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Found 125 with Last Name = 'venet' and Initial = 'm'
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127246(8-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of Geranylgeranylprotein transferase-I at 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127246(8-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataIC50:  0.550nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataIC50:  0.550nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163613((2,3-Dihydro-1H-cyclopenta[b]quinolin-7-yl)-(4-met...)
Affinity DataIC50:  0.560nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136383((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Geranylgeranylprotein transferase-I catalyzed incorporation of [3H]-GGPP into biotinYRASNRSCAIL peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136383((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50126335(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM14434(6-[amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl...)
Affinity DataIC50:  0.860nMpH: 7.5 T: 2°CAssay Description:Compounds were tested as inhibitors of FTase in vitro using purified human enzyme to catalyze the reaction between [3H] FPP and a biotinylated peptid...More data for this Ligand-Target Pair
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50126335(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50126335(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136377(4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-(4-methyl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163596((2-Amino-3-ethyl-quinolin-6-yl)-(4-methoxy-cyclohe...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127248(6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136375(6-[Amino-(4-chloro-phenyl)-(4-methyl-4H-[1,2,4]tri...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136385(C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-1-methy...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127252(8-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136384((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136384((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of Geranylgeranylprotein transferase-I catalyzed incorporation of [3H]-GGPP into biotinYRASNRSCAIL peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136379(4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127254(9-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163617((2,3-Dihydro-thieno[2,3-b]quinolin-6-yl)-(4-methox...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163617((2,3-Dihydro-thieno[2,3-b]quinolin-6-yl)-(4-methox...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136376(4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-(3-methyl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163590((2,3-Diethyl-quinolin-6-yl)-(4-methoxy-cyclohexyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163589((4-Methoxy-cyclohexyl)-(2-propyl-quinolin-6-yl)-me...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163590((2,3-Diethyl-quinolin-6-yl)-(4-methoxy-cyclohexyl)...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataIC50:  3nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136389(C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-[1,2,4]...)
Affinity DataIC50:  3nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136384((4-chlorophenyl)(5-(3-chlorophenyl)tetrazolo[1,5-a...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of Geranylgeranylprotein transferase-I catalyzed incorporation of [3H]-GGPP into biotinYRASNRSCAIL peptideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127255(6-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163607(3-ethyl-6-[(4-methoxycyclohexyl)carbonyl]quinoline...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136378(4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(...)
Affinity DataIC50:  4nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136380(4-(3-Chloro-phenyl)-6-[1-(4-chloro-phenyl)-1-(3-me...)
Affinity DataIC50:  4nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163616((2-Chloro-3-ethyl-quinolin-6-yl)-(4-methoxy-cycloh...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163613((2,3-Dihydro-1H-cyclopenta[b]quinolin-7-yl)-(4-met...)
Affinity DataIC50:  4nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127247(1-(3-Chloro-phenyl)-9-[(4-chloro-phenyl)-hydroxy-(...)
Affinity DataIC50:  4nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163616((2-Chloro-3-ethyl-quinolin-6-yl)-(4-methoxy-cycloh...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163616((2-Chloro-3-ethyl-quinolin-6-yl)-(4-methoxy-cycloh...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136382(4-(3-Chloro-phenyl)-6-[1-(4-chloro-phenyl)-1-(4-me...)
Affinity DataIC50:  5nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163589((4-Methoxy-cyclohexyl)-(2-propyl-quinolin-6-yl)-me...)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136386(C-(4-Chloro-phenyl)-C-[5-(3-chloro-phenyl)-imidazo...)
Affinity DataIC50:  5nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50136381(4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(...)
Affinity DataIC50:  6nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163609((4-Methoxy-cyclohexyl)-(2-methyl-3-propyl-quinolin...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration against human metabotropic glutamate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163606(1-(3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-2-ph...)
Affinity DataIC50:  6nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127257(6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(...)
Affinity DataIC50:  6nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127249(6-(3-Chloro-phenyl)-8-[(4-chloro-phenyl)-hydroxy-(...)
Affinity DataIC50:  6nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50127250(6-[Amino-(4-chloro-phenyl)-(3-methyl-3H-imidazol-4...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of [3H]-FPP incorporation into biotinylated laminB peptide by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(RAT)
Janssen-Cilag

Curated by ChEMBL
LigandPNGBDBM50163611(1-(3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-2-th...)
Affinity DataIC50:  7nMAssay Description:Inhibitory concentration against rat metabotropic glutamate receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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