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Found 80 with Last Name = 'varga' and Initial = 'sl'
TargetCarbonic anhydrase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM10882(6-ethoxy-1,3-benzothiazole-2-sulfonamide | CHEMBL1...)
Affinity DataKi:  0.490nMAssay Description:In vitro binding to human erythrocyte carbonic anhydrase was determined by fluorescence competition assay employing the fluorescent CA inhibitor dans...More data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50024220(7-Oxo-6,7-dihydro-5H-thieno[3,2-b]thiopyran-2-sulf...)
Affinity DataKi:  1.20nMAssay Description:In vitro inhibition against purified human erythrocyte carbonic anhydrase II was determined (acetozolamide used as control.)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50024224(7,7-Dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3...)
Affinity DataKi:  3.30nMAssay Description:In vitro binding to human erythrocyte carbonic anhydrase was determined by fluorescence competition assay employing the fluorescent CA inhibitor dans...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50024221(4-Oxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulf...)
Affinity DataKi:  3.60nMAssay Description:In vitro inhibition against purified human erythrocyte carbonic anhydrase II was determined (acetozolamide used as control.)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50452418(CHEMBL2092886)
Affinity DataKi:  6.70nMAssay Description:In vitro inhibition against purified human erythrocyte carbonic anhydrase II was determined (acetozolamide used as control.)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50024222(5-Hydroxy-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-...)
Affinity DataKi:  7.10nMAssay Description:In vitro inhibition against purified human erythrocyte carbonic anhydrase II was determined (acetozolamide used as control.)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50017727((R) 4-Hydroxy-7,7-dioxo-4,5,6,7-tetrahydro-7lambda...)
Affinity DataKi:  8.40nMAssay Description:In vitro binding to human erythrocyte Carbonic anhydrase II was determined by fluorescence competition assay employing the fluorescent CA inhibitor d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50024219(4,4,7-Trioxo-4,5,6,7-tetrahydro-4lambda*6*-thieno[...)
Affinity DataKi:  14nMAssay Description:In vitro inhibition against purified human erythrocyte carbonic anhydrase II was determined (acetozolamide used as control.)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50024227(7-Hydroxy-6,7-dihydro-5H-thieno[3,2-b]thiopyran-2-...)
Affinity DataKi:  14nMAssay Description:In vitro inhibition against purified human erythrocyte carbonic anhydrase II was determined (acetozolamide used as control.)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50367483(CHEMBL1788205)
Affinity DataKi:  15nMAssay Description:In vitro binding to human erythrocyte carbonic anhydrase was determined by fluorescence competition assay employing the fluorescent CA inhibitor dans...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50024223(6-Hydroxy-4,4-dioxo-4,5,6,7-tetrahydro-4lambda*6*-...)
Affinity DataKi:  18nMAssay Description:In vitro binding to human erythrocyte carbonic anhydrase was determined by fluorescence competition assay employing the fluorescent CA inhibitor dans...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50024225(4-Hydroxy-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-...)
Affinity DataKi:  28nMAssay Description:In vitro binding to human erythrocyte Carbonic anhydrase II was determined by fluorescence competition assay employing the fluorescent CA inhibitor d...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50024218(7-Hydroxy-4,4-dioxo-4,5,6,7-tetrahydro-4lambda*6*-...)
Affinity DataKi:  31nMAssay Description:In vitro inhibition against purified human erythrocyte carbonic anhydrase II was determined (acetozolamide used as control.)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50024226(4-Hydroxy-7-oxo-4,5,6,7-tetrahydro-7lambda*4*-thie...)
Affinity DataKi:  104nMAssay Description:In vitro inhibition against purified human erythrocyte carbonic anhydrase II was determined (acetozolamide used as control.)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50024228(7-Hydroxy-4-oxo-4,5,6,7-tetrahydro-4lambda*4*-thie...)
Affinity DataKi:  309nMAssay Description:In vitro inhibition against purified human erythrocyte carbonic anhydrase II was determined (acetozolamide used as control.)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134778((S)-3-(6-Methoxy-pyridin-3-yl)-3-{2-oxo-3-[3-(5,6,...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134777((S)-3-(2,3-Dihydro-benzofuran-6-yl)-3-{2-oxo-3-[3-...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134780((S)-3-{2-Oxo-3-[3-(5,6,7,8-tetrahydro-[1,8]naphthy...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134776((S)-3-(3-Fluoro-4-methoxy-phenyl)-3-{2-oxo-3-[3-(5...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134779((S)-3-{3-[3-(7-Hydroxy-5,6,7,8-tetrahydro-[1,8]nap...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134775((S)-3-(6-Methoxy-pyridin-3-yl)-3-{2-oxo-3-[3-oxo-3...)
