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Found 144 with Last Name = 'vega' and Initial = 'mj'
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113468(CHEMBL3603915 | US10246432, Example 15 | US1058411...)
Affinity DataKi:  0.501nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataKi:  0.501nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113477(CHEMBL3603924 | US10246432, Example 3 | US10584111...)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113479(CHEMBL3603926 | US10246432, Example 22 | US1058411...)
Affinity DataKi:  0.794nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113473(CHEMBL3603920 | US10246432, Example 1 | US10584111...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113478(CHEMBL3603925 | US10246432, Example 20 | US1058411...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113475(CHEMBL3603922 | US10246432, Example 18 | US1058411...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113474(CHEMBL3603921 | US10246432, Example 19 | US1058411...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113472(CHEMBL3603919 | US10246432, Example 2 | US10584111...)
Affinity DataKi:  3.20nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113467(CHEMBL3603914 | US10246432, Example 14 | US1058411...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113466(CHEMBL3603913 | US10246432, Example 13 | US1058411...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113481(CHEMBL3603928)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50443085(AFQ056 | Mavoglurant)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113480(CHEMBL3603927 | US10246432, Example 5 | US10584111...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113470(CHEMBL3603917)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113471(CHEMBL3603918)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113469(CHEMBL3603916)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113341(CHEMBL3603907)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113316(CHEMBL3603908)
Affinity DataKi:  251nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113350(CHEMBL3603909)
Affinity DataKi:  794nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113351(CHEMBL3603910)
Affinity DataKi:  7.94E+3nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113465(CHEMBL3603912)
Affinity DataKi: <6.31E+4nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113464(CHEMBL3603911)
Affinity DataKi: <6.31E+4nMAssay Description:Displacement of [3H]-M-MPEP from human mGlu5 receptor expressed in HEK293 cells after 90 mins by scintillation spectroscopy analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50613663(CHEMBL5287633)
Affinity DataIC50:  0.0500nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM256277(US9487488, 1)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at TRPM8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113479(CHEMBL3603926 | US10246432, Example 22 | US1058411...)
Affinity DataIC50:  0.398nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113476(CHEMBL3603923 | US10246432, Example 17 | US1058411...)
Affinity DataIC50:  0.631nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113477(CHEMBL3603924 | US10246432, Example 3 | US10584111...)
Affinity DataIC50:  0.631nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50335157(3-[7-Trifluoromethyl-5-(2-trifluoromethyl-phenyl)-...)
Affinity DataIC50:  0.800nMAssay Description:Antagonist activity at human TRMP8 incubated for 24 hrsMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50426573(CHEMBL2324349 | US9434711, 306)
Affinity DataIC50:  1.10nMAssay Description:Agonist activity at human TRMP8 expressed in HEK293 cells measured after 24 hrs of menthol activation by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113473(CHEMBL3603920 | US10246432, Example 1 | US10584111...)
Affinity DataIC50:  1.60nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50426573(CHEMBL2324349 | US9434711, 306)
Affinity DataIC50:  2.30nMAssay Description:Agonist activity at human TRMP8 expressed in HEK293 cells measured after 24 hrs of cold activation by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113475(CHEMBL3603922 | US10246432, Example 18 | US1058411...)
Affinity DataIC50:  2.5nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113472(CHEMBL3603919 | US10246432, Example 2 | US10584111...)
Affinity DataIC50:  2.5nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113468(CHEMBL3603915 | US10246432, Example 15 | US1058411...)
Affinity DataIC50:  2.5nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113478(CHEMBL3603925 | US10246432, Example 20 | US1058411...)
Affinity DataIC50:  3.20nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM241619(US9409915, 11 | US9718820, Compound 11)
Affinity DataIC50:  3.5nMAssay Description:Antagonist activity at human TRMP8 incubated for 24 hrsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50426573(CHEMBL2324349 | US9434711, 306)
Affinity DataIC50:  4nMAssay Description:Agonist activity at human TRMP8 expressed in HEK293 cells incubated for 24 hrs by HTS assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50613641(CHEMBL5286610)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at human TRPM8 expressed in CHO cellsMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113474(CHEMBL3603921 | US10246432, Example 19 | US1058411...)
Affinity DataIC50:  5nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113467(CHEMBL3603914 | US10246432, Example 14 | US1058411...)
Affinity DataIC50:  5nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50613656(CHEMBL5272167)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at human TRMP8 incubated for 24 hrsMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613657(CHEMBL5280890)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at human TRMP8 incubated for 24 hrsMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50331290(CHEMBL1289953 | N-(3-aminopropyl)-2-(3-methylbenzy...)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at TRPM8 (unknown origin) assessed as reduction in calcium influxMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50036517(CHEMBL3353597)
Affinity DataIC50:  8.30nMAssay Description:Antagonist activity at TRPM8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50613655(CHEMBL5274341)
Affinity DataIC50:  9nMAssay Description:Agonist activity at human TRMP8 expressed in HEK293 cells incubated for 24 hrs by HTS assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50443085(AFQ056 | Mavoglurant)
Affinity DataIC50:  10nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
LigandPNGBDBM50613665(CHEMBL5266721)
Affinity DataIC50: <10nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as reduction in menthol induced calcium influxMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613642(CHEMBL5270507)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at cold activated human TRPM8 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Heptares Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113466(CHEMBL3603913 | US10246432, Example 13 | US1058411...)
Affinity DataIC50:  13nMAssay Description:Negative allosteric modulation at human mGlu5 receptor expressed in HEK293 cells assessed as inhibition of L-quisqualic acid-induced inositol phospha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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