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Found 46 with Last Name = 'vandromme' and Initial = 'l'
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Institut Curie

LigandPNGBDBM7576(1-(6-{[(4-chlorophenyl)methyl]amino}-9-(propan-2-y...)
Affinity DataIC50:  60nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Institut Curie

LigandPNGBDBM7573(1-(6-{[(4-methoxyphenyl)methyl]amino}-9-(propan-2-...)
Affinity DataIC50:  230nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50197305(CHEMBL225096 | N-[6-(4-chloro-benzylamino)-9-isopr...)
Affinity DataIC50:  900nMAssay Description:Inhibition of recombinant mammalian CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Institut Curie

LigandPNGBDBM10651(2-purine deriv. 17 | 4-(6-{[(4-methoxyphenyl)methy...)
Affinity DataIC50:  1.30E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50197317(CHEMBL225043 | N-[9-isopropyl-6-(4-methoxy-benzyla...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of recombinant mammalian CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Institut Curie

LigandPNGBDBM10643(2-arylpurine deriv. 8 | 4-{6-[(2-methoxyethyl)amin...)
Affinity DataIC50:  1.40E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Institut Curie

LigandPNGBDBM10643(2-arylpurine deriv. 8 | 4-{6-[(2-methoxyethyl)amin...)
Affinity DataIC50:  1.40E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Institut Curie

LigandPNGBDBM10651(2-purine deriv. 17 | 4-(6-{[(4-methoxyphenyl)methy...)
Affinity DataIC50:  1.50E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50197316(CHEMBL224257 | N-[9-isopropyl-6-(4-methoxy-benzyla...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of recombinant mammalian CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50197312(CHEMBL425121 | N-[6-(4-chloro-benzylamino)-9-isopr...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of recombinant mammalian CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50197319(CHEMBL225002 | N-[9-isopropyl-6-(4-methoxy-benzyla...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of recombinant mammalian CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Institut Curie

LigandPNGBDBM10646(2-arylpurine deriv. 11 | 4-{6-[(2-methoxyethyl)ami...)
Affinity DataIC50:  1.80E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50197308(6-(4-chloro-benzylamino)-9-isopropyl-9H-purine-2-c...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of recombinant mammalian CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50197307(9-isopropyl-6-(4-methoxy-benzylamino)-9H-purine-2-...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of recombinant mammalian CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50197322(CHEMBL225645 | N-[6-(4-chlorobenzylamino)-9-isopro...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of recombinant mammalian CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Institut Curie

LigandPNGBDBM10650(2-purine deriv. 15 | 5-{6-[(2-methoxyethyl)amino]-...)
Affinity DataIC50:  2.20E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Institut Curie

LigandPNGBDBM10650(2-purine deriv. 15 | 5-{6-[(2-methoxyethyl)amino]-...)
Affinity DataIC50:  2.30E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Institut Curie

LigandPNGBDBM10645(2-arylpurine deriv. 10 | N-(4-{6-[(2-methoxyethyl)...)
Affinity DataIC50:  2.30E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50197318(9-isopropyl-6-(4-methoxy-benzylamino)-9H-purine-2-...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of recombinant mammalian CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Institut Curie

LigandPNGBDBM10644(1-(4-{6-[(2-methoxyethyl)amino]-9-(propan-2-yl)-9H...)
Affinity DataIC50:  2.50E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Institut Curie

LigandPNGBDBM10644(1-(4-{6-[(2-methoxyethyl)amino]-9-(propan-2-yl)-9H...)
Affinity DataIC50:  2.80E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Institut Curie

LigandPNGBDBM10645(2-arylpurine deriv. 10 | N-(4-{6-[(2-methoxyethyl)...)
Affinity DataIC50:  3.00E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Institut Curie

LigandPNGBDBM10646(2-arylpurine deriv. 11 | 4-{6-[(2-methoxyethyl)ami...)
Affinity DataIC50:  3.10E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Institut Curie

