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Found 46 with Last Name = 'williams' and Initial = 'et'
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50088512(CHEBI:59609 | CHEMBL3527338)
Affinity DataKi:  4.32E+3nMAssay Description:Reversible inhibition of human CES1 assessed as hydrolysis of 4NPA to 4NPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50088513(CHEMBL3526940)
Affinity DataKi:  2.48E+4nMAssay Description:Reversible inhibition of human CES1 assessed as hydrolysis of 4NPA to 4NPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50088514(CHEBI:88735 | CHEMBL3526740)
Affinity DataKi:  3.55E+5nMAssay Description:Reversible inhibition of human CES1 assessed as hydrolysis of 4NPA to 4NPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50003616(2-n-propyl-n-valeric acid | CHEMBL109 | DPA | Di-n...)
Affinity DataKi:  3.63E+5nMAssay Description:Inhibition of human CES1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50088516(CHEMBL3526990)
Affinity DataKi:  4.68E+5nMAssay Description:Reversible inhibition of human CES1 assessed as hydrolysis of 4NPA to 4NPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50088515(CHEMBL3526991)
Affinity DataKi:  7.07E+5nMAssay Description:Reversible inhibition of human CES1 assessed as hydrolysis of 4NPA to 4NPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCocaine esterase(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50003616(2-n-propyl-n-valeric acid | CHEMBL109 | DPA | Di-n...)
Affinity DataKi:  7.90E+6nMAssay Description:Inhibition of human CES2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50613996(CHEMBL5281961)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM585727(8-chloro-1-(2,6-dichlorophenyl)-5- (2-hydroxyethox...)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50613997(CHEMBL5280047)
Affinity DataIC50:  11nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM585709(8-chloro-1-(2,6-dichlorophenyl)-5- (2-(2-(2-(2- hy...)
Affinity DataIC50:  25nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50613999(CHEMBL5289977)
Affinity DataIC50:  27nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613992(CHEMBL5282689)
Affinity DataIC50:  50nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM585682(8-chloro-1-(2,6-dichlorophenyl)-5- (2,3-dihydroxyp...)
Affinity DataIC50:  80nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50614001(CHEMBL5278366)
Affinity DataIC50:  87nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50614002(CHEMBL5285569)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM585681((R)-8-chloro-1-(2,6- dichlorophenyl)-5-(2,3- dihyd...)
Affinity DataIC50:  100nMAssay Description:Inhibition of GIRK1/2 (unknown origin) channelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM585681((R)-8-chloro-1-(2,6- dichlorophenyl)-5-(2,3- dihyd...)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50613994(CHEMBL5269440)
Affinity DataIC50:  140nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM585680(US11530213, Example 1)
Affinity DataIC50:  150nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM585699(8-chloro-1-(2,6-dichlorophenyl)-5- (3-(2,3-dihydro...)
Affinity DataIC50:  170nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50613993(CHEMBL5286246)
Affinity DataIC50:  190nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613993(CHEMBL5286246)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human GIRK1/2 channelMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613995(CHEMBL5290509)
Affinity DataIC50:  220nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM585688(8-chloro-1-(2,6-dichlorophenyl)-5- ((1,3-dihydroxy...)
Affinity DataIC50:  250nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50614000(CHEMBL5286244)
Affinity DataIC50:  290nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50088512(CHEBI:59609 | CHEMBL3527338)
Affinity DataIC50:  1.96E+3nMAssay Description:Time-dependent inhibition of human CES1 assessed as hydrolysis of 4NPA to 4NP preincubated for 30 mins followed by 4NPA additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50088512(CHEBI:59609 | CHEMBL3527338)
Affinity DataIC50:  2.27E+3nMAssay Description:Time-dependent inhibition of human CES1 assessed as hydrolysis of 4NPA to 4NP preincubated for 60 mins followed by 4NPA additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50088512(CHEBI:59609 | CHEMBL3527338)
Affinity DataIC50:  2.51E+3nMAssay Description:Time-dependent inhibition of human CES1 assessed as hydrolysis of 4NPA to 4NP preincubated for 10 mins followed by 4NPA additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50613998(CHEMBL5277008)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of recombinant human GIRK1/4 channelMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613992(CHEMBL5282689)
Affinity DataIC50:  2.42E+4nMAssay Description:Inhibition of recombinant human Cav1.2More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613993(CHEMBL5286246)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of recombinant hERG in the presence of dofetilide by competitive binding assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613992(CHEMBL5282689)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of recombinant hERG in the presence of dofetilide by competitive binding assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50613992(CHEMBL5282689)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of recombinant human KCNQ1More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM585681((R)-8-chloro-1-(2,6- dichlorophenyl)-5-(2,3- dihyd...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human KCNQ1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM585680(US11530213, Example 1)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human KCNQ1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM585681((R)-8-chloro-1-(2,6- dichlorophenyl)-5-(2,3- dihyd...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant hERG in the presence of dofetilide by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM585680(US11530213, Example 1)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant hERG in the presence of dofetilide by competitive binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50613993(CHEMBL5286246)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human KCNQ1More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM585681((R)-8-chloro-1-(2,6- dichlorophenyl)-5-(2,3- dihyd...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human Cav1.2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50613993(CHEMBL5286246)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human Cav1.2More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM585680(US11530213, Example 1)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human Nav1.5More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM585681((R)-8-chloro-1-(2,6- dichlorophenyl)-5-(2,3- dihyd...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human Nav1.5More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613993(CHEMBL5286246)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human Nav1.5More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50613992(CHEMBL5282689)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human Nav1.5More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM585680(US11530213, Example 1)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of recombinant human Cav1.2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed