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Found 111 with Last Name = 'wyss' and Initial = 'p'
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128532(5-(7-Chloro-10-methylsulfanyl-3,4-dihydro-1H-pyraz...)
Affinity DataIC50:  2nMAssay Description:Antibacterial activity of TMP-susceptible Dihydrofolate reductase against Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128535(5-(4-Methoxy-9-methyl-6,9-dihydro-7H-[1,3]dioxolo[...)
Affinity DataIC50:  2.80nMAssay Description:Inhibitory activity against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50209958((2S,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-2,3...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50209925((2S,3S,11bS)-9,10-dimethoxy-3-m-tolyl-2,3,4,6,7,11...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128534(5-(4,11-Dimethyl-1,2,4,11-tetrahydro-pyrido[4,3-a]...)
Affinity DataIC50:  4nMAssay Description:Antibacterial activity of TMP-susceptible Dihydrofolate reductase against Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128540(5-(1,3,4,9-Tetrahydro-beta-carbolin-2-ylmethyl)-py...)
Affinity DataIC50:  4nMAssay Description:Antibacterial activity of TMP-susceptible Dihydrofolate reductase against Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128538(5-[7-Methoxy-4-(3-nitro-phenyl)-3,4-dihydro-1H-iso...)
Affinity DataIC50:  6nMAssay Description:Antibacterial activity of TMP-susceptible Dihydrofolate reductase against Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128533(5-[4-(2,4-Dichloro-phenyl)-6,7-dimethoxy-3,4-dihyd...)
Affinity DataIC50:  7nMAssay Description:Antibacterial activity of the compound against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128535(5-(4-Methoxy-9-methyl-6,9-dihydro-7H-[1,3]dioxolo[...)
Affinity DataIC50:  9.80nMAssay Description:Antibacterial activity of the compound against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128536(5-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylme...)
Affinity DataIC50:  10nMAssay Description:Antibacterial activity of the compound against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128534(5-(4,11-Dimethyl-1,2,4,11-tetrahydro-pyrido[4,3-a]...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity of TMP-susceptible Dihydrofolate reductase against Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128537(5-(4-Methoxy-9-methyl-6,9-dihydro-7H-[1,3]dioxolo[...)
Affinity DataIC50:  12nMAssay Description:Antibacterial activity of the compound against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50209928((3S,11bS)-9,10-dimethoxy-3-m-tolyl-2,3,4,6,7,11b-h...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128529(5-(4-Methoxy-9-methyl-6,9-dihydro-7H-[1,3]dioxolo[...)
Affinity DataIC50:  21nMAssay Description:Antibacterial activity of the compound against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128537(5-(4-Methoxy-9-methyl-6,9-dihydro-7H-[1,3]dioxolo[...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  27nMAssay Description:Antibacterial activity of the compound against TMP-Resistant Dihydrofolate reductase from Staphylococcus aureus 157/4696More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128529(5-(4-Methoxy-9-methyl-6,9-dihydro-7H-[1,3]dioxolo[...)
Affinity DataIC50:  29nMAssay Description:Inhibitory activity against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128532(5-(7-Chloro-10-methylsulfanyl-3,4-dihydro-1H-pyraz...)
Affinity DataIC50:  31nMAssay Description:Inhibitory activity against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128533(5-[4-(2,4-Dichloro-phenyl)-6,7-dimethoxy-3,4-dihyd...)
Affinity DataIC50:  31nMAssay Description:Inhibitory activity against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50209933((2R,3S,11bS)-9,10-dimethoxy-3-m-tolyl-2,3,4,6,7,11...)
Affinity DataIC50:  32nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus (strain MW2))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128531(5-(7-Benzyl-1-methyl-6-phenyl-3,4-dihydro-1H-pyrro...)
Affinity DataIC50:  42nMAssay Description:Inhibitory activity against TMP-Resistance Dihydrofolate reductase from Staphylococcus aureus 157/4696More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128530(5-(6,7-Dimethoxy-1-methyl-3,4-dihydro-1H-isoquinol...)
Affinity DataIC50:  44nMAssay Description:Antibacterial activity of the compound against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128540(5-(1,3,4,9-Tetrahydro-beta-carbolin-2-ylmethyl)-py...)
Affinity DataIC50:  47nMAssay Description:Inhibitory activity against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50209945((2R,3S,11bS)-3-(3-chlorophenyl)-9,10-dimethoxy-2,3...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128530(5-(6,7-Dimethoxy-1-methyl-3,4-dihydro-1H-isoquinol...)
Affinity DataIC50:  53nMAssay Description:Inhibitory activity against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128538(5-[7-Methoxy-4-(3-nitro-phenyl)-3,4-dihydro-1H-iso...)
Affinity DataIC50:  56nMAssay Description:Inhibitory activity against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus (strain MW2))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128532(5-(7-Chloro-10-methylsulfanyl-3,4-dihydro-1H-pyraz...)
Affinity DataIC50:  73nMAssay Description:Inhibitory activity against TMP-Resistance Dihydrofolate reductase from Staphylococcus aureus 157/4696More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataIC50:  75nMAssay Description:Inhibitory activity of the compound against TMP-susceptible DHFR from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128534(5-(4,11-Dimethyl-1,2,4,11-tetrahydro-pyrido[4,3-a]...)
Affinity DataIC50:  85nMAssay Description:Antibacterial activity against TMP-Resistance Dihydrofolate reductase from Staphylococcus pneumoniae 1/1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50209947((2S,3S,11bS)-9,10-dimethoxy-3-phenyl-2,3,4,6,7,11b...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128536(5-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylme...)
Affinity DataIC50:  210nMAssay Description:Inhibitory activity of TMP-susceptible Dihydrofolate reductase against Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128536(5-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-ylme...)
Affinity DataIC50:  210nMAssay Description:Inhibitory activity of TMP-Resistance DHFR against Staphylococcus pneumoniae 1/1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50209936((3S,11bS)-9,10-dimethoxy-3-phenyl-2,3,4,6,7,11b-he...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50209939((2R,3S,11bS)-9,10-dimethoxy-3-phenyl-2,3,4,6,7,11b...)
Affinity DataIC50:  270nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50209959((2S,3S,11bS)-9,10-dimethoxy-3-p-tolyl-2,3,4,6,7,11...)
Affinity DataIC50:  370nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128531(5-(7-Benzyl-1-methyl-6-phenyl-3,4-dihydro-1H-pyrro...)
Affinity DataIC50:  450nMAssay Description:Antibacterial activity of TMP-susceptible Dihydrofolate reductase against Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128529(5-(4-Methoxy-9-methyl-6,9-dihydro-7H-[1,3]dioxolo[...)
Affinity DataIC50:  520nMAssay Description:Antibacterial activity against TMP-Resistance Dihydrofolate reductase from Staphylococcus pneumoniae 1/1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50209938((2S,3S,11bS)-3-butyl-9,10-dimethoxy-2,3,4,6,7,11b-...)
Affinity DataIC50:  520nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128531(5-(7-Benzyl-1-methyl-6-phenyl-3,4-dihydro-1H-pyrro...)
Affinity DataIC50:  550nMAssay Description:Inhibitory activity against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50209953(1-(3,4-dimethoxyphenyl)-3-m-tolylpiperidin-4-amine...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50209930((2R,3S,11bS)-9,10-dimethoxy-3-(3-methoxyphenyl)-2,...)
Affinity DataIC50:  650nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128530(5-(6,7-Dimethoxy-1-methyl-3,4-dihydro-1H-isoquinol...)
Affinity DataIC50:  670nMAssay Description:Antibacterial activity against TMP-Resistance Dihydrofolate reductase from Staphylococcus pneumoniae 1/1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50209952((2R,3S,11bS)-9,10-dimethoxy-3-(pyridin-2-yl)-2,3,4...)
Affinity DataIC50:  990nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128539(5-(3,4-Dihydro-1H-isoquinolin-2-ylmethyl)-pyrimidi...)
Affinity DataIC50:  1.10E+3nMAssay Description:Antibacterial activity of the compound against TMP-susceptible Dihydrofolate reductase from Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128535(5-(4-Methoxy-9-methyl-6,9-dihydro-7H-[1,3]dioxolo[...)
Affinity DataIC50:  1.20E+3nMAssay Description:Antibacterial activity against TMP-Resistance Dihydrofolate reductase from Staphylococcus pneumoniae 1/1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus (strain MW2))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128535(5-(4-Methoxy-9-methyl-6,9-dihydro-7H-[1,3]dioxolo[...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibitory activity against TMP-Resistance Dihydrofolate reductase from Staphylococcus aureus 157/4696More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128537(5-(4-Methoxy-9-methyl-6,9-dihydro-7H-[1,3]dioxolo[...)
Affinity DataIC50:  1.40E+3nMAssay Description:Antibacterial activity against TMP-Resistance Dihydrofolate reductase from Staphylococcus pneumoniae 1/1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50209962((3S,4R)-3-butyl-1-(naphthalen-2-yl)piperidin-4-ami...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50209926((2S,3S,11bS)-9,10-dimethoxy-3-(pyridin-2-yl)-2,3,4...)
Affinity DataIC50:  1.52E+3nMAssay Description:Inhibition of human DPP4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128533(5-[4-(2,4-Dichloro-phenyl)-6,7-dimethoxy-3,4-dihyd...)
Affinity DataIC50:  1.70E+3nMAssay Description:Antibacterial activity against TMP-Resistance Dihydrofolate reductase from Staphylococcus pneumoniae 1/1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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