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Found 57 with Last Name = 'wada' and Initial = 's'
TargetHistone deacetylase 1(Homo sapiens (Human))
Kindai University

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataIC50:  19nMAssay Description:Inhibition of recombinant human HDAC1 expressed in HEK293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presence of DTT by fluorescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataIC50:  28nMAssay Description:Inhibition of recombinant mouse HDAC6 expressed in HEK293T cells co-expressing mouse HDA2 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presen...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Mus musculus)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50460520(CHEMBL4228293)
Affinity DataIC50:  44nMAssay Description:Inhibition of recombinant mouse HDAC6 expressed in HEK293T cells co-expressing mouse HDA2 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50460521(CHEMBL4228332)
Affinity DataIC50:  51nMAssay Description:Inhibition of recombinant mouse HDAC6 expressed in HEK293T cells co-expressing mouse HDA2 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50460518(CHEMBL4228977)
Affinity DataIC50:  81nMAssay Description:Inhibition of recombinant mouse HDAC6 expressed in HEK293T cells co-expressing mouse HDA2 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50460523(CHEMBL4225627)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant mouse HDAC6 expressed in HEK293T cells co-expressing mouse HDA2 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50460524(CHEMBL4225893)
Affinity DataIC50:  560nMAssay Description:Inhibition of recombinant mouse HDAC6 expressed in HEK293T cells co-expressing mouse HDA2 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Kindai University

Curated by ChEMBL
LigandPNGBDBM50460518(CHEMBL4228977)
Affinity DataIC50:  590nMAssay Description:Inhibition of recombinant human HDAC1 expressed in HEK293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presence of DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50460522(CHEMBL4226829)
Affinity DataIC50:  590nMAssay Description:Inhibition of recombinant mouse HDAC6 expressed in HEK293T cells co-expressing mouse HDA2 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Kindai University

Curated by ChEMBL
LigandPNGBDBM50460521(CHEMBL4228332)
Affinity DataIC50:  730nMAssay Description:Inhibition of recombinant human HDAC1 expressed in HEK293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presence of DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Kindai University

Curated by ChEMBL
LigandPNGBDBM50460523(CHEMBL4225627)
Affinity DataIC50:  900nMAssay Description:Inhibition of recombinant human HDAC1 expressed in HEK293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presence of DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Kindai University

Curated by ChEMBL
LigandPNGBDBM50460520(CHEMBL4228293)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of recombinant human HDAC1 expressed in HEK293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presence of DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Kindai University

Curated by ChEMBL
LigandPNGBDBM50460517(CHEMBL4227185)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of recombinant human HDAC1 expressed in HEK293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presence of DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Osaka University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50474910(CHEMBL189836)
Affinity DataIC50:  1.86E+3nMAssay Description:Inhibitory concentration against human DNA topoisomerase IIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50268191(CHEMBL4102765)
Affinity DataIC50:  2.43E+3nMAssay Description:Inhibition of recombinant human DNA topoisomerase-2alpha assessed as decrease in relaxation of supercoiled pBR322 DNA after 30 mins by ethidium bromi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Kindai University

Curated by ChEMBL
LigandPNGBDBM50460524(CHEMBL4225893)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of recombinant human HDAC1 expressed in HEK293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presence of DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Kindai University

Curated by ChEMBL
LigandPNGBDBM50460522(CHEMBL4226829)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of recombinant human HDAC1 expressed in HEK293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presence of DTT by fluorescence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50460517(CHEMBL4227185)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human placenta topoisomerase 2alpha assessed as reduction in pBR322 supercoiled DNA relaxation after 30 mins by ethidium bromide staini...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50268183(CHEMBL4080410)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of recombinant human DNA topoisomerase-2alpha assessed as decrease in relaxation of supercoiled pBR322 DNA after 30 mins by ethidium bromi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Mus musculus)
Kindai University

Curated by ChEMBL
LigandPNGBDBM50268183(CHEMBL4080410)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant mouse HDAC6 expressed in HEK293T cells co-expressing mouse HDA2 using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Kindai University

Curated by ChEMBL
LigandPNGBDBM50268183(CHEMBL4080410)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human HDAC1 expressed in HEK293T cells using Ac-KGLGK(Ac)-MCA as substrate after 30 mins in presence of DTT by fluorescence...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50377927(Clerodol | Fagarasterol | Farganasterol | LUPEOL |...)
Affinity DataIC50:  1.04E+4nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50260250(CHEMBL491188 | Olean-12-en-3beta,15alpha-diol)
Affinity DataIC50:  1.75E+4nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Osaka University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50474907(CHEMBL193251)
Affinity DataIC50:  1.83E+4nMAssay Description:Inhibitory concentration against human DNA topoisomerase IIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50268184(CHEMBL4060026)
Affinity DataIC50:  1.85E+4nMAssay Description:Inhibition of recombinant human DNA topoisomerase-2alpha assessed as decrease in relaxation of supercoiled pBR322 DNA after 30 mins by ethidium bromi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50268183(CHEMBL4080410)
Affinity DataIC50:  1.91E+4nMAssay Description:Inhibition of human placenta topoisomerase 2alpha assessed as reduction in pBR322 supercoiled DNA relaxation after 30 mins by ethidium bromide staini...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Osaka University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50474904(CHEMBL191216)
Affinity DataIC50:  2.27E+4nMAssay Description:Inhibitory concentration against human DNA topoisomerase IIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Osaka University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50474909(CHEMBL189793)
Affinity DataIC50:  2.38E+4nMAssay Description:Inhibitory concentration against human DNA topoisomerase IIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50460525(CHEMBL4228731)
Affinity DataIC50:  2.61E+4nMAssay Description:Inhibition of human placenta topoisomerase 2alpha assessed as reduction in pBR322 supercoiled DNA relaxation after 30 mins by ethidium bromide staini...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50268190(CHEMBL4099888)
Affinity DataIC50:  3.52E+4nMAssay Description:Inhibition of recombinant human DNA topoisomerase-2alpha assessed as decrease in relaxation of supercoiled pBR322 DNA after 30 mins by ethidium bromi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM23207((1R,2R,5S,8R,9R,10R,13R,14R,17S,19R)-5-(hydroxymet...)
Affinity DataIC50:  3.86E+4nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50260252(CHEMBL489552 | olean-12-en-3bea,15alpha,24-triol)
Affinity DataIC50:  3.87E+4nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50250882((23R,25R)-3,4-seco-9beta-H-lanosta-4(28),7-dien-26...)
Affinity DataIC50:  4.26E+4nMAssay Description:Inhibition of human DNA topoisomerase 2alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSensor histidine kinase WalK(Bacillus subtilis (strain 168))
Kinki University

Curated by ChEMBL
LigandPNGBDBM50371212(CHEMBL394220)
Affinity DataIC50:  4.39E+4nMAssay Description:Inhibition of Bacillus subtilis histidine kinase YycGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of human 1 unit topoisomerase 2alpha catalytic activity assessed as relaxation of 198 ng supercoiled pBR322 DNA by agarose gel electrophor...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataIC50:  5.02E+4nMAssay Description:Inhibition of human placenta topoisomerase 2alpha assessed as reduction in pBR322 supercoiled DNA relaxation after 30 mins by ethidium bromide staini...More data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Osaka University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataIC50:  5.04E+4nMAssay Description:Inhibitory concentration against human DNA topoisomerase IIMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50250883((2R,4S,6R)-6-((3R,3aR,5aS,6S,7S,9bR)-6-(3-hydroxyp...)
Affinity DataIC50:  5.04E+4nMAssay Description:Inhibition of human DNA topoisomerase 2alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50460519(CHEMBL4226061)
Affinity DataIC50:  5.53E+4nMAssay Description:Inhibition of human placenta topoisomerase 2alpha assessed as reduction in pBR322 supercoiled DNA relaxation after 30 mins by ethidium bromide staini...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50268187(CHEMBL4104323)
Affinity DataIC50:  5.57E+4nMAssay Description:Inhibition of recombinant human DNA topoisomerase-2alpha assessed as decrease in relaxation of supercoiled pBR322 DNA after 30 mins by ethidium bromi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataIC50:  5.60E+4nMAssay Description:Inhibition of recombinant human DNA topoisomerase-2alpha assessed as decrease in relaxation of supercoiled pBR322 DNA after 30 mins by ethidium bromi...More data for this Ligand-Target Pair
TargetSensor histidine kinase WalK(Bacillus subtilis (strain 168))
Kinki University

Curated by ChEMBL
LigandPNGBDBM50371211(CHEMBL241735)
Affinity DataIC50:  6.35E+4nMAssay Description:Inhibition of Bacillus subtilis histidine kinase YycGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50268185(CHEMBL4088260)
Affinity DataIC50:  6.45E+4nMAssay Description:Inhibition of recombinant human DNA topoisomerase-2alpha assessed as decrease in relaxation of supercoiled pBR322 DNA after 30 mins by ethidium bromi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Osaka University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50474905(CHEMBL426087)
Affinity DataIC50:  6.65E+4nMAssay Description:Inhibitory concentration against human DNA topoisomerase IIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50250884((2R,6R)-methyl 6-((3R,3aR,5aS,6S,7S,9bR)-6-(3-meth...)
Affinity DataIC50:  6.73E+4nMAssay Description:Inhibition of human DNA topoisomerase 2alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50250881(CHEMBL518106 | Methyl (23R,25R)-3,4-seco-9beta-H-l...)
Affinity DataIC50:  7.57E+4nMAssay Description:Inhibition of human DNA topoisomerase 2alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50127140((-)-etoposide | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-d...)
Affinity DataIC50:  7.57E+4nMAssay Description:Inhibition of human DNA topoisomerase 2alphaMore data for this Ligand-Target Pair
TargetDNA topoisomerase 2-alpha/2-beta(Homo sapiens (Human))
Osaka University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50474908(CHEMBL191001)
Affinity DataIC50:  8.32E+4nMAssay Description:Inhibitory concentration against human DNA topoisomerase IIMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50268189(CHEMBL4081883)
Affinity DataIC50:  8.92E+4nMAssay Description:Inhibition of recombinant human DNA topoisomerase-2alpha assessed as decrease in relaxation of supercoiled pBR322 DNA after 30 mins by ethidium bromi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50268172(CHEMBL4061636)
Affinity DataIC50:  9.91E+4nMAssay Description:Inhibition of recombinant human DNA topoisomerase-2alpha assessed as decrease in relaxation of supercoiled pBR322 DNA after 30 mins by ethidium bromi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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