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Found 564 with Last Name = 'vyas' and Initial = 'dm'
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107016(US8592579, 219)
Affinity DataIC50:  1nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107013(US8592579, 211)
Affinity DataIC50:  1nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50325424((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  1nMAssay Description:Inhibition of IGF1R in IGF1R-SAL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107018(US8592579, 254)
Affinity DataIC50:  1nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107023(US8592579, 288)
Affinity DataIC50:  1nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107020(US8592579, 256)
Affinity DataIC50:  2nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107021(US8592579, 259)
Affinity DataIC50:  2nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50299138((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK2/Cyclin E after 60 mins by fluorescence electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50299148((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  2nMAssay Description:Inhibition of IGF1R after 60 mins by fluorescence electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107003(CHEMBL575447 | US8592579, 110)
Affinity DataIC50:  2nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107024(US8592579, 293)
Affinity DataIC50:  2nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107000(US8592579, 104)
Affinity DataIC50:  2nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107012(US8592579, 209)
Affinity DataIC50:  2nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107026(US8592579, 301)
Affinity DataIC50:  2nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50299143((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  2nMAssay Description:Inhibition of IGF1R after 60 mins by fluorescence electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50299148((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of IGF1R in IGF1R-SAL cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50325424((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107028(US8592579, 318)
Affinity DataIC50:  3nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM25960(amino-N-({3-[12-methyl-8-(methylamino)-3-thia-1,7,...)
Affinity DataIC50:  3nMAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107022(US8592579, 287)
Affinity DataIC50:  3nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107003(CHEMBL575447 | US8592579, 110)
Affinity DataIC50:  3nMAssay Description:Inhibition of IGF1R after 60 mins by fluorescence electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107001(US8592579, 105)
Affinity DataIC50:  4nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50299145((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  4nMAssay Description:Inhibition of IGF1R after 60 mins by fluorescence electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107015(US8592579, 216)
Affinity DataIC50:  5nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107025(US8592579, 294)
Affinity DataIC50:  5nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107017(US8592579, 243)
Affinity DataIC50:  5nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50325430(CHEMBL1222855 | N-((4-(5-cyclopropyl-1H-pyrazol-3-...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50299146((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  6nMAssay Description:Inhibition of IGF1R after 60 mins by fluorescence electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50325425((S)-(2-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrr...)
Affinity DataIC50:  7nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM25965(amino-N-(2-{3-[12-methyl-8-(methylamino)-3-thia-1,...)
Affinity DataIC50:  7nMAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107004(US8592579, 111)
Affinity DataIC50:  7nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM25970(2-{3-[12-methyl-8-(methylamino)-3-thia-1,7,10-tria...)
Affinity DataIC50:  8nMAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM25942((3-{8-[(2-aminoethyl)amino]-12-methyl-3-thia-1,7,1...)
Affinity DataIC50:  8nMAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50299148((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM25957(4-[3-(aminomethyl)phenyl]-N,12-dimethyl-3-thia-1,7...)
Affinity DataIC50:  8.5nMAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM25971(3-{3-[12-methyl-8-(methylamino)-3-thia-1,7,10-tria...)
Affinity DataIC50: <9nMAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50299144((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  9nMAssay Description:Inhibition of IGF1R after 60 mins by fluorescence electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50325428(CHEMBL1222791 | trans-2-(4-(5-cyclopropyl-1H-pyraz...)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50325428(CHEMBL1222791 | trans-2-(4-(5-cyclopropyl-1H-pyraz...)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM25934(N-(2-aminoethyl)-12-methyl-4-(1H-pyrazol-4-yl)-3-t...)
Affinity DataIC50:  10nMAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50325427((S)-5-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  11nMAssay Description:Inhibition of IGF1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Mus musculus)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50299148((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  13nMAssay Description:Inhibition of IGF1R phosphorylation in mouse Sal cells by western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM50299140((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  13nMAssay Description:Inhibition of IGF1R after 60 mins by fluorescence electrophoresisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM25973(2-amino-3-{3-[12-methyl-8-(methylamino)-3-thia-1,7...)
Affinity DataIC50:  13nMAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM25966(2-[(2-{3-[12-methyl-8-(methylamino)-3-thia-1,7,10-...)
Affinity DataIC50:  13nMAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50217195(5-((4-aminopiperidin-1-yl)methyl)-N-(1-((5-methylp...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant HER2 expressed in insect Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM25975((2S)-2-amino-3-{3-[12-methyl-8-(methylamino)-3-thi...)
Affinity DataIC50:  14nMAssay Description:Assays measuring the enzyme-catalyzed phosphorylation of GST-I kappa B alpha were performed. The phosphorylated substrate was detected using a Phosph...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107027(US8592579, 317)
Affinity DataIC50:  14nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM107002(US8592579, 107)
Affinity DataIC50:  16nMpH: 7.4Assay Description:Kinase assay using IGF1-receptor.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50208409((S)-1-((4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human HER2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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