Affinity DataIC50:  3nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077960(4-[5-(3,4-Dichloro-phenyl)-2-phenyl-3H-imidazol-4-...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077961(3-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-pheno...)
Affinity DataIC50:  23nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077957(4-[2-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-...)
Affinity DataIC50:  29nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077974(4-(4-(4-chlorophenyl)-2-phenyl-1H-imidazol-5-yl)py...)
Affinity DataIC50:  56nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077958(4-[5-(4-Fluoro-phenyl)-2-piperidin-4-yl-3H-imidazo...)
Affinity DataIC50:  80nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077964(4-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-benzo...)
Affinity DataIC50:  86nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50237712(4-(4-(3-chlorophenyl)-2-phenyl-1H-imidazol-5-yl)py...)
Affinity DataIC50:  90nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077951(CHEMBL68572 | [4-(2,5-Diphenyl-3H-imidazol-4-yl)-p...)
Affinity DataIC50:  98nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077979(4-[5-(4-Fluoro-phenyl)-2-piperidin-3-yl-3H-imidazo...)
Affinity DataIC50:  110nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077963(4-(2,5-Diphenyl-3H-imidazol-4-yl)-pyridine | CHEMB...)
Affinity DataIC50:  130nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077957(4-[2-Cyclohexyl-5-(4-fluoro-phenyl)-3H-imidazol-4-...)
Affinity DataIC50:  135nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077979(4-[5-(4-Fluoro-phenyl)-2-piperidin-3-yl-3H-imidazo...)
Affinity DataIC50:  140nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50134781((S)-3-(6-Methoxy-pyridin-3-yl)-3-{2-oxo-3-[3-(7-ox...)
Affinity DataIC50:  141nMAssay Description:Inhibition of alphaV-beta3 integrin bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077977(4-(2,4-diphenyl-1H-imidazol-5-yl)-N-methylpyrimidi...)
Affinity DataIC50:  175nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077962(4-(2,5-Diphenyl-3H-imidazol-4-yl)-pyrimidin-2-ylam...)
Affinity DataIC50:  180nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50053410(4-(4-Fluorophenyl)-5-(pyridin-4-yl)-1H-imidazole |...)
Affinity DataIC50:  195nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077958(4-[5-(4-Fluoro-phenyl)-2-piperidin-4-yl-3H-imidazo...)
Affinity DataIC50:  210nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077967(4-(4-(3-methoxyphenyl)-2-phenyl-1H-imidazol-5-yl)p...)
Affinity DataIC50:  210nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Affinity DataIC50:  290nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077969(((R)-1-Phenyl-ethyl)-{4-[2-piperidin-4-yl-5-(3-tri...)
Affinity DataIC50:  295nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077953(4-(1-methyl-2-(piperidin-4-yl)-4-(3-(trifluorometh...)
Affinity DataIC50:  300nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077959(4-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-benzo...)
Affinity DataIC50:  320nMAssay Description:Inhibition of human c-Raf kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM13336(4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...)
Affinity DataIC50:  330nMAssay Description:Inhibition of human c-Raf kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077963(4-(2,5-Diphenyl-3H-imidazol-4-yl)-pyridine | CHEMB...)
Affinity DataIC50:  380nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077976(4-(2-Phenyl-5-pyridin-4-yl-1H-imidazol-4-yl)-pheno...)
Affinity DataIC50:  390nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077952(4-[5-(4-Cyclohexyl-phenyl)-2-phenyl-3H-imidazol-4-...)
Affinity DataIC50:  570nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50237711(4-(4-(2-chlorophenyl)-2-phenyl-1H-imidazol-5-yl)py...)
Affinity DataIC50:  610nMAssay Description:Inhibitory activity against recombinant human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15240(4-[1-methyl-2-(piperidin-4-yl)-4-[3-(trifluorometh...)
Affinity DataIC50:  675nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077970((4-Methoxy-benzyl)-{4-[2-piperidin-4-yl-5-(3-trifl...)
Affinity DataIC50:  735nMAssay Description:Inhibition of c-Jun N-terminal kinase 2-alpha 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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