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Found 143 with Last Name = 'whitworth' and Initial = 'c'
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12569(GTC000006A | N-(6-chloronaphthalen-2-yl)-N'-[(3S)-...)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12557(6-chloro-N-[(3S)-2-oxo-1-[(2S)-1-oxo-1-(piperidin-...)
Affinity DataKi:  1nM ΔG°:  -51.4kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17654(5-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morph...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12558(6-chloro-N-methyl-N-[(3S)-2-oxo-1-[(2S)-1-oxo-1-(p...)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12567(2-[(6-chloronaphthalene-2-)[(3S)-1-[(2S)-1-(morpho...)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12568(2-[(6-chloronaphthalene-2-)[(3S)-1-[(2S)-1-(morpho...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12561(N-[(3S)-1-[(2S)-1-{2-azabicyclo[2.2.2]octan-2-yl}-...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17643((E)-2-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(m...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17641(5-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morph...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17653(2-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morph...)
Affinity DataKi:  5nM ΔG°:  -46.9kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12538(6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  6nM ΔG°:  -46.5kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12538(6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  6nM ΔG°:  -46.9kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12566(6-chloro-N-methyl-N-[(3S)-1-[(2S)-1-(morpholin-4-y...)
Affinity DataKi:  10nM ΔG°:  -45.7kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17642((E)-2-(4-chlorophenyl)-N-[(3S)-1-[(2S)-1-(morpholi...)
Affinity DataKi:  11nM ΔG°:  -45.0kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12562(6-chloro-N-[(3S)-1-[(2S)-1-[(1R,5S)-3,7-diazabicyc...)
Affinity DataKi:  13nM ΔG°:  -45.0kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12547(6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  15nM ΔG°:  -44.2kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12574(6-chloro-N-[(3R)-2-oxo-1-[(2S)-1-oxo-1-(piperidin-...)
Affinity DataKi:  16nM ΔG°:  -44.5kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17656(6-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morph...)
Affinity DataKi:  24nM ΔG°:  -43.1kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12573(6-chloro-N-[(3R)-2-oxo-1-[(2R)-1-oxo-1-(piperidin-...)
Affinity DataKi:  40nM ΔG°:  -42.2kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12546(5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  47nM ΔG°:  -41.4kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12560(6-chloro-N-[(3S)-2-oxo-1-[(2S)-1-oxo-1-(pyrrolidin...)
Affinity DataKi:  50nM ΔG°:  -41.7kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12571(6-chloro-N-[(3R)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  53nM ΔG°:  -41.5kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12554(N-[(3S)-1-[2-(azepan-1-yl)-2-oxoethyl]-2-oxopyrrol...)
Affinity DataKi:  60nM ΔG°:  -41.2kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12556(6-chloro-N-[(3S)-2-oxo-1-[2-oxo-2-(piperidin-1-yl)...)
Affinity DataKi:  63nM ΔG°:  -41.1kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12555(6-chloro-N-methyl-N-[(3S)-2-oxo-1-[2-oxo-2-(piperi...)
Affinity DataKi:  72nM ΔG°:  -40.8kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12570(6-chloro-N-[(3R)-1-[(2R)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  82nM ΔG°:  -40.4kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12575(6-chloro-N-[(3S)-2-oxo-1-[(2R)-1-oxo-1-(piperidin-...)
Affinity DataKi:  82nM ΔG°:  -40.4kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12550(5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  90nM ΔG°:  -39.8kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17644(6-methyl-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  109nM ΔG°:  -39.3kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12548(5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  112nM ΔG°:  -39.3kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12572(6-chloro-N-[(3S)-1-[(2R)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  160nM ΔG°:  -38.8kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17647(5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  163nM ΔG°:  -38.4kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17645(5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  165nM ΔG°:  -38.3kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12551(6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  170nM ΔG°:  -38.2kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12553(6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  285nM ΔG°:  -37.0kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17646(4-[(E)-2-chloroethenyl]-N-[(3S)-1-[(2S)-1-(morphol...)
Affinity DataKi:  314nM ΔG°:  -36.7kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12563(6-chloro-N-[(3S)-2-oxo-1-[(2S)-1-oxo-1-(piperazin-...)
Affinity DataKi:  320nM ΔG°:  -37.1kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17655(5-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morph...)
Affinity DataKi:  534nM ΔG°:  -35.4kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12552(5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  782nM ΔG°:  -34.5kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17652(5-(5-chlorothiophen-2-yl)-N-[(3S)-1-[(2S)-1-(morph...)
Affinity DataKi:  1.20E+3nM ΔG°:  -33.5kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12564(6-chloro-N-[(3S)-1-[(2S)-1-(4-methylpiperazin-1-yl...)
Affinity DataKi:  2.06E+3nM ΔG°:  -32.5kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17648(5-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  2.90E+3nM ΔG°:  -31.3kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17651(5-(5-chloro-1,3-thiazol-2-yl)-N-[(3S)-1-[(2S)-1-(m...)
Affinity DataKi:  3.23E+3nM ΔG°:  -31.0kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17649(6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  3.67E+3nM ΔG°:  -30.7kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12549(6-chloro-N-[(3S)-1-[(2S)-1-(morpholin-4-yl)-1-oxop...)
Affinity DataKi:  4.16E+3nM ΔG°:  -30.4kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM12559(6-chloro-N-{1-[2-methyl-1-oxo-1-(piperidin-1-yl)pr...)
Affinity DataKi:  1.06E+4nM ΔG°:  -28.4kJ/molepH: 7.8 T: 2°CAssay Description:The inhibitory effect of test compound for human fXa was determined by using the chromogenic substrate. The hydrolysis rates of chromogenic substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM17650(5-(5-chloro-1,3,4-thiadiazol-2-yl)-N-[(3S)-1-[(2S)...)
Affinity DataKi: >1.58E+4nM ΔG°: >-27.1kJ/molepH: 7.4 T: 2°CAssay Description:The ability of test compounds to inhibit human fXa in vitro was determined in a fluorescence assay using rhodamime 110, bis-(Boc-L-glycylglycyl-L-arg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50395536(CHEMBL2164412)
Affinity DataIC50:  3.98nMAssay Description:Inhibition of IKK2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50395538(CHEMBL2164410)
Affinity DataIC50:  5.01nMAssay Description:Inhibition of IKK2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50395536(CHEMBL2164412)
Affinity DataIC50:  6.31nMAssay Description:Inhibition of IKK1 in presence of 1 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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