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Found 1063 with Last Name = 'watt' and Initial = 'ap'
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082406(1-(2-fluorophenoxy)-3-spiro[1,3-dihydrobenzo[e]iso...)
Affinity DataKi:  1nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082405(1-phenoxy-3-spiro[1,3-dihydrobenzo[e]isobenzofuran...)
Affinity DataKi:  1.10nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082413(1-(3-ethylphenoxy)-3-spiro[1,3-dihydrobenzo[e]isob...)
Affinity DataKi:  1.70nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082408(1-benzyloxy-3-spiro[1,3-dihydrobenzo[e]isobenzofur...)
Affinity DataKi:  2.20nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082410(4-fluoro-7-[2-hydroxy-3-spiro[1,3-dihydrobenzo[e]i...)
Affinity DataKi:  2.30nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082411(1-(5-fluoro-3,4-dihydro-2H-8-chromenyloxy)-3-spiro...)
Affinity DataKi:  2.80nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082407(1-(6-fluoro-3,4-dihydro-2H-8-chromenyloxy)-3-spiro...)
Affinity DataKi:  5.5nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082415(1-(2-fluorophenoxy)-3-spiro[1,3-dihydrobenzo[e]iso...)
Affinity DataKi:  6nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082412(1-phenyl-3-spiro[1,3-dihydrobenzo[e]isobenzofuran-...)
Affinity DataKi:  8.30nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082412(1-phenyl-3-spiro[1,3-dihydrobenzo[e]isobenzofuran-...)
Affinity DataKi:  10nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50019443(1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol ...)
Affinity DataKi:  24nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082414(1'-(4-phenylbutyl)spiro[1,3-dihydrobenzo[e]isobenz...)
Affinity DataKi:  28nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082410(4-fluoro-7-[2-hydroxy-3-spiro[1,3-dihydrobenzo[e]i...)
Affinity DataKi:  45nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082411(1-(5-fluoro-3,4-dihydro-2H-8-chromenyloxy)-3-spiro...)
Affinity DataKi:  49nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082405(1-phenoxy-3-spiro[1,3-dihydrobenzo[e]isobenzofuran...)
Affinity DataKi:  50nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082406(1-(2-fluorophenoxy)-3-spiro[1,3-dihydrobenzo[e]iso...)
Affinity DataKi:  52nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50082414(1'-(4-phenylbutyl)spiro[1,3-dihydrobenzo[e]isobenz...)
Affinity DataKi:  72nMAssay Description:Displacement of specific [3H]- 5-HT binding to cloned human 5-hydroxytryptamine 1A receptor stably expressed in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082407(1-(6-fluoro-3,4-dihydro-2H-8-chromenyloxy)-3-spiro...)
Affinity DataKi:  72nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082408(1-benzyloxy-3-spiro[1,3-dihydrobenzo[e]isobenzofur...)
Affinity DataKi:  83nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082413(1-(3-ethylphenoxy)-3-spiro[1,3-dihydrobenzo[e]isob...)
Affinity DataKi:  87nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50082415(1-(2-fluorophenoxy)-3-spiro[1,3-dihydrobenzo[e]iso...)
Affinity DataKi:  120nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM50019443(1-(1H-Indol-4-yloxy)-3-isopropylamino-propan-2-ol ...)
Affinity DataKi: >7.00E+3nMAssay Description:Displacement of specific [3H]- citalopram binding to 5-HT uptake site in rat whole cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50052278(5-[(2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2...)
Affinity DataIC50:  0.0500nMAssay Description:Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50454480(CHEMBL2093059)
Affinity DataIC50:  0.0540nMAssay Description:Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50454481(CHEMBL2110201)
Affinity DataIC50:  0.0740nMAssay Description:Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290861(5-{3-[1-(3,5-Dichloro-phenyl)-ethoxy]-2-phenyl-pip...)
Affinity DataIC50:  0.0900nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In DepthDetails Article
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077807(3-{3-[4-Fluoro-4-(2-fluoro-benzyl)-piperidin-1-yl]...)
