TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Eisai
Curated by ChEMBL
Eisai
Curated by ChEMBL
Affinity DataIC50: 0.470nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma
Curated by ChEMBL
Raqualia Pharma
Curated by ChEMBL
Affinity DataIC50: 0.960nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Eisai
Curated by ChEMBL
Eisai
Curated by ChEMBL
Affinity DataIC50: 0.970nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Eisai
Curated by ChEMBL
Eisai
Curated by ChEMBL
Affinity DataIC50: 1.10nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Eisai
Curated by ChEMBL
Eisai
Curated by ChEMBL
Affinity DataIC50: 2.60nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Eisai
Curated by ChEMBL
Eisai
Curated by ChEMBL
Affinity DataIC50: 3.10nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Eisai
Curated by ChEMBL
Eisai
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma
Curated by ChEMBL
Raqualia Pharma
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Eisai
Curated by ChEMBL
Eisai
Curated by ChEMBL
Affinity DataIC50: 5.80nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
Raqualia Pharma
Curated by ChEMBL
Raqualia Pharma
Curated by ChEMBL
Affinity DataIC50: 5.80nMAssay Description:Antagonist activity at rat TRPM8 assessed as inhibition of menthol induced Ca2+ influx by cell-based assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma
Curated by ChEMBL
Raqualia Pharma
Curated by ChEMBL
Affinity DataIC50: 6.20nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
Affinity DataIC50: 6.30nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 6.60nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 6.80nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Eisai
Curated by ChEMBL
Eisai
Curated by ChEMBL
Affinity DataIC50: 7.90nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Eisai
Curated by ChEMBL
Eisai
Curated by ChEMBL
Affinity DataIC50: 7.90nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma
Curated by ChEMBL
Raqualia Pharma
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma
Curated by ChEMBL
Raqualia Pharma
Curated by ChEMBL
Affinity DataIC50: 8.30nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
Affinity DataIC50: 8.30nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 8.70nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 8.80nMAssay Description:Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptakeMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma
Curated by ChEMBL
Raqualia Pharma
Curated by ChEMBL
Affinity DataIC50: 8.90nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Rattus norvegicus (Rat))
Raqualia Pharma
Curated by ChEMBL
Raqualia Pharma
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Antagonist activity at rat TRPM8 assessed as inhibition of menthol induced Ca2+ influx by cell-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
Affinity DataIC50: 9.10nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 9.10nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma
Curated by ChEMBL
Raqualia Pharma
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptakeMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptakeMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Eisai
Curated by ChEMBL
Eisai
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Eisai
Curated by ChEMBL
Eisai
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma
Curated by ChEMBL
Raqualia Pharma
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Eisai
Curated by ChEMBL
Eisai
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membraneMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily M member 8(Homo sapiens (Human))
Raqualia Pharma
Curated by ChEMBL
Raqualia Pharma
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influxMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells.More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptakeMore data for this Ligand-Target Pair