TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Institute Of Bioorganic Chemistry Ras
Curated by ChEMBL
Institute Of Bioorganic Chemistry Ras
Curated by ChEMBL
Affinity DataKi: 380nMAssay Description:Concentration required to displace 0.4 nM [3H]-SR-141,716A from CB1 receptor in rat brain preparations in the presence of 0.1 mM phenylmethyl sulphon...More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Institute Of Bioorganic Chemistry Ras
Curated by ChEMBL
Institute Of Bioorganic Chemistry Ras
Curated by ChEMBL
Affinity DataKi: 620nMAssay Description:Concentration required to displace 0.4 nM [3H]-SR-141,716A from CB1 receptor in rat brain preparations in the presence of 0.1 mM phenylmethyl sulphon...More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Institute Of Bioorganic Chemistry Ras
Curated by ChEMBL
Institute Of Bioorganic Chemistry Ras
Curated by ChEMBL
Affinity DataKi: 800nMAssay Description:Concentration required to displace 0.4 nM [3H]-SR-141,716A from CB1 receptor in rat brain preparations in the presence of 0.1 mM phenylmethyl sulphon...More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Institute Of Bioorganic Chemistry Ras
Curated by ChEMBL
Institute Of Bioorganic Chemistry Ras
Curated by ChEMBL
Affinity DataKi: 1.37E+3nMAssay Description:Concentration required to displace 0.4 nM [3H]-SR-141,716A from CB1 receptor in rat brain preparations in the presence of 0.1 mM phenylmethyl sulphon...More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Institute Of Bioorganic Chemistry Ras
Curated by ChEMBL
Institute Of Bioorganic Chemistry Ras
Curated by ChEMBL
Affinity DataKi: 1.72E+3nMAssay Description:Concentration required to displace 0.4 nM [3H]-SR-141,716A from CB1 receptor in rat brain preparations in the presence of 0.1 mM phenylmethyl sulphon...More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Institute Of Bioorganic Chemistry Ras
Curated by ChEMBL
Institute Of Bioorganic Chemistry Ras
Curated by ChEMBL
Affinity DataKi: 2.43E+3nMAssay Description:Concentration required to displace 0.4 nM [3H]-SR-141,716A from CB1 receptor in rat brain preparations in the presence of 0.1 mM phenylmethyl sulphon...More data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Institute Of Bioorganic Chemistry Ras
Curated by ChEMBL
Institute Of Bioorganic Chemistry Ras
Curated by ChEMBL
Affinity DataKi: 3.13E+3nMAssay Description:Concentration required to displace 0.4 nM [3H]-SR-141,716A from CB1 receptor in rat brain preparations in the presence of 0.1 mM phenylmethyl sulphon...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Institut Pasteur
Curated by ChEMBL
Institut Pasteur
Curated by ChEMBL
Affinity DataIC50: 0.794nMAssay Description:Inhibition of His-tagged human DHODH assessed as reduction of DCIP by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of Fc-fused BACE1 (1 to 460 residues) (unknown origin) expressed in HEK293 cells using mcaFRET peptide as substrate after 20 hrs by fluore...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Institut Pasteur
Curated by ChEMBL
Institut Pasteur
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Institut Pasteur
Curated by ChEMBL
Institut Pasteur
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Institut Pasteur
Curated by ChEMBL
Institut Pasteur
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human purified recombinant DHODHMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Institut Pasteur
Curated by ChEMBL
Institut Pasteur
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of His-tagged human DHODH assessed as reduction of DCIP by spectrophotometryMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Institut Pasteur
Curated by ChEMBL
Institut Pasteur
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of His-tagged human DHODH assessed as reduction of DCIP by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293-APP751swe cells assessed as reduction in amyloid beta (1 to 40) level by sandwich-ELISA meth...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Institut Pasteur
Curated by ChEMBL
Institut Pasteur
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of His-tagged human DHODH assessed as reduction of DCIP by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293-APP751swe cells assessed as reduction in amyloid beta (1 to 40) level by sandwich-ELISA meth...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Institut Pasteur
Curated by ChEMBL
Institut Pasteur
