BindingDB PrimarySearch

Found 164 with Last Name = 'whitaker' and Initial = 't'

RNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL

Ki: 310nMAssay Description:Inhibition of HCV NS5B polymerase S282T mutant assessed as incorporation of [alpha32P]UTP into newly synthesized RNA by liquid scintillation countingMore data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
GoogleScholar

KEGG PC cid PC sid

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RNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL

BDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)

Ki: 2.20E+4nMAssay Description:Inhibition of HCV NS5B polymerase S282T mutant assessed as incorporation of [alpha32P]UTP into newly synthesized RNA by liquid scintillation countingMore data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
GoogleScholar

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)

IC50: 25nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

CHEMBL KEGG PC cid PC sid Similars

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)

IC50: 25nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

CHEMBL KEGG PC cid PC sid Similars

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)

IC50: 47nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 3a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

CHEMBL KEGG PC cid PC sid Similars

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)

IC50: 47nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 6a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

CHEMBL KEGG PC cid PC sid Similars

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)

IC50: 47nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 3a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

CHEMBL KEGG PC cid PC sid Similars

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)

IC50: 47nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 6a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

CHEMBL KEGG PC cid PC sid Similars

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)

IC50: 63nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

CHEMBL KEGG PC cid PC sid Similars

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)

IC50: 63nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

CHEMBL KEGG PC cid PC sid Similars

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)

IC50: 70nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 4a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)

IC50: 70nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 4a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

CHEMBL KEGG PC cid PC sid Similars

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)

IC50: 96nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)

IC50: 96nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)

IC50: 97nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 5a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

CHEMBL KEGG PC cid PC sid Similars

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)

IC50: 97nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 5a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

CHEMBL KEGG PC cid PC sid Similars

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)

IC50: 130nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 6a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)

IC50: 130nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 6a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)

IC50: 180nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)

IC50: 180nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)

IC50: 190nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 2a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

CHEMBL KEGG PC cid PC sid Similars

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50271224(2'-C-Methyl-uridine-5'-triphosphate | CHEMBL521487)

IC50: 190nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 2a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

CHEMBL KEGG PC cid PC sid Similars

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)

IC50: 290nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 2a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)

IC50: 290nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 2a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)

IC50: 380nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 3a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)

IC50: 380nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 3a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

Purchase CHEMBL KEGG PC cid PC sid Similars

Details Article PubMed

RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)

IC50: 430nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 5a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)

IC50: 430nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 5a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)

IC50: 570nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 4a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)

IC50: 570nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 4a infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

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Cytochrome P450 3A4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL

BDBM50432235(CHEMBL2347323)

IC50: 1.50E+3nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

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DNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Emory University

Curated by ChEMBL

BDBM50090910(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)

IC50: 2.40E+3nMAssay Description:Inhibition of human DNA polymerase alpha using 5' end radiolabeled 24nt DNA/48nt DNA as primer/template after 5 mins by PAGE analysisMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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3D Structure (crystal)

Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University School Of Medicine

Curated by ChEMBL

BDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)

IC50: 3.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Emory University School Of Medicine

Curated by ChEMBL

BDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)

IC50: 3.00E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Cytochrome P450 3A4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL

BDBM50387086(CHEMBL2047191)

IC50: 3.10E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

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Adenosine deaminase(Homo sapiens (Human))
Emory University

Curated by ChEMBL

BDBM50356463(CHEMBL1911841)

IC50: 3.70E+3nMAssay Description:Inhibition of adenosine deaminase assessed as conversion of adenosine to inosineMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

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DNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Emory University

Curated by ChEMBL

BDBM50090910(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)

IC50: 4.30E+3nMAssay Description:Inhibition of human DNA polymerase alpha using 5-end radiolabeled 24nt to 48nt DNA as primer template after 5 mins in presence of dCTP/dGTP/dTTP/dATP...More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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3D Structure (crystal)

DNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Emory University

Curated by ChEMBL

BDBM50090910(3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di...)

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

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3D Structure (crystal)

Cytochrome P450 3A4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL

BDBM50432236(CHEMBL2347159)

IC50: 5.10E+3nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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RNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL

BDBM50484706(CHEMBL1950241)

IC50: 6.00E+3nMAssay Description:Inhibition of Hepatitis C virus NS5B Cdelta 21 RNA dependent RNA polymerase S282T mutant expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
GoogleScholar

PC cid PC sid

Details Article PubMed

RNA-directed RNA polymerase(Hepacivirus C)
Pharmasset

Curated by ChEMBL

BDBM50484704(CHEMBL1950242)

IC50: 6.00E+3nMAssay Description:Inhibition of Hepatitis C virus NS5B Cdelta 21 RNA dependent RNA polymerase S282T mutant expressed in Escherichia coli BL21(DE3)More data for this Ligand-Target Pair

PDB
UniProtKB/TrEMBL
GoogleScholar

PC cid PC sid

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Cytochrome P450 3A4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL

BDBM50432234(CHEMBL2347328)

IC50: 6.50E+3nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

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Cytochrome P450 3A4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL

BDBM294045(US10106571, Example 2 | US10106571, Example 23)

IC50: 6.80E+3nMAssay Description:Inhibition of human CYP3A4 using ketoconazole as substrateMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid

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Cytochrome P450 3A4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL

BDBM50432233(CHEMBL2347337)

IC50: 6.90E+3nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

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Cytochrome P450 3A4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL

BDBM50387084(BMS-790052 | DACLATASVIR)

IC50: 7.20E+3nMAssay Description:Inhibition of human CYP3A4More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Cytochrome P450 3A4(Homo sapiens (Human))
Veterans Affairs Medical Center

Curated by ChEMBL

BDBM50387084(BMS-790052 | DACLATASVIR)

IC50: 7.20E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)

IC50: 7.30E+3nMAssay Description:Inhibition of NS5B polymerase S282T mutant in HCV genotype 1b infected in human HuH7 replicon cells after 96 hrs by RT-PCR analysisMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

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RNA-directed RNA polymerase(Hepatitis C virus)
Emory University School Of Medicine

Curated by ChEMBL

BDBM50333129(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1...)

PDB Reactome pathway
UniProtKB/TrEMBL
B.MOAD GoogleScholar

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Neutrophil elastase(Homo sapiens (Human))
Emory University

Curated by ChEMBL

BDBM50442864(CHEMBL2441773)

IC50: 7.80E+3nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

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Neutrophil elastase(Homo sapiens (Human))
Emory University

Curated by ChEMBL

BDBM50326056((1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazin...)

IC50: 8.00E+3nMAssay Description:Inhibition of human neutrophil elastaseMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

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Displayed 1 to 50 (of 164 total ) | Next | Last >>

Filter my 164 hits

Targets 11▿
- RNA-directed RNA polymerase 96
- Cytochrome P450 1A2 10
- Cytochrome P450 2C9 10
- Cytochrome P450 2D6 10
- Cytochrome P450 3A4 10
- DNA polymerase alpha catalytic subunit 7
- DNA polymerase beta 7
- Potassium voltage-gated channel subfamily H member 2 6
- Plasminogen 4
- Neutrophil elastase 3
- Adenosine deaminase 1
- ...
Publications 8▿
- J Med Chem 62: 1859-1874 (2019) 104
- Bioorg Med Chem Lett 23: 2031-4 (2013) 20
- J Med Chem 60: 5424-5437 (2017) 14
- Bioorg Med Chem Lett 22: 4864-8 (2012) 12
- Bioorg Med Chem Lett 23: 6325-30 (2013) 7
- Bioorg Med Chem Lett 21: 7094-8 (2011) 4
- Antimicrob Agents Chemother 52: 458-64 (2008) 2
- Bioorg Med Chem Lett 21: 6788-92 (2011) 1
Institutions 5▿
- Emory University School Of Medicine 104
- Emory University 34
- Veterans Affairs Medical Center 20
- Rfs Pharma 4
- Pharmasset 2
Affinity: 21 to 1.0E+5 nM▿
- Ki 2
- IC50 104
- EC50 58
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 10