Affinity DataIC50:  0.100nMAssay Description:Displacement of specific [3H]-5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50059319(1-[(R)-5-(3-Aza-bicyclo[3.2.2]non-3-yl)-1-methyl-2...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of ligand binding to Cholecystokinin type B receptor from guinea pig cortical membrane.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50074186(3-{3-[4-(4-Fluoro-benzyl)-piperazin-1-yl]-propyl}-...)
Affinity DataIC50:  0.100nMAssay Description:Displacement of [3H]-5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060440(3-[3-(4-Benzyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataIC50:  0.100nMAssay Description:Displacement of [3H]-5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50040667(1-[(R)-5-(3-Aza-bicyclo[3.2.2]non-3-yl)-1-methyl-2...)
Affinity DataIC50:  0.100nMAssay Description:Binding activity against Cholecystokinin type B receptor from guinea pig cortex using [125]BH CCK-8s as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50049783(1-((R)-1-Methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benz...)
Affinity DataIC50:  0.110nMAssay Description:Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50106774(2-(4-{3-[5-Chloro-2-(4-chloro-phenyl)-1-methyl-1H-...)
Affinity DataIC50:  0.130nMAssay Description:Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060440(3-[3-(4-Benzyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataIC50:  0.140nMAssay Description:Displacement of specific [3H]-5-HT binding to cloned human 5-hydroxytryptamine 1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290865(3-[1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2-ph...)
Affinity DataIC50:  0.150nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099511(1-(4-Benzyl-4-hydroxy-piperidin-1-yl)-3-[5-chloro-...)
Affinity DataIC50:  0.150nMAssay Description:Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099516(1-(4-Benzyl-4-hydroxy-piperidin-1-yl)-3-[5-chloro-...)
Affinity DataIC50:  0.160nMAssay Description:Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290859(5-{3-[1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2...)
Affinity DataIC50:  0.160nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50290856(3-[1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-2-ph...)
Affinity DataIC50:  0.160nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50106771(CHEMBL319046 | N-(1-{3-[5-Chloro-2-(4-chloro-pheny...)
Affinity DataIC50:  0.160nMAssay Description:Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50052280((2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-ph...)
Affinity DataIC50:  0.180nMAssay Description:Antagonism of NK1 receptor in rat liver microsomes.More data for this Ligand-Target Pair
In DepthDetails Article
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099514(3-[5-Acetyl-2-(4-chloro-phenyl)-1-methyl-1H-indol-...)
Affinity DataIC50:  0.190nMAssay Description:Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060440(3-[3-(4-Benzyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50074188(2-Phenyl-2-{4-[3-(5-[1,2,4]triazol-4-yl-1H-indol-3...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]-5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50074205(CHEMBL161176 | N-(3-{4-[3-(5-[1,2,4]Triazol-4-yl-1...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]-5-HT binding to the cloned human 5-hydroxytryptamine 1D receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Neuroscience Research Centre

Curated by ChEMBL
LigandPNGBDBM50049789(1-((R)-5-Cyclohexyl-1-methyl-2-oxo-2,3-dihydro-1H-...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of [125 I]BH CCK-8S binding to Cholecystokinin type B receptor in guinea pig cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060440(3-[3-(4-Benzyl-piperazin-1-yl)-propyl]-5-[1,2,4]tr...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099516(1-(4-Benzyl-4-hydroxy-piperidin-1-yl)-3-[5-chloro-...)
Affinity DataIC50:  0.210nMAssay Description:Ability to displace [125I]-labeled substance P from human cloned Tachykinin receptor 1 in CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50052280((2S,3S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-2-ph...)
Affinity DataIC50:  0.220nMAssay Description:Displacement of [125 I]-Tyr8 SP from the cloned human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50099528(1-(4-Benzyl-4-hydroxy-piperidin-1-yl)-3-[5-bromo-2...)
Affinity DataIC50:  0.220nMAssay Description:Concentration required for displacement of [125I]-labeled substance P from cloned hNK1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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