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Found 264 with Last Name = 'werth' and Initial = 'r'
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50331002(CHEMBL1277801 | [5-(3-Chloro-4-hydroxyphenyl)-2-th...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human placenta 17beta-HSD1 using [2,4,6,7-3H]-estrone as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50330998((5-(2-fluoro-3-hydroxyphenyl)thiophen-2-yl)(3-hydr...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human placenta 17beta-HSD1 using [2,4,6,7-3H]-estrone as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50330999(CHEMBL1277708 | [5-(4-Hydroxy-3-methylphenyl)-2-th...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human placenta 17beta-HSD1 using [2,4,6,7-3H]-estrone as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50299643(2-Fluoro-4-[5-(3-hydroxyphenyl)-2-thienyl]phenol |...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human placental 17betaHSD1 by radiodetection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335818(6-(3-Hydroxyphenyl)-1-(pyridin-3-yl)-2-naphthol | ...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50121975((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335815(CHEMBL1650658 | N-{3-[2-Hydroxy-6-(3-hydroxyphenyl...)
Affinity DataIC50:  15nMAssay Description:Displacement of [3H]E1 from human placental 17beta-HSD1 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50331001((5-(4-hydroxy-3-(trifluoromethyl)phenyl)thiophen-2...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human placenta 17beta-HSD1 using [2,4,6,7-3H]-estrone as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50299656(2-Fluoro-4-[5-(4-fluoro-3-hydroxyphenyl)thien-2-yl...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human placental 17betaHSD1 by radiodetection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50331000(CHEMBL1277709 | [5-(3-Fluoro-4-hydroxyphenyl)-2-th...)
Affinity DataIC50:  17nMAssay Description:Inhibition of 17beta-HSD1 in human T47D cells using [2,4,6,7-3H]-estrone as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50330992((3-hydroxyphenyl)(5-(2-hydroxyphenyl)thiophen-2-yl...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human placenta 17beta-HSD2 using [2,4,6,7-3H]-17beta-estradiol as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50330994((4-fluoro-3-hydroxyphenyl)(5-(3-hydroxyphenyl)thio...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human placenta 17beta-HSD1 using [2,4,6,7-3H]-estrone as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50331000(CHEMBL1277709 | [5-(3-Fluoro-4-hydroxyphenyl)-2-th...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human placenta 17beta-HSD1 using [2,4,6,7-3H]-estrone as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50330998((5-(2-fluoro-3-hydroxyphenyl)thiophen-2-yl)(3-hydr...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human placenta 17beta-HSD2 using [2,4,6,7-3H]-17beta-estradiol as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50261942(6-(3-Hydroxyphenyl)-1-phenyl-2-naphthol | CHEMBL46...)
Affinity DataIC50:  20nMAssay Description:Displacement of [3H]E1 from human placental 17beta-HSD1 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50331005(CHEMBL1277884 | [5-(3-Ethyl-4-hydroxyphenyl)-2-thi...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human placenta 17beta-HSD1 using [2,4,6,7-3H]-estrone as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50330993((4-fluoro-3-hydroxyphenyl)(5-(4-hydroxyphenyl)thio...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human placenta 17beta-HSD1 using [2,4,6,7-3H]-estrone as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50330988((3-hydroxyphenyl)(5-(3-hydroxyphenyl)thiophen-2-yl...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human placenta 17beta-HSD1 using [2,4,6,7-3H]-estrone as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335818(6-(3-Hydroxyphenyl)-1-(pyridin-3-yl)-2-naphthol | ...)
Affinity DataIC50:  26nMAssay Description:Displacement of [3H]E1 from human placental 17beta-HSD1 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50330999(CHEMBL1277708 | [5-(4-Hydroxy-3-methylphenyl)-2-th...)
Affinity DataIC50:  27nMAssay Description:Inhibition of 17beta-HSD1 in human T47D cells using [2,4,6,7-3H]-estrone as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50299655(2-Fluoro-4-[5-(3-fluoro-5-hydroxyphenyl)thien-2-yl...)
Affinity DataIC50:  29nMAssay Description:Inhibition of human placental 17betaHSD1 by radiodetection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50330997((5-(4-fluoro-3-hydroxyphenyl)thiophen-2-yl)(3-hydr...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human placenta 17beta-HSD1 using [2,4,6,7-3H]-estrone as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50330991((3-hydroxyphenyl)(5-(4-hydroxyphenyl)thiophen-2-yl...)
Affinity DataIC50:  30nMAssay Description:Inhibition of 17beta-HSD1 in human T47D cells using [2,4,6,7-3H]-estrone as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50330991((3-hydroxyphenyl)(5-(4-hydroxyphenyl)thiophen-2-yl...)
Affinity DataIC50:  33nMAssay Description:Inhibition of human placenta 17beta-HSD1 using [2,4,6,7-3H]-estrone as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335817(6-(3-hydroxyphenyl)-1-(6-methoxypyridin-3-yl)napht...)
Affinity DataIC50:  33nMAssay Description:Displacement of [3H]E1 from human placental 17beta-HSD1 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50331006(CHEMBL1277885 | [2-(4-Hydroxy-3-methylphenyl)-1,3-...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human placenta 17beta-HSD1 using [2,4,6,7-3H]-estrone as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335816(1,6-Bis(3-hydroxyphenyl)-2-naphthol | CHEMBL165065...)
