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Found 328 with Last Name = 'yamazaki' and Initial = 't'
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089536(5-[(6,6-Dimethyl-hepta-2,4-diynyl)-methyl-amino]-3...)
Affinity DataIC50:  0.140nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100335(CHEMBL2371681 | RO-09-3655 derivative)
Affinity DataIC50:  0.200nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100338(CHEMBL267407 | RO-09-3655 derivative)
Affinity DataIC50:  0.25nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100332(CHEMBL415843 | RO-09-3655 derivative)
Affinity DataIC50:  0.280nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089557(5-[Butyl-((E)-6,6-dimethyl-hept-2-en-4-ynyl)-amino...)
Affinity DataIC50:  0.350nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
National Institute Of Infectious Diseases

Curated by ChEMBL
LigandPNGBDBM50335557(CHEMBL1652605 | N,N-dipropyl-N'-[4-({[(1H-imidazol...)
Affinity DataIC50:  0.610nMAssay Description:Displacement of [125I]SDF-1alpha form CXCR4 expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100333(CHEMBL2371765 | RO-09-3655 derivative)
Affinity DataIC50:  0.630nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089551(5-[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-propyl-amin...)
Affinity DataIC50:  0.680nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089540(CHEMBL32125 | Phosphoric acid 5-[(6,6-dimethyl-hep...)
Affinity DataIC50:  0.760nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100331(CHEMBL2371715 | RO-09-3655 derivative)
Affinity DataIC50:  0.830nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100329(CHEMBL2371727 | RO-09-3655 derivative)
Affinity DataIC50:  0.890nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100337(CHEMBL2371766 | RO-09-3655 derivative)
Affinity DataIC50:  0.900nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089563(5-[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino...)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089538(5-[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-pentyl-amin...)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089559(5-[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-isopropyl-a...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50366679(CHEMBL1793852 | MK-991)
Affinity DataIC50:  1.30nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100336(CHEMBL405487 | RO-09-3655 derivative)
Affinity DataIC50:  1.40nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108434(US8609688, 12)
Affinity DataIC50:  1.44nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108434(US8609688, 12)
Affinity DataIC50:  1.44nMpH: 8.0 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108430(US8609688, 8)
Affinity DataIC50:  1.5nMpH: 8.0 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108430(US8609688, 8)
Affinity DataIC50:  1.5nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108428(US8609688, 6)
Affinity DataIC50:  1.63nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108428(US8609688, 6)
Affinity DataIC50:  1.63nMpH: 8.0 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108426(US8609688, 4)
Affinity DataIC50:  1.70nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108426(US8609688, 4)
Affinity DataIC50:  1.70nMpH: 8.0 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108440(US8609688, 18)
Affinity DataIC50:  1.79nMpH: 8.0 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108440(US8609688, 18)
Affinity DataIC50:  1.79nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50222422(6,7-diethoxy-4-(2-(3-(4-fluorophenyl)-1H-pyrazol-4...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of partially purified EGFR tyrosine kinase from human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108436(US8609688, 14)
Affinity DataIC50:  1.84nMpH: 8.0 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108436(US8609688, 14)
Affinity DataIC50:  1.84nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50096797(CHEMBL2370665 | macrocyclic lipopeptidolactone der...)
Affinity DataIC50:  2nMAssay Description:Inhibition of 1,3-beta-D-glucan synthase (GS) from candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108435(US8609688, 13)
Affinity DataIC50:  2.15nMpH: 8.0 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108435(US8609688, 13)
Affinity DataIC50:  2.15nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108429(US8609688, 7)
Affinity DataIC50:  2.45nMpH: 8.0 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108429(US8609688, 7)
Affinity DataIC50:  2.45nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108431(US8609688, 9)
Affinity DataIC50:  2.51nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108431(US8609688, 9)
Affinity DataIC50:  2.51nMpH: 8.0 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetC-X-C chemokine receptor type 4(Homo sapiens (Human))
National Institute Of Infectious Diseases

Curated by ChEMBL
LigandPNGBDBM50335557(CHEMBL1652605 | N,N-dipropyl-N'-[4-({[(1H-imidazol...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of Mab 12G5 binding to wild type CXCR4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089543(5-[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-amin...)
Affinity DataIC50:  2.80nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Mitsubishi Pharma

Curated by ChEMBL
LigandPNGBDBM50222428((R)-4-(6,7-dimethoxyquinazolin-4-yl)-N,N-diethyl-2...)
Affinity DataIC50:  3nMAssay Description:Inhibition of partially purified EGFR tyrosine kinase from human A431 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50495787(CHEMBL3114956)
Affinity DataIC50:  3nMAssay Description:Inhibition of full-length human PDE4B2 assessed as cAMP hydrolysis preincubated for 20 mins followed by cAMP addition measured after 30 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089547(5-[(6,6-Dimethyl-hepta-2,4-diynyl)-methyl-amino]-3...)
Affinity DataIC50:  3nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108425(US8609688, 3)
Affinity DataIC50:  3.09nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108425(US8609688, 3)
Affinity DataIC50:  3.09nMpH: 8.0 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108433(US8609688, 11)
Affinity DataIC50:  3.36nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108433(US8609688, 11)
Affinity DataIC50:  3.36nMpH: 8.0 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108438(US8609688, 16)
Affinity DataIC50:  3.42nMpH: 8.0 T: 2°CAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen™ (Amplified Lum...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108438(US8609688, 16)
Affinity DataIC50:  3.42nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50100334(CHEMBL407924 | RO-09-3655 derivative)
Affinity DataIC50:  3.60nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Arqule

US Patent
LigandPNGBDBM108441(US8609688, 19)
Affinity DataIC50:  3.77nMAssay Description:AKT1 activity was assayed using the GSK3-derived biotinylated peptide substrate, crosstide (biotin-GRPRTSSFAEG), and AlphaScreen (Amplified Luminesce...More data for this Ligand-Target Pair
In DepthDetails US Patent
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