TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama
Curated by ChEMBL
University Of Alabama
Curated by ChEMBL
Affinity DataKi: 1.30nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama
Curated by ChEMBL
University Of Alabama
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama
Curated by ChEMBL
University Of Alabama
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama
Curated by ChEMBL
University Of Alabama
Curated by ChEMBL
Affinity DataKi: 3.30nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama
Curated by ChEMBL
University Of Alabama
Curated by ChEMBL
Affinity DataKi: 3.60nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama
Curated by ChEMBL
University Of Alabama
Curated by ChEMBL
Affinity DataKi: 4.75nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by Lineweaver-Burk plotMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama
Curated by ChEMBL
University Of Alabama
Curated by ChEMBL
Affinity DataKi: 5.68nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by Lineweaver-Burk plotMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama
Curated by ChEMBL
University Of Alabama
Curated by ChEMBL
Affinity DataKi: 6.60nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.60nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 11.8nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 24.5nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama
Curated by ChEMBL
University Of Alabama
Curated by ChEMBL
Affinity DataKi: 24.9nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 49.8nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 188nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama
Curated by ChEMBL
University Of Alabama
Curated by ChEMBL
Affinity DataIC50: 20.2nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama
Curated by ChEMBL
University Of Alabama
Curated by ChEMBL
Affinity DataIC50: 23.8nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama
Curated by ChEMBL
University Of Alabama
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama
Curated by ChEMBL
University Of Alabama
Curated by ChEMBL
Affinity DataIC50: 27.1nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama
Curated by ChEMBL
University Of Alabama
Curated by ChEMBL
Affinity DataIC50: 57.5nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama
Curated by ChEMBL
University Of Alabama
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 68.3nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 80.9nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 85.5nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 93.5nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 175nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 357nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama
Curated by ChEMBL
University Of Alabama
Curated by ChEMBL
Affinity DataIC50: 422nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
TargetNH(3)-dependent NAD(+) synthetase(Bacillus subtilis)
University Of Alabama At Birmingham
Curated by ChEMBL
University Of Alabama At Birmingham
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against Bacillus subtilis NAD synthetaseMore data for this Ligand-Target Pair
TargetNH(3)-dependent NAD(+) synthetase(Bacillus subtilis)
University Of Alabama At Birmingham
Curated by ChEMBL
University Of Alabama At Birmingham
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against Bacillus subtilis NAD synthetaseMore data for this Ligand-Target Pair
TargetNH(3)-dependent NAD(+) synthetase(Bacillus subtilis)
University Of Alabama At Birmingham
Curated by ChEMBL
University Of Alabama At Birmingham
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against Bacillus subtilis NAD synthetaseMore data for this Ligand-Target Pair
TargetNH(3)-dependent NAD(+) synthetase(Bacillus subtilis)
University Of Alabama At Birmingham
Curated by ChEMBL
University Of Alabama At Birmingham
Curated by ChEMBL
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against Bacillus subtilis NAD synthetaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation
US Patent
Uab Research Foundation
US Patent
Affinity DataIC50: 2.70E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation
US Patent
Uab Research Foundation
US Patent
Affinity DataIC50: 2.70E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation
US Patent
Uab Research Foundation
US Patent
Affinity DataIC50: 4.60E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University Of Alabama At Birmingham
Curated by ChEMBL
University Of Alabama At Birmingham
Curated by ChEMBL
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of neonatal Nav1.5 in human MDA-MB-231 cells assessed as reduction in inward sodium peak current at -100 mV holding potential after 5 to 1...More data for this Ligand-Target Pair
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation
US Patent
Uab Research Foundation
US Patent
Affinity DataIC50: 5.50E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University Of Alabama At Birmingham
Curated by ChEMBL
University Of Alabama At Birmingham
Curated by ChEMBL
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of neonatal Nav1.5 in human MDA-MB-231 cells assessed as reduction in inward sodium peak current at -100 mV holding potential after 5 to 1...More data for this Ligand-Target Pair
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation
US Patent
Uab Research Foundation
US Patent
Affinity DataIC50: 8.30E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation
US Patent
Uab Research Foundation
US Patent
Affinity DataIC50: 8.30E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation
US Patent
Uab Research Foundation
US Patent
Affinity DataIC50: 8.40E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation
US Patent
Uab Research Foundation
US Patent
Affinity DataIC50: 8.40E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation
US Patent
Uab Research Foundation
US Patent
Affinity DataIC50: 8.60E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation
US Patent
Uab Research Foundation
US Patent
Affinity DataIC50: 8.60E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
TargetNH(3)-dependent NAD(+) synthetase(Bacillus subtilis)
University Of Alabama At Birmingham
Curated by ChEMBL
University Of Alabama At Birmingham
Curated by ChEMBL
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibitory activity against Bacillus subtilis NAD synthetaseMore data for this Ligand-Target Pair
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation
US Patent
Uab Research Foundation
US Patent
Affinity DataIC50: 9.60E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation
US Patent
Uab Research Foundation
US Patent
Affinity DataIC50: 9.60E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation
US Patent
Uab Research Foundation
US Patent
Affinity DataIC50: 9.60E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation
US Patent
Uab Research Foundation
US Patent
Affinity DataIC50: 9.60E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair