidine-2-carboxylic ac...)
Affinity DataKi:  92nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113113((S)-1-Phenylmethanesulfonyl-piperidine-2-carboxyli...)
Affinity DataKi:  110nMAssay Description:Ability to inhibit peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113071(1-Phenylmethanesulfonyl-piperidine-2-carboxylic ac...)
Affinity DataKi:  120nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Bos taurus (bovine))
Guilford Pharmaceuticals

LigandPNGBDBM23322(3,3-dimethyl-1-[(2S)-2-{5-[2,3,5,6-tetrafluoro-4-(...)
Affinity DataKi:  130nM ΔG°:  -36.0kJ/molepH: 8.0 T: 2°CAssay Description:PPIase(Rotamase) activity of FKBP12 was assayed using the peptide N-succinyl Ala-Leu-Pro-Phe p-nitroanilide as substrate. It is based on the observat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Bos taurus (bovine))
Guilford Pharmaceuticals

LigandPNGBDBM23323(3,3-dimethyl-1-[(2S)-2-(4-phenylbutanoyl)pyrrolidi...)
Affinity DataKi:  180nM ΔG°:  -35.3kJ/molepH: 8.0 T: 2°CAssay Description:PPIase(Rotamase) activity of FKBP12 was assayed using the peptide N-succinyl Ala-Leu-Pro-Phe p-nitroanilide as substrate. It is based on the observat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113092(1-Benzenesulfonyl-piperidine-2-carboxylic acid 3-(...)
Affinity DataKi:  180nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Bos taurus (bovine))
Guilford Pharmaceuticals

LigandPNGBDBM23325(3,3-dimethyl-1-[(2S)-2-[5-(pyridin-3-yl)pentanoyl]...)
Affinity DataKi:  210nM ΔG°:  -34.9kJ/molepH: 8.0 T: 2°CAssay Description:PPIase(Rotamase) activity of FKBP12 was assayed using the peptide N-succinyl Ala-Leu-Pro-Phe p-nitroanilide as substrate. It is based on the observat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113091(1-(Toluene-4-sulfonyl)-piperidine-2-carboxylic aci...)
Affinity DataKi:  220nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Bos taurus (bovine))
Guilford Pharmaceuticals

LigandPNGBDBM23324(1-[(2S)-2-[5-(4-hydroxyphenyl)pentanoyl]pyrrolidin...)
Affinity DataKi:  240nM ΔG°:  -34.6kJ/molepH: 8.0 T: 2°CAssay Description:PPIase(Rotamase) activity of FKBP12 was assayed using the peptide N-succinyl Ala-Leu-Pro-Phe p-nitroanilide as substrate. It is based on the observat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidylprolyl isomerase(Gallus gallus)
TBA

Curated by ChEMBL
LigandPNGBDBM50068555(1-(3,3-Dimethyl-2-oxo-pentanoyl)-piperidine-2-carb...)
Affinity DataKi:  250nMAssay Description:Inhibition of binding to FKBP12 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Homo sapiens (Human))
Guilford Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50113072(1-Benzenesulfonyl-piperidine-2-carboxylic acid 3-(...)
Affinity DataKi:  260nMAssay Description:Inhibition of peptidyl-prolyl isomerase (PPIase, or rotamase) activity of FK506 binding protein 12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Bos taurus (bovine))
Guilford Pharmaceuticals

LigandPNGBDBM23333(3,3-dimethyl-1-[(2S)-2-(6-phenylhexanoyl)piperidin...)
Affinity DataKi:  290nM ΔG°:  -34.2kJ/molepH: 8.0 T: 2°CAssay Description:PPIase(Rotamase) activity of FKBP12 was assayed using the peptide N-succinyl Ala-Leu-Pro-Phe p-nitroanilide as substrate. It is based on the observat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeptidyl-prolyl cis-trans isomerase FKBP1A(Bos taurus (bovine))
Guilford Pharmaceuticals

LigandPNGBDBM23320(1-cyclohexyl-2-[(2S)-2-(5-phenylpentanoyl)pyrrolid...)
Affinity DataKi:  310nM ΔG°:  -34.0kJ/molepH: 8.0 T: 2°CAssay Description:PPIase(Rotamase) activity of FKBP12 was assayed using the peptide N-succinyl Ala-Leu-Pro-Phe p-nitroanilide as substrate. It is based on the observat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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