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of His-tagged human DHODH assessed as reduction of DCIP by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Compound was tested for inhibition against binding of radioligand [3H]-LTB4 to Leukotriene B4 receptor in human neutrophil membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of Fc-fused BACE1 (1 to 460 residues) (unknown origin) expressed in HEK293 cells using mcaFRET peptide as substrate after 20 hrs by fluore...More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)More data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of Fc-fused BACE1 (1 to 460 residues) (unknown origin) expressed in HEK293 cells using mcaFRET peptide as substrate after 20 hrs by fluore...More data for this Ligand-Target Pair
Affinity DataIC50: 99nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293-APP751swe cells assessed as reduction in amyloid beta (1 to 40) level by sandwich-ELISA meth...More data for this Ligand-Target Pair
Affinity DataIC50: 101nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293-APP751swe cells assessed as reduction in amyloid beta (1 to 40) level by sandwich-ELISA meth...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Institut Pasteur
Curated by ChEMBL
Institut Pasteur
Curated by ChEMBL
Affinity DataIC50: 126nMAssay Description:Inhibition of His-tagged human DHODH assessed as reduction of DCIP by spectrophotometryMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
Institut Pasteur
Curated by ChEMBL
Institut Pasteur
Curated by ChEMBL
Affinity DataIC50: 127nMAssay Description:Inhibition of rat recombinant His-tagged truncated DHODH expressed in Escherichia coli using dihydroorotate as substrate by chromogen reduction assayMore data for this Ligand-Target Pair
Affinity DataIC50: 205nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293-APP751swe cells assessed as reduction in amyloid beta (1 to 40) level by sandwich-ELISA meth...More data for this Ligand-Target Pair
Affinity DataIC50: 220nMAssay Description:Inhibition of Fc-fused BACE1 (1 to 460 residues) (unknown origin) expressed in HEK293 cells using mcaFRET peptide as substrate after 20 hrs by fluore...More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Compound was tested for inhibition against binding of radioligand [3H]-LTB4 to Leukotriene B4 receptor in human neutrophil membranesMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
Institut Pasteur
Curated by ChEMBL
Institut Pasteur
Curated by ChEMBL
Affinity DataIC50: 367nMAssay Description:Inhibition of rat purified recombinant DHODHMore data for this Ligand-Target Pair
Affinity DataIC50: 480nMAssay Description:Inhibition of Fc-fused BACE1 (1 to 460 residues) (unknown origin) expressed in HEK293 cells using mcaFRET peptide as substrate after 20 hrs by fluore...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)More data for this Ligand-Target Pair
Affinity DataIC50: 530nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293-APP751swe cells assessed as reduction in amyloid beta (1 to 40) level by sandwich-ELISA meth...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
Institut Pasteur
Curated by ChEMBL
Institut Pasteur
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of rat purified recombinant DHODHMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)More data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293-APP751swe cells assessed as reduction in amyloid beta (1 to 40) level by sandwich-ELISA meth...More data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Compound was evaluated for inhibitory activity against LTB4 receptor in human neutrophil membranes using [3H]- LTB4 as radioligandMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Institut Pasteur
Curated by ChEMBL
Institut Pasteur
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human recombinant DHODHMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)More data for this Ligand-Target Pair
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of Fc-fused BACE1 (1 to 460 residues) (unknown origin) expressed in HEK293 cells using mcaFRET peptide as substrate after 20 hrs by fluore...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of Fc-fused BACE1 (1 to 460 residues) (unknown origin) expressed in HEK293 cells using mcaFRET peptide as substrate after 20 hrs by fluore...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of binding of [3H]LTB4 (1 nM) to intact human polymorphonuclear leukocytes (PMNs)More data for this Ligand-Target Pair
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in HEK293-APP751swe cells assessed as reduction in amyloid beta (1 to 40) level by sandwich-ELISA meth...More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Compound was tested for inhibition against binding of radioligand [3H]-LTB4 to Leukotriene B4 receptor in human neutrophil membranesMore data for this Ligand-Target Pair