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Found 2149 with Last Name = 'xian' and Initial = 'j'
TargetEndothelin-1 receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85335(SB 234551 | SB-234551)
Affinity DataKi:  0.130nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50041617((1S,2R,3S)-1-Benzo[1,3]dioxol-5-yl-3-(2-carboxymet...)
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50061077((1S,2R,3S)-1-Benzo[1,3]dioxol-5-yl-3-[2-(2-hydroxy...)
Affinity DataKi:  1.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50041617((1S,2R,3S)-1-Benzo[1,3]dioxol-5-yl-3-(2-carboxymet...)
Affinity DataKi:  21nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50445876(CHEMBL3105692)
Affinity DataKi:  25nMAssay Description:Displacement of 25-[26,27-3H]hydroxycholesterol from RORgammat receptor ligand binding domain (unknown origin) after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50445875(CHEMBL3105671)
Affinity DataKi:  32nMAssay Description:Displacement of 25-[26,27-3H]hydroxycholesterol from RORgammat receptor ligand binding domain (unknown origin) after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50445877(CHEMBL3105681)
Affinity DataKi:  40nMAssay Description:Displacement of 25-[26,27-3H]hydroxycholesterol from RORgammat receptor ligand binding domain (unknown origin) after 60 minsMore data for this Ligand-Target Pair
TargetEndothelin receptor type B(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50061101(4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-...)
Affinity DataKi:  134nMMore data for this Ligand-Target Pair
TargetEndothelin receptor type B(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM50061077((1S,2R,3S)-1-Benzo[1,3]dioxol-5-yl-3-[2-(2-hydroxy...)
Affinity DataKi:  150nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50445878(CHEMBL3105815)
Affinity DataKi:  398nMAssay Description:Displacement of 25-[26,27-3H]hydroxycholesterol from RORgammat receptor ligand binding domain (unknown origin) after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by PDSP Ki Database
LigandPNGBDBM85335(SB 234551 | SB-234551)
Affinity DataKi:  500nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356214(CHEMBL1910471)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50356215(CHEMBL1910473)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50255551(CHEMBL4066904)
Affinity DataIC50:  0.158nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50255543(CHEMBL4082136)
Affinity DataIC50:  0.200nMAssay Description:Agonist activity at CCR10 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50255536(CHEMBL4098864)
Affinity DataIC50:  0.200nMAssay Description:Agonist activity at CXCR3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50255548(CHEMBL4072270)
Affinity DataIC50:  0.251nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50255490(CHEMBL4060139)
Affinity DataIC50:  0.251nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50255564(CHEMBL4062361)
Affinity DataIC50:  0.251nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50255537(CHEMBL4077201)
Affinity DataIC50:  0.316nMAssay Description:Agonist activity at CCR9 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50182266(CHEMBL3818984)
Affinity DataIC50:  0.316nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50182268(CHEMBL3819480)
Affinity DataIC50:  0.316nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50182267(CHEMBL3818853)
Affinity DataIC50:  0.316nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50255553(CHEMBL4070506)
Affinity DataIC50:  0.398nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50182263(CHEMBL3817901)
Affinity DataIC50:  0.398nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50255503(CHEMBL4066818)
Affinity DataIC50:  0.398nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50255482(CHEMBL4086957)
Affinity DataIC50:  0.398nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50182274(CHEMBL3819163)
Affinity DataIC50:  0.398nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50182276(CHEMBL3818581)
Affinity DataIC50:  0.398nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50173235((S)-2-{4'-[(5-Bromo-4-methoxy-benzofuran-2-carbony...)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM394655(US10308615, Example 12 | preparation of {2-[(pyrid...)
Affinity DataIC50:  0.5nMAssay Description:The vanin-1 protein was prepared in-house from a construct expressing the extracellular domain of human vanin-1 (GenBank ID NM_004666) preceded N-ter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEgl nine homolog 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50385850(CHEMBL2042853)
Affinity DataIC50:  0.501nMAssay Description:Inhibition of PHD2 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50182273(CHEMBL3818827)
Affinity DataIC50:  0.501nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50182272(CHEMBL3818277)
Affinity DataIC50:  0.501nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50182251(CHEMBL3819512)
Affinity DataIC50:  0.501nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50182263(CHEMBL3817901)
Affinity DataIC50:  0.501nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50182265(CHEMBL3819569)
Affinity DataIC50:  0.501nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50255484(CHEMBL4103349)
Affinity DataIC50:  0.501nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50255478(CHEMBL4082031)
Affinity DataIC50:  0.501nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50255541(CHEMBL4088551)
Affinity DataIC50:  0.501nMAssay Description:Antagonist activity at TEV protease cleavage site linked GAL4-VP16-fused recombinant human CXCR2 expressed in cells assessed as inhibition of TEV pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50255540(CHEMBL4066510)
Affinity DataIC50:  0.501nMAssay Description:Antagonist activity at CXCR5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50182269(CHEMBL3818793)
Affinity DataIC50:  0.501nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50182278(CHEMBL3819221)
Affinity DataIC50:  0.501nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50182262(CHEMBL3819295)
Affinity DataIC50:  0.501nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Xwpharma

US Patent
LigandPNGBDBM520674(US11149006, Compound V)
Affinity DataIC50:  0.512nMAssay Description:Experimental procedure for competitive binding (Ki determination): Perform CisBio's Tag-Lite Tachykinin NK-1 binding assay according to manufactu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCollagenase 3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50173236((S)-2-{4'-[(5-Bromo-benzofuran-2-carbonyl)-amino]-...)
Affinity DataIC50:  0.610nMAssay Description:Inhibitory concentration against MMP-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50255481(CHEMBL4098979)
Affinity DataIC50:  0.631nMAssay Description:Agonist activity at CCR8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50255485(CHEMBL4079102)
Affinity DataIC50:  0.631nMAssay Description:Agonist activity at CXCR7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50182264(CHEMBL3818216)
Affinity DataIC50:  0.631nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 2(Homo sapiens (Human))
Gsk Pharmaceuticals R & D

Curated by ChEMBL
LigandPNGBDBM50182255(CHEMBL3818458)
Affinity DataIC50:  0.631nMAssay Description:Antagonist activity at human recombinant Gal4-VP16 fused-CXCR2 assessed as inhibition of CXCL1-mediated lactamase reporter gene expression after over...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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