Affinity DataKi: 0.0900nMAssay Description:Inhibition of recombinant human cathepsin S using Z-VVR-AMC as substrate preincubated for 15 mins followed by substrate addition and measured after 1...More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Inhibition of catalytic activity of rat COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liquid scint...More data for this Ligand-Target Pair
Affinity DataKi: 1.5nMAssay Description:Inhibition of catalytic activity of mouse COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liquid sci...More data for this Ligand-Target Pair
Affinity DataKi: 6.30E+3nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair
Affinity DataKi: 7.90E+3nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair
Affinity DataKi: 2.50E+4nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair
Affinity DataKi: 6.30E+4nMAssay Description:Inhibition of catalytic activity of mouse COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liquid sci...More data for this Ligand-Target Pair
Affinity DataKi: 1.58E+5nMAssay Description:Inhibition of catalytic activity of rat COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liquid scint...More data for this Ligand-Target Pair
Affinity DataKi: 2.51E+5nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair
Affinity DataIC50: 0.100nMAssay Description:Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFKC as substrate measured by TR-FRET assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal GST-tagged human JAK1 (850 to 1154 residues) expressed in baculovirus expression system using TK-substrate-biotin as substra...More data for this Ligand-Target Pair
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of Escherichia coli DNA gyrase by isothermal titration calorimetry (ITC) assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibition of N-terminal 6His-tagged human BRD4 BD1 (49 to 170 residues) expressed in Escherichia coli BL21 (DE3) using biotin-labeled H4 peptide as ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Paradigm Therapeutics
Curated by ChEMBL
Paradigm Therapeutics
Curated by ChEMBL
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Paradigm Therapeutics
Curated by ChEMBL
Paradigm Therapeutics
Curated by ChEMBL
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Paradigm Therapeutics
Curated by ChEMBL
Paradigm Therapeutics
Curated by ChEMBL
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataIC50: 9.80nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human Lp-PLA2 using 2-thio-PAF as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human PKCzeta using biotin-KKKKRFSFKKSFKC as substrate measured by TR-FRET assayMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of human MNK1 measured by Caliper-based biochemical assayMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of human MNK2 measured by Caliper-based biochemical assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human ALK (1058 to 1620 residues) expressed in baculovirus expression system using poly-(GT)-biotin as substrate preincubat...More data for this Ligand-Target Pair
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of human Notum (S81 to T451 residues) Cys330Ser mutant expressed in HEK293S cells using OPTS as substrate incubated for 40 mins by fluores...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Negative allosteric modulation activity at NPBWR1 (unknown origin)More data for this Ligand-Target Pair
TargetFatty acid-binding protein, adipocyte(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of FABP4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of mouse recombinant sPLA2 G2AMore data for this Ligand-Target Pair
TargetGroup IIE secretory phospholipase A2(Homo sapiens (Human))
University Of Washington
Curated by ChEMBL
University Of Washington
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant sPLA2 G2EMore data for this Ligand-Target Pair
TargetGroup IIE secretory phospholipase A2(Homo sapiens (Human))
University Of Washington
Curated by ChEMBL
University Of Washington
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant sPLA2 G2EMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of mouse recombinant sPLA2 G2AMore data for this Ligand-Target Pair
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
University Of Washington
Curated by ChEMBL
University Of Washington
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of mouse recombinant sPLA2 G2AMore data for this Ligand-Target Pair
TargetGroup 10 secretory phospholipase A2(Homo sapiens (Human))
University Of Washington
Curated by ChEMBL
University Of Washington
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibition of human recombinant sPLA2 G10More data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Inhibition of mouse recombinant sPLA2 G10More data for this Ligand-Target Pair
TargetGroup 10 secretory phospholipase A2(Homo sapiens (Human))
University Of Washington
Curated by ChEMBL
University Of Washington
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibition of human recombinant sPLA2 G10More data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Inhibition of mouse recombinant sPLA2 G2EMore data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Inhibition of mouse recombinant sPLA2 G10More data for this Ligand-Target Pair
TargetGroup IIE secretory phospholipase A2(Homo sapiens (Human))
University Of Washington
Curated by ChEMBL
University Of Washington
Curated by ChEMBL
Affinity DataIC50: 75nMAssay Description:Inhibition of human recombinant sPLA2 G2EMore data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Inhibition of mouse recombinant sPLA2 G2EMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of JAK1 in human STAT6-bla RA-1 cells assessed as reduction in IL-4 induced STAT6 phosphorylation preincubated for 1 hr followed by IL-4 a...More data for this Ligand-Target Pair
TargetPalmitoleoyl-protein carboxylesterase NOTUM(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of human Notum (S81 to T451 residues) Cys330Ser mutant expressed in HEK293S cells using OPTS as substrate incubated for 40 mins by fluores...More data for this Ligand-Target Pair
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
University Of Washington
Curated by ChEMBL
University Of Washington
Curated by ChEMBL
Affinity DataIC50: 125nMAssay Description:Inhibition of human recombinant sPLA2 G2AMore data for this Ligand-Target Pair
TargetGroup IIE secretory phospholipase A2(Homo sapiens (Human))
University Of Washington
Curated by ChEMBL
University Of Washington
Curated by ChEMBL
Affinity DataIC50: 125nMAssay Description:Inhibition of human recombinant sPLA2 G2EMore data for this Ligand-Target Pair
Affinity DataIC50: 125nMAssay Description:Inhibition of mouse recombinant sPLA2 G2AMore data for this Ligand-Target Pair
Affinity DataIC50: 125nMAssay Description:Inhibition of mouse recombinant sPLA2 G2AMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of mouse recombinant sPLA2 G1BMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of mouse recombinant sPLA2 G1BMore data for this Ligand-Target Pair
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
University Of Washington
Curated by ChEMBL
University Of Washington
Curated by ChEMBL
Affinity DataIC50: 275nMAssay Description:Inhibition of human recombinant sPLA2 G2AMore data for this Ligand-Target Pair
TargetPhospholipase A2, membrane associated(Homo sapiens (Human))
University Of Washington
Curated by ChEMBL
University Of Washington
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant sPLA2 G2AMore data for this Ligand-Target Pair
TargetEnoyl-[acyl-carrier-protein] reductase [NADH](Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Inhibition of recombinant hexaHis-SUMO tagged Mycobacterium tuberculosis InhA expressed in Escherichia coli BL21 (DE3) incubated for 10 mins by color...More data for this Ligand-Target Pair
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Vrije Universiteit Amsterdam
Curated by ChEMBL
Vrije Universiteit Amsterdam
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of full-length human sEH (1 to 555 residues) expressed in Escherichia coli BL21 (DE3) using PHOME as substrate preincubated for 45 mins fo...More data for this Ligand-Target Pair