Affinity DataIC50: 4nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 10nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 20nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 700nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 3.74E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate incubated for 10 to 30 mins in presence of NADPH by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: >4.70E+3nMAssay Description:Inhibition of human ERG by manual patch clamp methodMore data for this Ligand-Target Pair
Affinity DataIC50: 6.23E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate incubated for 10 to 30 mins in presence of NADPH by LC-MS/MS methodMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
TargetDNA polymerase beta(Homo sapiens (Human))
Novartis Institute For Tropical Diseases
Curated by ChEMBL
Novartis Institute For Tropical Diseases
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human DNA polymerase betaMore data for this Ligand-Target Pair
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Novartis Institute For Tropical Diseases
Curated by ChEMBL
Novartis Institute For Tropical Diseases
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human DNA polymerase alphaMore data for this Ligand-Target Pair
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate incubated for 10 to 30 mins in presence of NADPH by LC-MS/MS methodMore data for this Ligand-Target Pair
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Novartis Institute For Tropical Diseases
Curated by ChEMBL
Novartis Institute For Tropical Diseases
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human DNA polymerase alphaMore data for this Ligand-Target Pair
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Novartis Institute For Tropical Diseases
Curated by ChEMBL
Novartis Institute For Tropical Diseases
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human DNA polymerase alphaMore data for this Ligand-Target Pair
TargetDNA polymerase beta(Homo sapiens (Human))
Novartis Institute For Tropical Diseases
Curated by ChEMBL
Novartis Institute For Tropical Diseases
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human DNA polymerase betaMore data for this Ligand-Target Pair
TargetDNA polymerase beta(Homo sapiens (Human))
Novartis Institute For Tropical Diseases
Curated by ChEMBL
Novartis Institute For Tropical Diseases
Curated by ChEMBL
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human DNA polymerase betaMore data for this Ligand-Target Pair