LigandPNGBDBM10649(1-(5-{6-[(2-methoxyethyl)amino]-9-(propan-2-yl)-9H...)
Affinity DataIC50:  3.20E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50197321(CHEMBL225055 | N-[9-isopropyl-6-(4-methoxy-benzyla...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of recombinant mammalian CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Institut Curie

LigandPNGBDBM10647(2-arylpurine deriv. 12 | N-(2-cyanoethyl)-4-{6-[(2...)
Affinity DataIC50:  3.40E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50197310(CHEMBL389447 | N-[9-isopropyl-6-(4-methoxy-benzyla...)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of recombinant mammalian CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Institut Curie

LigandPNGBDBM10648(2-arylpurine deriv. 13 | methyl N-(4-{6-[(2-methox...)
Affinity DataIC50:  4.00E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Institut Curie

LigandPNGBDBM10647(2-arylpurine deriv. 12 | N-(2-cyanoethyl)-4-{6-[(2...)
Affinity DataIC50:  4.20E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Institut Curie

LigandPNGBDBM10648(2-arylpurine deriv. 13 | methyl N-(4-{6-[(2-methox...)
Affinity DataIC50:  4.40E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Institut Curie

LigandPNGBDBM10649(1-(5-{6-[(2-methoxyethyl)amino]-9-(propan-2-yl)-9H...)
Affinity DataIC50:  4.90E+3nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50197314(CHEMBL224694 | N-[9-isopropyl-6-(methoxy-ethylamin...)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of recombinant mammalian CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50197311(CHEMBL224386 | N-[9-isopropyl-6-(methoxy-ethylamin...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of recombinant mammalian CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50197315(CHEMBL225056 | N-[9-isopropyl-6-(methoxy-ethylamin...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of recombinant mammalian CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50197309(9-isopropyl-6-(2-methoxy-ethylamino)-9H-purine-2-c...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of recombinant mammalian CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50197306(9-isopropyl-6-(2-methoxy-ethylamino)-9H-purine-2-c...)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of recombinant mammalian CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM50197320(CHEMBL224927 | N-[6-(4-chloro-benzylamino)-9-isopr...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of recombinant mammalian CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Institut Curie

LigandPNGBDBM10646(2-arylpurine deriv. 11 | 4-{6-[(2-methoxyethyl)ami...)
Affinity DataIC50: >1.00E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Institut Curie

LigandPNGBDBM10643(2-arylpurine deriv. 8 | 4-{6-[(2-methoxyethyl)amin...)
Affinity DataIC50: >1.00E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Institut Curie

LigandPNGBDBM10644(1-(4-{6-[(2-methoxyethyl)amino]-9-(propan-2-yl)-9H...)
Affinity DataIC50: >1.00E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Institut Curie

LigandPNGBDBM10651(2-purine deriv. 17 | 4-(6-{[(4-methoxyphenyl)methy...)
Affinity DataIC50: >1.00E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Institut Curie

LigandPNGBDBM10650(2-purine deriv. 15 | 5-{6-[(2-methoxyethyl)amino]-...)
Affinity DataIC50: >1.00E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Institut Curie

LigandPNGBDBM10649(1-(5-{6-[(2-methoxyethyl)amino]-9-(propan-2-yl)-9H...)
Affinity DataIC50: >1.00E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Institut Curie

LigandPNGBDBM10645(2-arylpurine deriv. 10 | N-(4-{6-[(2-methoxyethyl)...)
Affinity DataIC50: >1.00E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Institut Curie

LigandPNGBDBM10647(2-arylpurine deriv. 12 | N-(2-cyanoethyl)-4-{6-[(2...)
Affinity DataIC50: >1.00E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Institut Curie

LigandPNGBDBM10648(2-arylpurine deriv. 13 | methyl N-(4-{6-[(2-methox...)
Affinity DataIC50: >1.00E+5nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed