Compile Data Set for Download or QSAR
maximum 50k data
Found 196 with Last Name = 'wagner' and Initial = 'd'
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066770((3R,6S,8aS)-5-Oxo-6-phenylmethanesulfonylamino-hex...)
Affinity DataKi:  111nMAssay Description:Invitro inhibition was measured against Human Thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066766((3R,6R,8aS)-5-Oxo-6-phenylmethanesulfonylamino-hex...)
Affinity DataKi:  145nMAssay Description:Invitro inhibition was measured against Human Thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066769((3R,6R,8aS)-6-(Naphthalene-1-sulfonylamino)-5-oxo-...)
Affinity DataKi:  751nMAssay Description:Invitro inhibition was measured against Human Thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066768((3R,6S,8aS)-6-(Naphthalene-1-sulfonylamino)-5-oxo-...)
Affinity DataKi:  1.45E+3nMAssay Description:Invitro inhibition was measured against Human Thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066769((3R,6R,8aS)-6-(Naphthalene-1-sulfonylamino)-5-oxo-...)
Affinity DataKi:  3.40E+3nMAssay Description:Invitro inhibition was measured against Human bovine pancreatic trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066773((3R,6S,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a...)
Affinity DataKi:  3.58E+3nMAssay Description:Invitro inhibition was measured against Human bovine pancreatic trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066771((3R,6S,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a...)
Affinity DataKi:  5.10E+3nMAssay Description:Invitro inhibition was measured against Human Thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066766((3R,6R,8aS)-5-Oxo-6-phenylmethanesulfonylamino-hex...)
Affinity DataKi:  5.10E+3nMAssay Description:Invitro inhibition was measured against Human bovine pancreatic trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066767((3R,6R,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a...)
Affinity DataKi:  5.36E+3nMAssay Description:Invitro inhibition was measured against Human bovine pancreatic trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066769((3R,6R,8aS)-6-(Naphthalene-1-sulfonylamino)-5-oxo-...)
Affinity DataKi:  6.78E+3nMAssay Description:Invitro inhibition was measured against Human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066770((3R,6S,8aS)-5-Oxo-6-phenylmethanesulfonylamino-hex...)
Affinity DataKi:  7.90E+3nMAssay Description:Invitro inhibition was measured against Human bovine pancreatic trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066772((3R,6R,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a...)
Affinity DataKi:  1.03E+4nMAssay Description:Invitro inhibition was measured against Human Thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066771((3R,6S,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a...)
Affinity DataKi:  1.33E+4nMAssay Description:Invitro inhibition was measured against Human bovine pancreatic trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066768((3R,6S,8aS)-6-(Naphthalene-1-sulfonylamino)-5-oxo-...)
Affinity DataKi:  1.78E+4nMAssay Description:Invitro inhibition was measured against Human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066773((3R,6S,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a...)
Affinity DataKi:  1.95E+4nMAssay Description:Invitro inhibition was measured against Human Thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066768((3R,6S,8aS)-6-(Naphthalene-1-sulfonylamino)-5-oxo-...)
Affinity DataKi:  1.96E+4nMAssay Description:Invitro inhibition was measured against Bovine pancreatic trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066772((3R,6R,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a...)
Affinity DataKi:  2.51E+4nMAssay Description:Invitro inhibition was measured against Human bovine pancreatic trypsin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066766((3R,6R,8aS)-5-Oxo-6-phenylmethanesulfonylamino-hex...)
Affinity DataKi:  2.60E+4nMAssay Description:Invitro inhibition was measured against Human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066771((3R,6S,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a...)
Affinity DataKi: >3.37E+4nMAssay Description:Invitro inhibition was measured against Human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066770((3R,6S,8aS)-5-Oxo-6-phenylmethanesulfonylamino-hex...)
Affinity DataKi: >3.37E+4nMAssay Description:Invitro inhibition was measured against Human Coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Novartis Pharma

Curated by ChEMBL
LigandPNGBDBM50066767((3R,6R,8aS)-6-Amino-5-oxo-hexahydro-thiazolo[3,2-a...)
Affinity DataKi:  6.24E+4nMAssay Description:Invitro inhibition was measured against Human Thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581713(CHEMBL5085027)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of PRMT5 in human HCT116-MTAP null cells assessed as reduction in symmetric dimethylation of arginine using SAM as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581712(CHEMBL5078281)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of PRMT5 in human HCT116-MTAP null cells assessed as reduction in symmetric dimethylation of arginine using SAM as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM27973(6-Ethynylthieno[3,2-d]pyrimidine, 8 | N-{3-chloro-...)
Affinity DataIC50:  7nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287613(1H-Benzotriazole-5-carboxylic acid [(R)-1-((S)-1-c...)
Affinity DataIC50:  8nMAssay Description:Inhibitory activity against human fibroblast collagenase (MMP-1)More data for this Ligand-Target Pair
In DepthDetails Article
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Gsk

LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  9nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Gsk

