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Found 405 with Last Name = 'yamane' and Initial = 'y'
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50098965(3-{2-[(Z)-4-Carbamimidoyl-benzoylimino]-3,4-dimeth...)
Affinity DataKi:  0.0460nMAssay Description:Binding to [125I]- fibrinogen by washed platelet fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
University Of Texas M. D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50485562(CHEMBL2074989)
Affinity DataKi:  60nMAssay Description:TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from SR3A cellsMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
University Of Texas M. D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50368352(Cerubidine | DAUNORUBICIN)
Affinity DataKi:  70nMAssay Description:TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from SR3A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
University Of Texas M. D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50485563(CHEMBL2075004)
Affinity DataKi:  120nMAssay Description:TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from SR3A cellsMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
University Of Texas M. D. Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50485564(CHEMBL2075006)
Affinity DataKi:  200nMAssay Description:TP_TRANSPORTER: inhibition of LTC4 uptake in membrane vesicles from SR3A cellsMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50098971(3-({3-Benzyl-2-[(Z)-4-carbamimidoyl-benzoylimino]-...)
Affinity DataIC50:  0.0900nMAssay Description:Affinity for purified activated GPIIb/IIIa fibrinogen receptor in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50098965(3-{2-[(Z)-4-Carbamimidoyl-benzoylimino]-3,4-dimeth...)
Affinity DataIC50:  0.0900nMAssay Description:Affinity for purified activated GPIIb/IIIa fibrinogen receptor in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50098967(3-({2-[(Z)-4-Carbamimidoyl-benzoylimino]-3-ethyl-4...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of immobilized HUVEC adhesion on fibronectinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50098964(3-({3-Butyl-2-[(Z)-4-carbamimidoyl-benzoylimino]-4...)
Affinity DataIC50:  0.130nMAssay Description:Binding to [125I]- fibrinogen by washed platelet fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058752(CHEMBL3335630)
Affinity DataIC50:  0.470nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50098966(3-[3-(4-Carbamimidoyl-benzoylamino)-phenyl]-propio...)
Affinity DataIC50:  0.550nMAssay Description:In vitro inhibition of ADP (2 microM) induced platelet aggregation of human platelet rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50098969(3-[2-(4-Carbamimidoyl-benzoylamino)-4-methyl-thiaz...)
Affinity DataIC50:  0.570nMAssay Description:In vitro inhibition of ADP (3 microM)induced platelet aggregation of guinea pig platelet rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571009(CHEMBL4865592)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571017(CHEMBL4852684)
Affinity DataIC50:  0.760nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571010(CHEMBL4848604)
Affinity DataIC50:  0.810nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571019(CHEMBL4845957)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50098968(3-({2-[(Z)-4-Carbamimidoyl-benzoylimino]-3,4-dimet...)
Affinity DataIC50:  0.890nMAssay Description:Inhibition of immobilized HUVEC adhesion on fibrinogenMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50058757(CHEMBL3335423)
Affinity DataIC50:  0.970nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50098972(3-{2-[(4-Carbamimidoyl-benzoyl)-methyl-amino]-4-me...)
Affinity DataIC50:  1nMAssay Description:Binding to [125I]- fibrinogen by washed platelet fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571012(CHEMBL4867696)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50058753(CHEMBL3335427)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571018(CHEMBL4849679)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571028(CHEMBL4853815)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571952(CHEMBL4858396)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of Axl (unknown origin) by cell free assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571017(CHEMBL4852684)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of recombinant human Axl expressed in mouse BaF3 cells assessed as reduction in cell viability incubated for 2 days by cell titer glo assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571025(CHEMBL4846932)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571020(CHEMBL4867664)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571025(CHEMBL4846932)
Affinity DataIC50:  2nMAssay Description:Inhibition of Axl (unknown origin) by cell free assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571021(CHEMBL4849099)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571016(CHEMBL4864389)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571951(CHEMBL4864780)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of Axl (unknown origin) by cell free assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571011(CHEMBL4865438)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50058754(CHEMBL3335426)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571933(CHEMBL4878216)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of Axl (unknown origin) by cell free assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571953(CHEMBL4860541)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of Axl (unknown origin) by cell free assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571012(CHEMBL4867696)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of recombinant human Axl expressed in mouse BaF3 cells assessed as reduction in cell viability incubated for 2 days by cell titer glo assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50058760(CHEMBL3335421)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571017(CHEMBL4852684)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of recombinant human Mer expressed in mouse BaF3 cells assessed as reduction in cell viability incubated for 2 days by cell titer glo assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50058766(CHEMBL3335415)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571932(CHEMBL4865150)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of Axl (unknown origin) by cell free assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Eisai R&D Management

US Patent
LigandPNGBDBM142338(US8933099, 112)
Affinity DataIC50:  3.40nMT: 2°CAssay Description:In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571945(CHEMBL4866147)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of Axl (unknown origin) by cell free assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571022(CHEMBL4864028)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of recombinant human GST-tagged Axl incubated for 1 hr by ADP-glo based luminometry analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571943(CHEMBL4848465)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of Axl (unknown origin) by cell free assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Eisai R&D Management

US Patent
LigandPNGBDBM142348(US8933099, 114)
Affinity DataIC50:  3.70nMT: 2°CAssay Description:In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571947(CHEMBL4850929)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of Axl (unknown origin) by cell free assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Eisai R&D Management

US Patent
LigandPNGBDBM142347(US8933099, 109)
Affinity DataIC50:  3.90nMT: 2°CAssay Description:In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571933(CHEMBL4878216)
Affinity DataIC50: <4.10nMAssay Description:Inhibition of Mer (unknown origin) by cell free assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571019(CHEMBL4845957)
Affinity DataIC50: <4.10nMAssay Description:Inhibition of recombinant human GST-tagged Mer using biotinylated peptide as substrate incubated for 1 hr by TR-FRET analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
Eisai

Curated by ChEMBL
LigandPNGBDBM50571932(CHEMBL4865150)
Affinity DataIC50: <4.10nMAssay Description:Inhibition of Mer (unknown origin) by cell free assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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