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Found 289 with Last Name = 'venkannagari' and Initial = 'h'
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50318567(2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...)
Affinity DataIC50:  4nMAssay Description:Inhibition of TNKS2More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50318567(2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...)
Affinity DataIC50:  11nMAssay Description:Inhibition of TNKS1More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50136772(CHEMBL3752492)
Affinity DataIC50:  37nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50136772(CHEMBL3752492)
Affinity DataIC50:  37nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(4-((1S,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Affinity DataIC50:  56nMAssay Description:Inhibition of TNKS2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50104286(CHEMBL3593715)
Affinity DataIC50:  71nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50104286(CHEMBL3593715)
Affinity DataIC50:  71nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50318567(2-(4-(Trifluoromethyl)phenyl)-7,8-dihydro-5H-thiop...)
Affinity DataIC50:  114nMAssay Description:Inhibition of PARP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50294835(4-((1S,2S,6R,7R)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*...)
Affinity DataIC50:  131nMAssay Description:Inhibition of TNKS1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50104288(CHEMBL3594137)
Affinity DataIC50:  150nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50104288(CHEMBL3594137)
Affinity DataIC50:  155nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
University Of Oulu

Curated by ChEMBL
LigandPNGBDBM50468579(CHEMBL4287262)
Affinity DataIC50:  180nMAssay Description:Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
University Of Oulu

Curated by ChEMBL
LigandPNGBDBM50468579(CHEMBL4287262)
Affinity DataIC50:  186nMAssay Description:Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50104287(CHEMBL3594136)
Affinity DataIC50:  230nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
University Of Oulu

Curated by ChEMBL
LigandPNGBDBM50452662(CHEMBL4208737)
Affinity DataIC50:  230nMAssay Description:Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50104287(CHEMBL3594136)
Affinity DataIC50:  234nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
University Of Oulu

Curated by ChEMBL
LigandPNGBDBM50452662(CHEMBL4208737)
Affinity DataIC50:  234nMAssay Description:Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50136757(CHEMBL3753510)
Affinity DataIC50:  257nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50136757(CHEMBL3753510)
Affinity DataIC50:  260nMAssay Description:Inhibition of human TNKS2 by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP15 [460-656,Y598L](Homo sapiens (Human))
University of Oulu

LigandPNGBDBM199181(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Affinity DataIC50:  295nMAssay Description:This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50104285(CHEMBL3593716)
Affinity DataIC50:  300nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50104285(CHEMBL3593716)
Affinity DataIC50:  302nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10 [809-1017](Homo sapiens (Human))
University of Oulu

LigandPNGBDBM199181(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Affinity DataIC50:  329nMAssay Description:This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
University Of Oulu

Curated by ChEMBL
LigandPNGBDBM199181(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Affinity DataIC50:  330nMAssay Description:Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 1...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50104290(CHEMBL268379)
Affinity DataIC50:  355nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50104290(CHEMBL268379)
Affinity DataIC50:  360nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
University Of Oulu

Curated by ChEMBL
LigandPNGBDBM50136755(CHEMBL3752386)
Affinity DataIC50:  360nMAssay Description:Inhibition of tankyrase in WNT3a-stimulated human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50104286(CHEMBL3593715)
Affinity DataIC50:  370nMAssay Description:Inhibition of human TNKS1 (1030 to 1317) using NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
University Of Oulu

Curated by ChEMBL
LigandPNGBDBM50136756(CHEMBL3752054)
Affinity DataIC50:  380nMAssay Description:Inhibition of tankyrase in WNT3a-stimulated human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM150782(2-(4-Chlorophenyl)-2,3-dihydroquinazolin-4(1H)-one...)
Affinity DataIC50:  410nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM150782(2-(4-Chlorophenyl)-2,3-dihydroquinazolin-4(1H)-one...)
Affinity DataIC50:  417nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50441357(CHEMBL2431805)
Affinity DataIC50:  479nMAssay Description:Inhibition of human full length ARTD2 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50441357(CHEMBL2431805)
Affinity DataIC50:  479nMAssay Description:Inhibition of human full length ARTD2 using NAD+ as substrate by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50136772(CHEMBL3752492)
Affinity DataIC50:  550nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50136772(CHEMBL3752492)
Affinity DataIC50:  550nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50136755(CHEMBL3752386)
Affinity DataIC50:  562nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50136755(CHEMBL3752386)
Affinity DataIC50:  570nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50104293(CHEMBL3594132)
Affinity DataIC50:  575nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50104293(CHEMBL3594132)
Affinity DataIC50:  580nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP10 [809-1017,R931A](Homo sapiens (Human))
University of Oulu

LigandPNGBDBM199181(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Affinity DataIC50:  597nMAssay Description:This assay measures the substrate consumption by quantifying the remaining NAD+ through its chemical conversion to a stable fluorescent condensation ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
University Of Oulu

Curated by ChEMBL
LigandPNGBDBM199181(4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carbox...)
Affinity DataIC50:  600nMAssay Description:Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) R931A mutant expressed in Escherichia coli Rosetta2 (DE3) Rosetta2 (DE3) usin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50104288(CHEMBL3594137)
Affinity DataIC50:  620nMAssay Description:Inhibition of human TNKS1 (1030 to 1317) using NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50136756(CHEMBL3752054)
Affinity DataIC50:  690nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
University Of Oulu

Curated by ChEMBL
LigandPNGBDBM50136758(CHEMBL3753249)
Affinity DataIC50:  690nMAssay Description:Inhibition of tankyrase in WNT3a-stimulated human HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50136756(CHEMBL3752054)
Affinity DataIC50:  692nMAssay Description:Inhibition of human TNKS1 by fluorescence analysisMore data for this Ligand-Target Pair
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
University Of Oulu

Curated by ChEMBL
LigandPNGBDBM50468581(CHEMBL4287655)
Affinity DataIC50:  710nMAssay Description:Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
University Of Oulu

Curated by ChEMBL
LigandPNGBDBM50468581(CHEMBL4287655)
Affinity DataIC50:  710nMAssay Description:Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50104284(CHEMBL2144572)
Affinity DataIC50:  720nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Homo sapiens (Human))
University Of Oulu

Curated by ChEMBL
LigandPNGBDBM50468593(CHEMBL4277717)
Affinity DataIC50:  720nMAssay Description:Inhibition of C-terminal His-tagged human ARTD10 (809 to 1017 residues) expressed in Escherichia coli Rosetta2 (DE3) using SRPK2 as substrate after 1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Abo Akademi University

Curated by ChEMBL
LigandPNGBDBM50104284(CHEMBL2144572)
Affinity DataIC50:  724nMAssay Description:Inhibition of human TNKS2 (956 to 1161 and 873 to 1161) using 500 nM NAD substrate after 20 mins incubation by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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