Affinity DataIC50:  36nMAssay Description:Displacement of [3H]E1 from human placental 17beta-HSD1 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50299659(4-[5-(3-Hydroxyphenyl)-2-thienyl]-2-(trifluorometh...)
Affinity DataIC50:  38nMAssay Description:Inhibition of human placental 17betaHSD1 by radiodetection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335816(1,6-Bis(3-hydroxyphenyl)-2-naphthol | CHEMBL165065...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50299651(3-Fluoro-5-[5-(4-hydroxyphenyl)-2-thienyl]phenol |...)
Affinity DataIC50:  42nMAssay Description:Inhibition of human placental 17betaHSD1 by radiodetection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50299633(4-[5-(3-Hydroxyphenyl)-2-thienyl)-2-methyl]phenol ...)
Affinity DataIC50:  46nMAssay Description:Inhibition of human placental 17betaHSD1 by radiodetection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50330994((4-fluoro-3-hydroxyphenyl)(5-(3-hydroxyphenyl)thio...)
Affinity DataIC50:  49nMAssay Description:Inhibition of human placenta 17beta-HSD2 using [2,4,6,7-3H]-17beta-estradiol as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM25831(4-[2-(3-hydroxyphenyl)-1,3-thiazol-5-yl]phenol | h...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human placental 17betaHSD1 by radiodetection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM25831(4-[2-(3-hydroxyphenyl)-1,3-thiazol-5-yl]phenol | h...)
Affinity DataIC50:  50nMpH: 7.0 T: 2°CAssay Description:Tritiated E1 was incubated with 17beta-HSD1, cofactor, and inhibitor. The amount of labeled E2 formed was quantified by HPLC. Detection and quantific...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)
Affinity DataIC50:  50nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50299654(4-Fluoro-1,1':4',1''-terphenyl-3,3''-diol | CHEMBL...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human placental 17betaHSD1 by radiodetection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335819(1-(3-Aminophenyl)-6-(3-hydroxyphenyl)-2-naphthol |...)
Affinity DataIC50:  53nMAssay Description:Displacement of [3H]E1 from human placental 17beta-HSD1 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50299653(2,6-Difluoro-4-[5-(3-hydroxyphenyl)-2-thienyl]phen...)
Affinity DataIC50:  56nMAssay Description:Inhibition of human placental 17betaHSD1 by radiodetection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50330997((5-(4-fluoro-3-hydroxyphenyl)thiophen-2-yl)(3-hydr...)
Affinity DataIC50:  57nMAssay Description:Inhibition of human placenta 17beta-HSD2 using [2,4,6,7-3H]-17beta-estradiol as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50299647(2-Fluoro-4-[5-(3-hydroxyphenyl)-3-thienyl]phenol |...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human placental 17betaHSD1 by radiodetection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50299645(4-[5-(3-Hydroxyphenyl)-3-thienyl]-2-methylphenol |...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human placental 17betaHSD1 by radiodetection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335820(6-(3-Hydroxyphenyl)-1-(pyridin-4-yl)-2-naphthol | ...)
Affinity DataIC50:  64nMAssay Description:Displacement of [3H]E1 from human placental 17beta-HSD1 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM25850(3-[5-(4-hydroxyphenyl)thiophen-2-yl]phenol | hydro...)
Affinity DataIC50:  69nMAssay Description:Inhibition of human placental 17betaHSD1 by radiodetection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM25850(3-[5-(4-hydroxyphenyl)thiophen-2-yl]phenol | hydro...)
Affinity DataIC50:  69nMpH: 7.0 T: 2°CAssay Description:Tritiated E1 was incubated with 17beta-HSD1, cofactor, and inhibitor. The amount of labeled E2 formed was quantified by HPLC. Detection and quantific...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50330993((4-fluoro-3-hydroxyphenyl)(5-(4-hydroxyphenyl)thio...)
Affinity DataIC50:  69nMAssay Description:Inhibition of human placenta 17beta-HSD2 using [2,4,6,7-3H]-17beta-estradiol as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335821(1-(3-Furyl)-6-(3-hydroxyphenyl)-2-naphthol | CHEMB...)
Affinity DataIC50:  70nMAssay Description:Displacement of [3H]E1 from human placental 17beta-HSD1 after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50335815(CHEMBL1650658 | N-{3-[2-Hydroxy-6-(3-hydroxyphenyl...)
Affinity DataIC50:  71nMAssay Description:Displacement of [3H]E1 from 17beta-HSD1 in human T47D cells after 10 mins by fluid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM25855(3-[4-(4-hydroxyphenyl)thiophen-2-yl]phenol | hydro...)
Affinity DataIC50:  77nMAssay Description:Inhibition of human placental 17betaHSD1 by radiodetection assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM25855(3-[4-(4-hydroxyphenyl)thiophen-2-yl]phenol | hydro...)
Affinity DataIC50:  77nMpH: 7.0 T: 2°CAssay Description:Tritiated E1 was incubated with 17beta-HSD1, cofactor, and inhibitor. The amount of labeled E2 formed was quantified by HPLC. Detection and quantific...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
Saarland University

Curated by ChEMBL
LigandPNGBDBM50331003((5-(3,4-dihydroxyphenyl)thiophen-2-yl)(3-hydroxyph...)
Affinity DataIC50:  86nMAssay Description:Inhibition of human placenta 17beta-HSD1 using [2,4,6,7-3H]-estrone as substrate after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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