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Found 312 with Last Name = 'velu' and Initial = 'se'
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320792(CHEMBL1165388 | Ethyl4-(5-[(2,4-diamino-6-quinazol...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320791(6-[(3,4-Dimethoxyanilino)methyl]-2,4-quinazolinedi...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320793(CHEMBL1165305 | Methyl5-(5-[(2,4-diamino-6-quinazo...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320794(CHEMBL1165306 | Methyl4-[(5-[(2,4-diamino-6-quinaz...)
Affinity DataKi:  3.30nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320790(4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-m...)
Affinity DataKi:  3.60nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320791(6-[(3,4-Dimethoxyanilino)methyl]-2,4-quinazolinedi...)
Affinity DataKi:  4.75nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320792(CHEMBL1165388 | Ethyl4-(5-[(2,4-diamino-6-quinazol...)
Affinity DataKi:  5.68nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by Lineweaver-Burk plotMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataKi:  6.60nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320792(CHEMBL1165388 | Ethyl4-(5-[(2,4-diamino-6-quinazol...)
Affinity DataKi:  9.60nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320791(6-[(3,4-Dimethoxyanilino)methyl]-2,4-quinazolinedi...)
Affinity DataKi:  11.8nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320793(CHEMBL1165305 | Methyl5-(5-[(2,4-diamino-6-quinazo...)
Affinity DataKi:  13nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320794(CHEMBL1165306 | Methyl4-[(5-[(2,4-diamino-6-quinaz...)
Affinity DataKi:  24.5nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320789(CHEMBL1164234 | methyl5-{5-[[(2,4-diamino-6-quinaz...)
Affinity DataKi:  24.9nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320790(4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-m...)
Affinity DataKi:  49.8nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320789(CHEMBL1164234 | methyl5-{5-[[(2,4-diamino-6-quinaz...)
Affinity DataKi:  188nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  20.2nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320792(CHEMBL1165388 | Ethyl4-(5-[(2,4-diamino-6-quinazol...)
Affinity DataIC50:  23.8nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320793(CHEMBL1165305 | Methyl5-(5-[(2,4-diamino-6-quinazo...)
Affinity DataIC50:  27nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320791(6-[(3,4-Dimethoxyanilino)methyl]-2,4-quinazolinedi...)
Affinity DataIC50:  27.1nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320794(CHEMBL1165306 | Methyl4-[(5-[(2,4-diamino-6-quinaz...)
Affinity DataIC50:  57.5nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320790(4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-m...)
Affinity DataIC50:  61nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320792(CHEMBL1165388 | Ethyl4-(5-[(2,4-diamino-6-quinazol...)
Affinity DataIC50:  68.3nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM18268(5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)
Affinity DataIC50:  80.9nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320791(6-[(3,4-Dimethoxyanilino)methyl]-2,4-quinazolinedi...)
Affinity DataIC50:  85.5nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320793(CHEMBL1165305 | Methyl5-(5-[(2,4-diamino-6-quinazo...)
Affinity DataIC50:  93.5nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320794(CHEMBL1165306 | Methyl4-[(5-[(2,4-diamino-6-quinaz...)
Affinity DataIC50:  175nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320790(4-(5-[(2,4-diamino-6-quinazolinyl)methyl]amino-2-m...)
Affinity DataIC50:  357nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Trypanosoma cruzi)
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320789(CHEMBL1164234 | methyl5-{5-[[(2,4-diamino-6-quinaz...)
Affinity DataIC50:  422nMAssay Description:Inhibition of Trypanosoma cruzi DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNH(3)-dependent NAD(+) synthetase(Bacillus subtilis)
University Of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against Bacillus subtilis NAD synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNH(3)-dependent NAD(+) synthetase(Bacillus subtilis)
University Of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50130829(CHEMBL1164 | Dimocillin sodium | Meticillin sodium...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against Bacillus subtilis NAD synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNH(3)-dependent NAD(+) synthetase(Bacillus subtilis)
University Of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50370232(BA-41166E | L-5103 | RIFAMPIN | Rifadin | Rifampic...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against Bacillus subtilis NAD synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNH(3)-dependent NAD(+) synthetase(Bacillus subtilis)
University Of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50366389(GENTAMICIN)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory activity against Bacillus subtilis NAD synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Alabama

Curated by ChEMBL
LigandPNGBDBM50320789(CHEMBL1164234 | methyl5-{5-[[(2,4-diamino-6-quinaz...)
Affinity DataIC50:  1.34E+3nMAssay Description:Inhibition of human DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation

US Patent
LigandPNGBDBM643909(US11866416, Compound SN-I-238D | US11866416, Compo...)
Affinity DataIC50:  2.70E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation

US Patent
LigandPNGBDBM643909(US11866416, Compound SN-I-238D | US11866416, Compo...)
Affinity DataIC50:  2.70E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation

US Patent
LigandPNGBDBM644003(US11866416, Compound SN-II-50)
Affinity DataIC50:  4.60E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University Of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50461651(CHEMBL4226210)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of neonatal Nav1.5 in human MDA-MB-231 cells assessed as reduction in inward sodium peak current at -100 mV holding potential after 5 to 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation

US Patent
LigandPNGBDBM644015(US11866416, Compound SN-II-105)
Affinity DataIC50:  5.50E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
University Of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50461652(CHEMBL4229014)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of neonatal Nav1.5 in human MDA-MB-231 cells assessed as reduction in inward sodium peak current at -100 mV holding potential after 5 to 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation

US Patent
LigandPNGBDBM644024(US11866416, Compound LC-I-205)
Affinity DataIC50:  8.30E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation

US Patent
LigandPNGBDBM644024(US11866416, Compound LC-I-205)
Affinity DataIC50:  8.30E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation

US Patent
LigandPNGBDBM50036936(3'',4''-Dimethoxy-Aurone | 3',4'-DIMETHOXY-AURONE ...)
Affinity DataIC50:  8.40E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation

US Patent
LigandPNGBDBM50036936(3'',4''-Dimethoxy-Aurone | 3',4'-DIMETHOXY-AURONE ...)
Affinity DataIC50:  8.40E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation

US Patent
LigandPNGBDBM643896(US11866416, Compound SN-I-225C | US11866416, Compo...)
Affinity DataIC50:  8.60E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation

US Patent
LigandPNGBDBM643896(US11866416, Compound SN-I-225C | US11866416, Compo...)
Affinity DataIC50:  8.60E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNH(3)-dependent NAD(+) synthetase(Bacillus subtilis)
University Of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM92599(CHEMBL263057 | NAD Synthetase Inhibitor, 4)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibitory activity against Bacillus subtilis NAD synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation

US Patent
LigandPNGBDBM643893(US11866416, Compound SN-I-217)
Affinity DataIC50:  9.60E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation

US Patent
LigandPNGBDBM643893(US11866416, Compound SN-I-217)
Affinity DataIC50:  9.60E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation

US Patent
LigandPNGBDBM644013(US11866416, Compound SN-II-81Cl | US11866416, Comp...)
Affinity DataIC50:  9.60E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBiofilm regulatory protein A(Streptococcus mutans serotype c (strain ATCC 70061...)
Uab Research Foundation

US Patent
LigandPNGBDBM643893(US11866416, Compound SN-I-217)
Affinity DataIC50:  9.60E+3nMAssay Description:A previously reported zymographic assay was utilized for the investigation of Gtf enzymatic activity, as described in Example 1. A 1:100 in fresh 5 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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