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Found 71 with Last Name = 'vigushin' and Initial = 'dm'
TargetHistone deacetylase 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50196604(CHEMBL217083 | N-hydroxy-7-(naphthalen-2-yloxy)hep...)
Affinity DataIC50:  0.900nMAssay Description:In vitro inhibition of histone deacetylase activity using HeLa cell nuclear extract as enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50196608(7-(4-((4-chlorobenzyl)(methyl)amino)phenoxy)-N-hyd...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of histone deacetylase activity using HeLa cell nuclear extract as enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50196600(7-(1H-indol-5-yloxy)-N-hydroxyheptanamide | CHEMBL...)
Affinity DataIC50:  3.60nMAssay Description:In vitro inhibition of histone deacetylase activity using HeLa cell nuclear extract as enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataIC50:  5nMAssay Description:Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extractMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50196598(7-(4-(3-(1H-indol-3-yl)prop-1-en-2-ylamino)phenyl1...)
Affinity DataIC50:  6.20nMAssay Description:In vitro inhibition of histone deacetylase activity using HeLa cell nuclear extract as enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50196605(7-(4-(2-(1H-indol-3-yl)acetamido)phenyl1H-indol-3-...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of histone deacetylase activity using HeLa cell nuclear extract as enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50196603(7-(4-(2-(1H-indol-3-yl)acetamido)-2-fluorophenyl1H...)
Affinity DataIC50:  13nMAssay Description:In vitro inhibition of histone deacetylase activity using HeLa cell nuclear extract as enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50196594(7-(4-((1H-indol-5-yl)methylamino)phenyl1H-indol-5-...)
Affinity DataIC50:  14nMAssay Description:In vitro inhibition of histone deacetylase activity using HeLa cell nuclear extract as enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50196597(CHEMBL384714 | N-hydroxy-7-(4-(methyl(pyridin-4-yl...)
Affinity DataIC50:  15nMAssay Description:In vitro inhibition of histone deacetylase activity using HeLa cell nuclear extract as enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50196609(7-(4-(3-(1H-indol-3-yl)propanamido)phenyl1H-indol-...)
Affinity DataIC50:  16nMAssay Description:In vitro inhibition of histone deacetylase activity using HeLa cell nuclear extract as enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50196607(7-(4-(3-(1H-indol-3-yl)-N-(pyridin-4-ylmethyl)prop...)
Affinity DataIC50:  16nMAssay Description:In vitro inhibition of histone deacetylase activity using HeLa cell nuclear extract as enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50196602(7-(4-(dimethylamino)phenoxy)-N-hydroxyheptanamide ...)
Affinity DataIC50:  19nMAssay Description:In vitro inhibition of histone deacetylase activity using HeLa cell nuclear extract as enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50196593(CHEMBL387042 | N-hydroxy-7-(4-((3-hydroxy-5-(hydro...)
Affinity DataIC50:  22nMAssay Description:In vitro inhibition of histone deacetylase activity using HeLa cell nuclear extract as enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50196596(8-(4-(2-(1H-indol-3-yl)acetamido)phenyl1H-indol-3-...)
Affinity DataIC50:  22nMAssay Description:In vitro inhibition of histone deacetylase activity using HeLa cell nuclear extract as enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50196601(CHEMBL217778 | N-hydroxy-7-(4-(4-methoxyphenylsulf...)
Affinity DataIC50:  22nMAssay Description:In vitro inhibition of histone deacetylase activity using HeLa cell nuclear extract as enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50196606(7-(4-(2-(1H-indol-3-yl)acetamido)-3-fluorophenyl1H...)
Affinity DataIC50:  24nMAssay Description:In vitro inhibition of histone deacetylase activity using HeLa cell nuclear extract as enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50223405(CHEMBL316183)
Affinity DataIC50:  49nMAssay Description:Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extractMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50196595(6-(4-(2-(1H-indol-3-yl)acetamido)phenyl1H-indol-3-...)
Affinity DataIC50:  50nMAssay Description:In vitro inhibition of histone deacetylase activity using HeLa cell nuclear extract as enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50196599(7-(3-fluoro-4-((3-hydroxy-5-(hydroxymethyl)-2-meth...)
