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Found 16 with Last Name = 'wakai' and Initial = 'h'
TargetSerine/threonine-protein kinase WNK1 [166-489](Homo sapiens (Human))
Novartis Institutes

LigandPNGBDBM203827(N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...)
Affinity DataIC50:  1nMpH: 7.3 T: 2°CAssay Description:Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase WNK1 [1-491](Homo sapiens (Human))
Novartis Institutes

LigandPNGBDBM203827(N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...)
Affinity DataIC50:  5nMpH: 7.3 T: 2°CAssay Description:Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase WNK1 [1-434](Homo sapiens (Human))
Novartis Institutes

LigandPNGBDBM203827(N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...)
Affinity DataIC50:  6nMpH: 7.3 T: 2°CAssay Description:Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase WNK1 [1-444](Homo sapiens (Human))
Novartis Institutes

LigandPNGBDBM203827(N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...)
Affinity DataIC50:  9nMpH: 7.3 T: 2°CAssay Description:Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase WNK1 [1-491](Homo sapiens (Human))
Novartis Institutes

LigandPNGBDBM203827(N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...)
Affinity DataIC50:  41nMpH: 7.3 T: 2°CAssay Description:Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase WNK2 [166-489](Homo sapiens (Human))
Novartis Institutes For Biomedical Research

LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50:  50nMpH: 7.3Assay Description:The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase WNK1 [1-491](Homo sapiens (Human))
Novartis Institutes

LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50:  64nMpH: 7.3Assay Description:The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase WNK1 [1-491](Homo sapiens (Human))
Novartis Institutes

LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50:  150nMpH: 7.5Assay Description:A mixture of fluorescein labeled OSR1 peptide substrate (Toray Research Center, Inc.) and ATP was prepared with final concentrations of 10 and 25 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase WNK1 [1-491](Homo sapiens (Human))
Novartis Institutes

LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50:  180nMpH: 7.5Assay Description:A mixture of fluorescein labeled OSR1 peptide substrate (Toray Research Center, Inc.) and ATP was prepared with final concentrations of 10 and 25 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase WNK4 [1-444](Homo sapiens (Human))
Novartis Institutes For Biomedical Research

LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50:  187nMpH: 7.3Assay Description:The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase WNK3 [1-434](Homo sapiens (Human))
Novartis Institutes For Biomedical Research

LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50:  377nMpH: 7.3Assay Description:The assay utilized 5 to 10 nM of WNK1−4 protein compared to 25 nM used for mobility shift assay, enabling a more accurate comparison of selecti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSerine/threonine-protein kinase WNK1 [1-491](Homo sapiens (Human))
Novartis Institutes

LigandPNGBDBM203826((R)-1-(1-(2-(4-methoxyphenyl)acetyl)pyrrolidin-3-y...)
Affinity DataIC50:  856nMpH: 7.3 T: 2°CAssay Description:Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase WNK1 [198-401](Homo sapiens (Human))
Novartis Institutes For Biomedical Research

LigandPNGBDBM49829((2-fluorophenyl)(5-(2-(methylamino)thiazol-4-yl)in...)
Affinity DataIC50:  5.70E+3nMAssay Description:For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 &#...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase WNK1 [198-401](Homo sapiens (Human))
Novartis Institutes For Biomedical Research

LigandPNGBDBM49829((2-fluorophenyl)(5-(2-(methylamino)thiazol-4-yl)in...)
Affinity DataIC50:  8.80E+3nMAssay Description:For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 &#...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase WNK1 [198-401](Homo sapiens (Human))
Novartis Institutes For Biomedical Research

LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50:  1.60E+4nMAssay Description:For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 &#...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase WNK1 [198-401](Homo sapiens (Human))
Novartis Institutes For Biomedical Research

LigandPNGBDBM207990((2-((4-Chlorobenzyl)oxy)phenyl)(5-(2-(methylamino)...)
Affinity DataIC50: >8.00E+4nMAssay Description:For hit validation, eight compound replicates were made from the original stock dilution plates. The Cybi-WellTM dispenser was used to prepare 1.5 &#...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed