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Found 327 with Last Name = 'watanabe' and Initial = 's'
LigandPNGBDBM50058752(CHEMBL3335630)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036542(CHEMBL3353600)
Affinity DataIC50:  0.960nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058757(CHEMBL3335423)
Affinity DataIC50:  0.970nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058753(CHEMBL3335427)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058754(CHEMBL3335426)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058760(CHEMBL3335421)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058766(CHEMBL3335415)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036544(CHEMBL3353601)
Affinity DataIC50:  3.30nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Toho University

Curated by ChEMBL
LigandPNGBDBM50559528(CHEMBL3950588)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptakeMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Toho University

Curated by ChEMBL
LigandPNGBDBM50559538(CHEMBL3908950)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptakeMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220573(1-(1-(3-chloro-4-hydroxyphenyl)-1-hydroxypropan-2-...)
Affinity DataIC50:  5.60nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058755(CHEMBL3335425)
Affinity DataIC50:  5.80nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036517(CHEMBL3353597)
Affinity DataIC50:  5.80nMAssay Description:Antagonist activity at rat TRPM8 assessed as inhibition of menthol induced Ca2+ influx by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036555(CHEMBL3353610 | US9434711, 497)
Affinity DataIC50:  6.20nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220589(6-(1-hydroxy-2-(4-hydroxy-4-(3-(phenoxymethyl)phen...)
Affinity DataIC50:  6.30nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220583(6-(2-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-...)
Affinity DataIC50:  6.60nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220586(1-[2-hydroxy-2-(6-hydroxy-biphenyl-3-yl)-1-methyl-...)
Affinity DataIC50:  6.80nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058762(CHEMBL3335419)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058770(CHEMBL3335411)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036545(CHEMBL3353602)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036517(CHEMBL3353597)
Affinity DataIC50:  8.30nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220588(6-(1-hydroxy-2-(4-hydroxy-4-(3-methoxyphenyl)piper...)
Affinity DataIC50:  8.30nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220581(7-(2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)
Affinity DataIC50:  8.70nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Toho University

Curated by ChEMBL
LigandPNGBDBM50559527(CHEMBL3907970)
Affinity DataIC50:  8.80nMAssay Description:Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptakeMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036537(CHEMBL3353594)
Affinity DataIC50:  8.90nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036554(CHEMBL3353609)
Affinity DataIC50:  9nMAssay Description:Antagonist activity at rat TRPM8 assessed as inhibition of menthol induced Ca2+ influx by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50025312(2-(3,4-Dihydroxy-phenyl)-5-hydroxy-7-methoxy-6-(3-...)
Affinity DataIC50:  9nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220574(6-(1-hydroxy-2-(4-hydroxy-4-p-tolylpiperidin-1-yl)...)
Affinity DataIC50:  9.10nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220584(6-(2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)
Affinity DataIC50:  9.10nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Toho University

Curated by ChEMBL
LigandPNGBDBM50559522(CHEMBL3960449)
Affinity DataIC50:  10nMAssay Description:Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptakeMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220577(6-(2-(4-(3-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)
Affinity DataIC50:  10nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Toho University

Curated by ChEMBL
LigandPNGBDBM50559524(CHEMBL3923809)
Affinity DataIC50:  11nMAssay Description:Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptakeMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220576(6-(2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50025315(2-(3,4-Dihydroxy-phenyl)-5-hydroxy-7-methoxy-6-oct...)
Affinity DataIC50:  11nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50025322(6-Decyloxy-2-(3,4-dihydroxy-phenyl)-5-hydroxy-7-me...)
Affinity DataIC50:  11nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036554(CHEMBL3353609)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Toho University

Curated by ChEMBL
LigandPNGBDBM50559525(CHEMBL3934976)
Affinity DataIC50:  12nMAssay Description:Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptakeMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Toho University

Curated by ChEMBL
LigandPNGBDBM50559529(CHEMBL3896936)
Affinity DataIC50:  12nMAssay Description:Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptakeMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50058771(CHEMBL3335410)
Affinity DataIC50:  13nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058765(CHEMBL3335416)
Affinity DataIC50:  13nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50032651(1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-y...)
Affinity DataIC50:  14nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036541(CHEMBL3353599)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058768(CHEMBL3335413)
Affinity DataIC50:  14nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220582(6-(2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)
Affinity DataIC50:  14nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50025291(2-(3,4-Dihydroxy-phenyl)-6-hexyloxy-5,7-dimethoxy-...)
Affinity DataIC50:  14nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50025278(6-Butoxy-2-(3,4-dihydroxy-phenyl)-5-hydroxy-7-meth...)
Affinity DataIC50:  15nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50220578(6-(2-(4-(3,4-dihydro-1H-isochromen-7-yl)-4-hydroxy...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma

Curated by ChEMBL
LigandPNGBDBM50036551(CHEMBL3353606)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50025286(2-(3,4-Dihydroxy-phenyl)-5-hexyloxy-6,7-dimethoxy-...)
Affinity DataIC50:  15nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Toho University

Curated by ChEMBL
LigandPNGBDBM50559523(CHEMBL3915296)
Affinity DataIC50:  15nMAssay Description:Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptakeMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
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