Affinity DataIC50:  70nMAssay Description:In vitro inhibition of histone deacetylase activity using HeLa cell nuclear extract as enzyme sourceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50223410(CHEMBL82931)
Affinity DataIC50:  74nMAssay Description:Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extractMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50223409(CHEMBL314643)
Affinity DataIC50:  172nMAssay Description:Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extractMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50223408(CHEMBL312098)
Affinity DataIC50:  252nMAssay Description:Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extractMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50223416(CHEMBL84395)
Affinity DataIC50:  279nMAssay Description:Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extractMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50223411(CHEMBL81522)
Affinity DataIC50:  302nMAssay Description:Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extractMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50223407(CHEMBL82989)
Affinity DataIC50:  788nMAssay Description:Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extractMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50223406(CHEMBL312400)
Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extractMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50223414(CHEMBL83750)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extractMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50123957((E)-5-(3-Benzenesulfonylamino-phenyl)-pent-2-en-4-...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extractMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50223412(CHEMBL84288)
Affinity DataIC50:  2.58E+3nMAssay Description:Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extractMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50108509(5-((E)-4,8-Dimethyl-nona-3,7-dienyl)-3a,4,7,7a-tet...)
Affinity DataIC50:  9.00E+3nMAssay Description:Binding affinity for human cloned Histamine H1 receptor expressed in CHO cells using [3H]pyrilamine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50223413(CHEMBL82382)
Affinity DataIC50:  1.04E+4nMAssay Description:Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extractMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50134315(7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-...)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of [3H]-GGPP incorporation into recombinant human Ha-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50108512(5-(4,8,12-Trimethyl-tridecyl)-3a,4,7,7a-tetrahydro...)
Affinity DataIC50:  2.08E+4nMAssay Description:Binding affinity for human cloned 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50108511(5-(4-Methyl-pent-3-enyl)-3a,4,7,7a-tetrahydro-isob...)
Affinity DataIC50:  4.02E+4nMAssay Description:In vitro inhibition of geranylgeranyl-protein transferase type-IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50134315(7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-...)
Affinity DataIC50:  8.00E+4nMAssay Description:Inhibition of [3H]-FPP incorporation into recombinant human Ha-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50134312(CHEMBL120863 | Thioacetic acid S-(9-methoxy-2-meth...)
Affinity DataIC50:  9.03E+4nMAssay Description:Inhibition of [3H]-GGPP incorporation into recombinant human Ha-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50059863((Z)-2-Methyl-3-tetradecyl-but-2-enedioic acid | CH...)
Affinity DataIC50:  9.20E+4nMAssay Description:In vitro inhibition of geranylgeranyl-protein transferase type-IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50134311(3-Benzyldisulfanyl-9-methoxy-2-methyl-2,3-dihydro-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [3H]-GGPP incorporation into recombinant human Ha-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50134308(3-Benzyldisulfanyl-2-methyl-2,3-dihydro-pyrazino[1...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [3H]-FPP incorporation into recombinant human Ha-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50134313(2-Methyl-2,3-dihydro-pyrazino[1,2-a]indole-1,4-dio...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [3H]-FPP incorporation into recombinant human Ha-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50134314(9-Methoxy-2-methyl-2,3-dihydro-pyrazino[1,2-a]indo...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [3H]-FPP incorporation into recombinant human Ha-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50134311(3-Benzyldisulfanyl-9-methoxy-2-methyl-2,3-dihydro-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [3H]-FPP incorporation into recombinant human Ha-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50134309(2-Methyl-2,3,10,10a-tetrahydro-pyrazino[1,2-a]indo...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [3H]-FPP incorporation into recombinant human Ha-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50134313(2-Methyl-2,3-dihydro-pyrazino[1,2-a]indole-1,4-dio...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [3H]-GGPP incorporation into recombinant human Ha-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50134310(9-Methoxy-2-methyl-2,3,10,10a-tetrahydro-pyrazino[...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [3H]-GGPP incorporation into recombinant human Ha-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50134314(9-Methoxy-2-methyl-2,3-dihydro-pyrazino[1,2-a]indo...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [3H]-GGPP incorporation into recombinant human Ha-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50134309(2-Methyl-2,3,10,10a-tetrahydro-pyrazino[1,2-a]indo...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [3H]-GGPP incorporation into recombinant human Ha-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50134308(3-Benzyldisulfanyl-2-methyl-2,3-dihydro-pyrazino[1...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [3H]-GGPP incorporation into recombinant human Ha-Ras-CVLL by Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50223415(CHEMBL312253)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of histone deacetylase (HDAC) activity in HeLa cell nuclear extractMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
University College London

Curated by ChEMBL
LigandPNGBDBM50134310(9-Methoxy-2-methyl-2,3,10,10a-tetrahydro-pyrazino[...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of [3H]-FPP incorporation into recombinant human Ha-Ras-CVLS by farnesyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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