LigandPNGBDBM27974(5-{2-[4-({3-chloro-4-[(3-fluorophenyl)methoxy]phen...)
Affinity DataIC50:  10nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  11nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287604((R)-N-((S)-1-Carbamoyl-2-phenyl-ethyl)-3-mercapto-...)
Affinity DataIC50:  11nMAssay Description:Compound was tested for its inhibitory activity against 92 kD gelatinase (MMP-9)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287599(1H-Benzotriazole-5-carboxylic acid [(R)-1-((S)-1-c...)
Affinity DataIC50:  12nMAssay Description:Inhibitory activity against human fibroblast collagenase (MMP-1)More data for this Ligand-Target Pair
In DepthDetails Article
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Gsk

LigandPNGBDBM27971(6-Ethynylthieno[3,2-d]pyrimidine, 6 | N-{3-chloro-...)
Affinity DataIC50:  12nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Gsk

LigandPNGBDBM27973(6-Ethynylthieno[3,2-d]pyrimidine, 8 | N-{3-chloro-...)
Affinity DataIC50:  13nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581712(CHEMBL5078281)
Affinity DataIC50:  13nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287602(CHEMBL57056 | N-[(R)-1-((S)-1-Carbamoyl-2-phenyl-e...)
Affinity DataIC50:  15nMAssay Description:Compound was tested for its inhibitory activity against 92 kD gelatinase (MMP-9)More data for this Ligand-Target Pair
In DepthDetails Article
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581709(CHEMBL5075691)
Affinity DataIC50:  16nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581711(CHEMBL5078692)
Affinity DataIC50:  17nMAssay Description:Inhibition of PRMT5 in human HCT116-MTAP null cells assessed as reduction in symmetric dimethylation of arginine using SAM as substrate incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581713(CHEMBL5085027)
Affinity DataIC50:  18nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287609(Benzo[1,3]dioxole-5-carboxylic acid [(R)-1-((S)-1-...)
Affinity DataIC50:  19nMAssay Description:Compound was tested for its inhibitory activity against 92 kD gelatinase (MMP-9)More data for this Ligand-Target Pair
In DepthDetails Article
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Gsk

LigandPNGBDBM27975(6-Ethynylthieno[2,3-d]pyrimidine, 10 | N-{3-chloro...)
Affinity DataIC50:  19nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287617(Biphenyl-4-carboxylic acid [(R)-1-((S)-1-carbamoyl...)
Affinity DataIC50:  21nMAssay Description:Compound was tested for its inhibitory activity against 92 kD gelatinase (MMP-9)More data for this Ligand-Target Pair
In DepthDetails Article
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50581711(CHEMBL5078692)
Affinity DataIC50:  21nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetS-adenosylmethionine synthase isoform type-2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM507762(7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(...)
Affinity DataIC50:  22nMAssay Description:Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubate...More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287613(1H-Benzotriazole-5-carboxylic acid [(R)-1-((S)-1-c...)
Affinity DataIC50:  24nMAssay Description:Compound was tested for its inhibitory activity against 92 kD gelatinase (MMP-9)More data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gsk

LigandPNGBDBM27971(6-Ethynylthieno[3,2-d]pyrimidine, 6 | N-{3-chloro-...)
Affinity DataIC50:  24nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM507762(7-chloro-4-(dimethylamino)-1-phenyl- quinazolin-2(...)
Affinity DataIC50:  25nMAssay Description:Inhibition of PRMT5 in human HCT116-MTAP null cells assessed as reduction in symmetric dimethylation of arginine using SAM as substrate incubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287598(1H-Pyrazole-4-carboxylic acid [(R)-1-((S)-1-carbam...)
Affinity DataIC50:  26nMAssay Description:Inhibitory activity against human fibroblast collagenase (MMP-1)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287611(1H-Pyrazole-4-carboxylic acid [(R)-1-((S)-1-carbam...)
Affinity DataIC50:  26nMAssay Description:Inhibitory activity against human fibroblast collagenase (MMP-1)More data for this Ligand-Target Pair
In DepthDetails Article
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Gsk

LigandPNGBDBM27972(6-Ethynylthieno[3,2-d]pyrimidine, 7 | 6-[(3S)-3-am...)
Affinity DataIC50:  27nMpH: 7.5 T: 2°CAssay Description:Assays were performed in 96-well microtiter plates in reaction buffer containing biotinylated substrate, ATP/[gamma-33P]ATP, and purified kinase in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287600((S)-2-[(R)-3-Mercapto-2-(2-phenoxy-acetylamino)-pr...)
Affinity DataIC50:  34nMAssay Description:Compound was tested for its inhibitory activity against 92 kD gelatinase (MMP-9)More data for this Ligand-Target Pair
In DepthDetails Article
TargetInterstitial collagenase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50287596(1H-Benzotriazole-5-carboxylic acid [(R)-1-((S)-1-c...)
Affinity DataIC50:  34nMAssay Description:Inhibitory activity against human fibroblast collagenase (MMP-1)More data for this Ligand-Target Pair
In DepthDetails Article
Displayed 1 to 50 (of 196 total ) | Next | Last >>
Jump to: