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Found 1187 with Last Name = 'wrigglesworth' and Initial = 'j'
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM239101(US10195181, Example 2.2 | US9403810, 2.2)
Affinity DataIC50:  0.900nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM239101(US10195181, Example 2.2 | US9403810, 2.2)
Affinity DataIC50:  0.900nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCTP synthase 2(Rattus norvegicus)TBA
LigandPNGBDBM50609673(CHEMBL5267968)
Affinity DataIC50:  1nMAssay Description:Inhibition of rat CTPS2 preincubated for 10 mins followed by substrate addition and measured after 30 to 60 mins by RFMS assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetKallikrein-1(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652564(N5-((4-methyl-6-(8-methyl-3-(trifluoromethyl)-5,6-...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetKallikrein-1(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652566((S*)-N5-((4-methyl-6-(8-methyl-3-(trifluoromethyl)...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetKallikrein-1(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652569(N5-((4-ethyl-6-(3-(trifluoromethyl)-5,6-dihydro-[1...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652690(4-chloro-6-N-{[2-({2-methyl-5H,6H,7H,8H-imidazo[1,...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652680(N5-((2-((3-isopropyl-3-azabicyclo[3.2.1]octan-8-yl...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652682(5-N-({2-[(1-isopropylpiperidin-4-yl)methoxy]pyridi...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652684(4-{[(4-{[(1-aminoisoquinolin-5-yl)amino]methyl}pyr...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652688(4-fluoro-6-N-[(2-{5H,6H,7H,8H-imidazo[1,2-a]pyridi...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetKallikrein-1(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652764(N5-((3-methyl-5-(3-(trifluoromethyl)-5,6-dihydro-[...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652744(8-methyl-N-((2-((1-methylpiperidin-4-yl)methoxy)py...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetKallikrein-1(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652573(2-chloro-N-((4-methyl-6-(3-(trifluoromethyl)-5,6-d...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652716((R*)-N5-((2-((5,6,7,8-tetrahydroimidazo[1,2-a]pyri...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652715((S*)-N5-((2-((5,6,7,8-tetrahydroimidazo[1,2-a]pyri...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652713(3-[(4-{[(1-amino-4-chloroisoquinolin-6-yl)amino]me...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652462(5-N-[(2-{5H,6H,7H,8H-imidazo[1,2-a]pyridin-7-ylmet...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652548(N5-((4-methyl-6-(3-(trifluoromethyl)-5,6-dihydro-[...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM239117(US10195181, Example 22c | US9403810, 22)
Affinity DataIC50:  1.40nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM239132(US9403810, 22c)
Affinity DataIC50:  1.40nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase SMURF1 [420-757](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM239094(US10195181, Example 1.3 | US9403810, 1.3)
Affinity DataIC50:  1.80nMT: 2°CAssay Description:For the biochemical assay panel, 50 nl of the test compounds, reference compounds and buffer/DMSO control are transferred to the respective wells of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetE3 ubiquitin-protein ligase SMURF1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM239094(US10195181, Example 1.3 | US9403810, 1.3)
Affinity DataIC50:  1.80nMAssay Description:To determine the HECT E3 ligase selectivity of the compounds, a panel of biochemical HECT E3 ligase autoubiquitinylation assays was employed (Smurf-1...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652428(N-({6-[(1-methylpiperidin-4-yl)methoxy]pyridin-3-y...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652428(N-({6-[(1-methylpiperidin-4-yl)methoxy]pyridin-3-y...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652432(6-N-({6-[(1-isopropylpiperidin-4-yl)methoxy]pyridi...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652433(6-N-({2-[(1-methylpiperidin-4-yl)methoxy]pyrimidin...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652744(8-methyl-N-((2-((1-methylpiperidin-4-yl)methoxy)py...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652428(N-({6-[(1-methylpiperidin-4-yl)methoxy]pyridin-3-y...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652520(US20240059691, Example 1248 | methyl 4-(((6-(((1-m...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652622(6-N-[(4-{[(1-ethylpiperidin-4-yl)oxy]methyl}-2-flu...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652621(5-N-[(4-{[(1-ethylpiperidin-4-yl)oxy]methyl}-2-flu...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652621(5-N-[(4-{[(1-ethylpiperidin-4-yl)oxy]methyl}-2-flu...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652621(5-N-[(4-{[(1-ethylpiperidin-4-yl)oxy]methyl}-2-flu...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652619(N6-(2-fluoro-4-((((4R*,5S*)-2-methyl-2-azabicyclo[...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652618(N6-(2-fluoro-4-((((4R*,5R*)-2-methyl-2-azabicyclo[...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652617(5-N-[(2-fluoro-4-{[(1-methylpiperidin-4-yl)oxy]met...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652617(5-N-[(2-fluoro-4-{[(1-methylpiperidin-4-yl)oxy]met...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652617(5-N-[(2-fluoro-4-{[(1-methylpiperidin-4-yl)oxy]met...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652617(5-N-[(2-fluoro-4-{[(1-methylpiperidin-4-yl)oxy]met...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652613(N-[(4-{[(1-methylpiperidin-4-yl)oxy]methyl}phenyl)...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652613(N-[(4-{[(1-methylpiperidin-4-yl)oxy]methyl}phenyl)...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652613(N-[(4-{[(1-methylpiperidin-4-yl)oxy]methyl}phenyl)...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652613(N-[(4-{[(1-methylpiperidin-4-yl)oxy]methyl}phenyl)...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652647(6-N-({2-[(1-methylpiperidin-4-yl)methoxy]pyridin-4...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetProthrombin(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652646(5-N-[[2-[(1-methyl-4-piperidyl)methoxy]-4-pyridyl]...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652646(5-N-[[2-[(1-methyl-4-piperidyl)methoxy]-4-pyridyl]...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor X(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652646(5-N-[[2-[(1-methyl-4-piperidyl)methoxy]-4-pyridyl]...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652643(6-N-({1-[2-(1-methylpiperidin-4-yl)ethyl]pyrazol-4...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Kalvista Pharmaceuticals

US Patent
LigandPNGBDBM652646(5-N-[[2-[(1-methyl-4-piperidyl)methoxy]-4-pyridyl]...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibition of related proteases was determined using an (C50 assay based on standard literature methods (see e.g. Shori et al., Biochem. Pha...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
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