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Found 519 with Last Name = 'warne' and Initial = 'r'
TargetTryptase beta-2(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50084616(CHEMBL310290 | [(4-Aminomethyl-benzylcarbamoyl)-me...)
Affinity DataKi:  0.600nMAssay Description:Inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50003154(2-{Propyl-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataKi:  0.760nMAssay Description:Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM85050(CAS_184162-64-9 | SR 142948A | SR142948 | SR142948...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125I]neurotensin from rat NTS1 receptor expressed in CHO-K1 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM85050(CAS_184162-64-9 | SR 142948A | SR142948 | SR142948...)
Affinity DataKi:  2nMAssay Description:Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093132(CHEMBL75749 | [3-(4-Guanidino-benzyl)-ureido]-acet...)
Affinity DataKi:  2nMAssay Description:Inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50063920((R)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propy...)
Affinity DataKi:  2nMAssay Description:Inhibition of Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50063920((R)-N*1*-((S)-2,2-Dimethyl-1-methylcarbamoyl-propy...)
Affinity DataKi:  2nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50003158(2-Methyl-4-{propyl-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Affinity DataKi:  2.80nMAssay Description:Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093143(CHEMBL76733 | N-(4-Aminomethyl-benzyl)-N'-(4-{[3-(...)
Affinity DataKi:  3nMAssay Description:Inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50003155(4-{Butyl-[2''-(2H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataKi:  3.10nMAssay Description:Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093133(CHEMBL79822 | N-(4-Aminomethyl-benzyl)-N'-[4-({[3-...)
Affinity DataKi:  5nMAssay Description:Inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093131(CHEMBL80210 | [(4-Aminomethyl-benzylcarbamoyl)-met...)
Affinity DataKi:  5nMAssay Description:Inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 2(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM85050(CAS_184162-64-9 | SR 142948A | SR142948 | SR142948...)
Affinity DataKi:  5.80nMAssay Description:Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 2(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM85050(CAS_184162-64-9 | SR 142948A | SR142948 | SR142948...)
Affinity DataKi:  6nMAssay Description:Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 2(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM85050(CAS_184162-64-9 | SR 142948A | SR142948 | SR142948...)
Affinity DataKi:  7nMAssay Description:Displacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093141(CHEMBL306537 | Pentanedioic acid 4-aminomethyl-ben...)
Affinity DataKi:  9nMAssay Description:Inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093135(CHEMBL77911 | [(4-Guanidino-benzylcarbamoyl)-methy...)
Affinity DataKi:  10nMAssay Description:Inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103099((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  11nMAssay Description:Inhibitionof Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50003156(4-{Butyl-[2''-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...)
Affinity DataKi:  15nMAssay Description:Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor B(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM82258(CAS_114798-26-4 | Losartan | NSC_3961)
Affinity DataKi:  15nMAssay Description:Compound was evaluated for binding affinity against angiotensin II receptor, type 1 in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103097((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  16nMAssay Description:Inhibition of Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103097((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  16nMAssay Description:Inhibitionof Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103102((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  17nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103096((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  17nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103092((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  17nMAssay Description:Inhibition of Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 2(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  19nMAssay Description:Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103093((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  20nMAssay Description:Inhibitionof Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103098((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  20nMAssay Description:Inhibitionof Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 2(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  21nMAssay Description:Displacement of [125L]NT from rat neurotensin receptor type 2 expressed in CHOK1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103092((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  21nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103099((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  24nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50041427(CHEMBL3356853)
Affinity DataKi: >25nMAssay Description:Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50041428(CHEMBL3356855)
Affinity DataKi: >25nMAssay Description:Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 1(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50041429(CHEMBL3356854)
Affinity DataKi: >25nMAssay Description:Displacement of [125L]NT from rat neurotensin receptor type 1 expressed in CHOK1 cells by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103098((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  27nMAssay Description:Inhibition of Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103102((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  27nMAssay Description:Inhibitionof Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 2(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50130880(CHEMBL407196 | NT(1-13) | neurotensin | pGlu-Leu-T...)
Affinity DataKi:  28nMAssay Description:Displacement of [125I]neurotensin from rat NTS2 receptor expressed in CHO-K1 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103097((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  28nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103093((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  29nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103095((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  29nMAssay Description:Inhibitionof Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093139(CHEMBL310289 | [(R)-1-(4-Aminomethyl-benzylcarbamo...)
Affinity DataKi:  31nMAssay Description:Inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103101((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  31nMAssay Description:Inhibitionof Tumor necrosis factor alpha converting enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 2(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50240845((S)-2-{(2S,3R)-2-[(S)-2-({(S)-1-[(S)-2-((S)-2-Amin...)
Affinity DataKi:  33nMAssay Description:Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103100((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  33nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurotensin receptor type 2(Rattus norvegicus)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50019405(LEVOCABASTINE | R-50547)
Affinity DataKi:  33nMAssay Description:Displacement of [125I]NT at rat NTS2 overexpressed in CHOK1 cells after 30 mins by gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103098((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  34nMAssay Description:Inhibition of Matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103102((R)-2-[(S)-1-(Formyl-hydroxy-amino)-ethyl]-4-methy...)
Affinity DataKi:  36nMAssay Description:Inhibition of Matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50103101((2R,3S)-3-(Formyl-hydroxy-amino)-2-isobutyl-pentan...)
Affinity DataKi:  38nMAssay Description:Inhibition of matrix metalloprotease-3 (MMP3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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