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Found 27 with Last Name = 'voshol' and Initial = 'h'
TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM608937(1-(6-{(4M)-4-(5-Chloro-6- methyl-1H-indazol-4-yl)-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM50609524(CHEMBL5281254)
Affinity DataIC50:  8nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM50609523(CHEMBL5271997)
Affinity DataIC50:  10nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM50579985(JDQ-443 | JDQ443 | Jdq 443 | Jdq-443 | Nvp-jdq-443...)
Affinity DataIC50:  20nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM608850(US11702409, Example 12a | US11702409, Example 12b)
Affinity DataIC50:  20nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM608886(1-{6-[(4M)-4-(5-Chloro-6- methyl-1H-indazol-4-yl)-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM608857(US11702409, Example 15a | US11702409, Example 15b)
Affinity DataIC50:  30nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM608856(US11702409, Example 14)
Affinity DataIC50:  50nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM608888(US11702409, Example 27a | US11702409, Example 27b)
Affinity DataIC50:  90nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM608896(US11702409, Example 30a | US11702409, Example 30b)
Affinity DataIC50:  140nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM608868(US11702409, Example 19a | US11702409, Example 19b)
Affinity DataIC50:  500nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM50609519(CHEMBL5266172)
Affinity DataIC50:  500nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM50609522(CHEMBL5291136)
Affinity DataIC50:  700nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM50609520(CHEMBL5269632)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
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TargetCytochrome P450 2C9(Homo sapiens (Human))TBA
LigandPNGBDBM50579985(JDQ-443 | JDQ443 | Jdq 443 | Jdq-443 | Nvp-jdq-443...)
Affinity DataIC50:  3.74E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate incubated for 10 to 30 mins in presence of NADPH by LC-MS/MS methodMore data for this Ligand-Target Pair
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TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM50609521(CHEMBL5283602)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 6 hrs by MSD assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50579985(JDQ-443 | JDQ443 | Jdq 443 | Jdq-443 | Nvp-jdq-443...)
Affinity DataIC50: >4.70E+3nMAssay Description:Inhibition of human ERG by manual patch clamp methodMore data for this Ligand-Target Pair
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TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM50579985(JDQ-443 | JDQ443 | Jdq 443 | Jdq-443 | Nvp-jdq-443...)
Affinity DataIC50:  6.23E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate incubated for 10 to 30 mins in presence of NADPH by LC-MS/MS methodMore data for this Ligand-Target Pair
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LigandPNGBDBM50579985(JDQ-443 | JDQ443 | Jdq 443 | Jdq-443 | Nvp-jdq-443...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
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TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50579985(JDQ-443 | JDQ443 | Jdq 443 | Jdq-443 | Nvp-jdq-443...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
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TargetDNA polymerase beta(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50300193(2-[3-(1-Benzyl-1H-pyrazol-3-yl)-benzenesulfonylami...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50300195(4-Fluoro-2-[3-(1-naphthalen-2-ylmethyl-1H-pyrazol-...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human DNA polymerase alphaMore data for this Ligand-Target Pair
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TargetCytochrome P450 2D6(Homo sapiens (Human))TBA
LigandPNGBDBM50579985(JDQ-443 | JDQ443 | Jdq 443 | Jdq-443 | Nvp-jdq-443...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using bufuralol as substrate incubated for 10 to 30 mins in presence of NADPH by LC-MS/MS methodMore data for this Ligand-Target Pair
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TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50300194(2-[3-(1-Benzyl-1H-pyrazol-3-yl)-benzenesulfonylami...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50300193(2-[3-(1-Benzyl-1H-pyrazol-3-yl)-benzenesulfonylami...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50300194(2-[3-(1-Benzyl-1H-pyrazol-3-yl)-benzenesulfonylami...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase beta(Homo sapiens (Human))
Novartis Institute For Tropical Diseases

Curated by ChEMBL
LigandPNGBDBM50300195(4-Fluoro-2-[3-(1-naphthalen-2-ylmethyl-1H-pyrazol-...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of human DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed