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Found 102 with Last Name = 'wovkulich' and Initial = 'pm'
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227529(US9334278, I-18)
Affinity DataIC50:  2nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227523(US9334278, I-12)
Affinity DataIC50:  3.20nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227549(US9334278, I-37)
Affinity DataIC50:  4.80nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227537(US9334278, I-26)
Affinity DataIC50:  5.60nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227535(US9334278, I-24)
Affinity DataIC50:  5.90nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227512(US9334278, I-1)
Affinity DataIC50:  8.5nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM291171(US9580411, Example 86)
Affinity DataIC50:  9nMT: 2°CAssay Description:IC50s (effective concentration) of compounds on the human TRPA1 channel were determined using a Hamamatsu FDSS fluorescence plate reader. CHO cells e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50328264(5-(2-chlorophenyl)-3-isopropyl-7-nitro-2,10-dihydr...)
Affinity DataIC50:  10nMAssay Description:Inhibition of CDK2-cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426474(CHEMBL1980391)
Affinity DataIC50:  10nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227522(US9334278, I-11)
Affinity DataIC50:  10.9nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227524(US9334278, I-13)
Affinity DataIC50:  12.8nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM291170(2-[N-(Propan-2-yl)(4-fluorobenzene)sulfonamido]-N-...)
Affinity DataIC50:  13nMT: 2°CAssay Description:IC50s (effective concentration) of compounds on the human TRPA1 channel were determined using a Hamamatsu FDSS fluorescence plate reader. CHO cells e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227516(US9334278, I-5)
Affinity DataIC50:  13.7nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227520(US9334278, I-9)
Affinity DataIC50:  15.5nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50328256(5-(2-fluorophenyl)-2,10-dihydrobenzo[e]pyrazolo[4,...)
Affinity DataIC50:  16nMAssay Description:Inhibition of CDK2-cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227521(US9334278, I-10)
Affinity DataIC50:  16.3nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50328279(5-(2-fluorophenyl)-2,10-dihydrobenzo[e]pyrazolo[4,...)
Affinity DataIC50:  17nMAssay Description:Inhibition of CDK2-cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227517(US9334278, I-6)
Affinity DataIC50:  17.1nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227542(US9334278, I-31)
Affinity DataIC50:  17.8nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227538(US9334278, I-27)
Affinity DataIC50:  18.8nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50328267(5-(2-chlorophenyl)-7-nitro-3-(1H-pyrrol-2-yl)-2,10...)
Affinity DataIC50:  20nMAssay Description:Inhibition of CDK2-cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227514(US9334278, I-3)
Affinity DataIC50:  21.1nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50328280(CHEMBL1258022 | N-(5-(2-chlorophenyl)-2,10-dihydro...)
Affinity DataIC50:  24nMAssay Description:Inhibition of CDK2-cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426474(CHEMBL1980391)
Affinity DataIC50:  24nMAssay Description:Inhibition of CHK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227533(US9334278, I-22)
Affinity DataIC50:  25.1nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227513(US9334278, I-2)
Affinity DataIC50:  27.4nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426474(CHEMBL1980391)
Affinity DataIC50:  28nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM291169(1-(4-Fluoro-N-isopropylphenylsulfonamido)-N-((6-(6...)
Affinity DataIC50:  29nMT: 2°CAssay Description:IC50s (effective concentration) of compounds on the human TRPA1 channel were determined using a Hamamatsu FDSS fluorescence plate reader. CHO cells e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227531(US9334278, I-20)
Affinity DataIC50:  30nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50328258(CHEMBL1257912 | N-(5-(2-chlorophenyl)-2,10-dihydro...)
Affinity DataIC50:  33nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50328257(5-(2-chlorophenyl)-2,10-dihydrobenzo[e]pyrazolo[4,...)
Affinity DataIC50:  34nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426473(CHEMBL2322701)
Affinity DataIC50:  34nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50328255(5-(2-chlorophenyl)-3-methyl-7-nitro-2,10-dihydrobe...)
Affinity DataIC50:  35nMAssay Description:Inhibition of CDK2-cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227525(US9334278, I-14)
Affinity DataIC50:  35.9nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM291163(US9580411, Example 79-(R) | US9580411, Example 79-...)
Affinity DataIC50:  38nMT: 2°CAssay Description:IC50s (effective concentration) of compounds on the human TRPA1 channel were determined using a Hamamatsu FDSS fluorescence plate reader. CHO cells e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50328258(CHEMBL1257912 | N-(5-(2-chlorophenyl)-2,10-dihydro...)
Affinity DataIC50:  38nMAssay Description:Inhibition of CDK2-cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50328256(5-(2-fluorophenyl)-2,10-dihydrobenzo[e]pyrazolo[4,...)
Affinity DataIC50:  39nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50328274(7-fluoro-5-(2-fluorophenyl)-3-methyl-2,10-dihydrob...)
Affinity DataIC50:  40nMAssay Description:Inhibition of CDK2-cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227515(US9334278, I-4)
Affinity DataIC50:  42.8nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227543(US9334278, I-32)
Affinity DataIC50:  43.7nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50328281(CHEMBL1258141 | N'-[5-(2-chlorophenyl)-2,10-dihydr...)
Affinity DataIC50:  46nMAssay Description:Inhibition of CDK2-cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227528(US9334278, I-17)
Affinity DataIC50:  49.9nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426473(CHEMBL2322701)
Affinity DataIC50:  50nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50328269(5-(2-chlorophenyl)-7-nitro-3-(pyridin-4-yl)-2,10-d...)
Affinity DataIC50:  50nMAssay Description:Inhibition of CDK2-cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK [360-635](Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM227519(US9334278, I-8)
Affinity DataIC50:  51.3nMT: 2°CAssay Description:Assay plates: 96-well MultiScreen 0.65 μm filter plates (Millipore Cat. No.: MADVNOB 10) Streptavidin coated beads: Streptavidin Sepharose™,...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM291163(US9580411, Example 79-(R) | US9580411, Example 79-...)
Affinity DataIC50:  55nMT: 2°CAssay Description:IC50s (effective concentration) of compounds on the human TRPA1 channel were determined using a Hamamatsu FDSS fluorescence plate reader. CHO cells e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransient receptor potential cation channel subfamily A member 1(Homo sapiens (Human))
Hoffmann-La Roche

US Patent
LigandPNGBDBM291168(2,2-Dideuterio-2-(4-fluoro-N-isopropylphenylsulfon...)
Affinity DataIC50:  58nMT: 2°CAssay Description:IC50s (effective concentration) of compounds on the human TRPA1 channel were determined using a Hamamatsu FDSS fluorescence plate reader. CHO cells e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAurora kinase A(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50426474(CHEMBL1980391)
Affinity DataIC50:  58nMAssay Description:Inhibition of aurora-A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50328272(5-(2-fluorophenyl)-3-methyl-2,10-dihydrobenzo[e]py...)
Affinity DataIC50:  64nMAssay Description:Inhibition of CDK2-cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1/G1/S-specific cyclin-E2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50328260(5-(2-chlorophenyl)-7-nitro-2,10-dihydrobenzo[e]pyr...)
Affinity DataIC50:  70nMAssay Description:Inhibition of CDK2-cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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