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Found 75 with Last Name = 'zeller' and Initial = 'j'
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239773(CHEMBL492244)
Affinity DataIC50:  5nMAssay Description:Inhibition of human N-terminal GST/His6-tagged GSK3beta (M1 to T420 residues) expressed in baculovirus infected sf9 cells using RBER-IRStide as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239780(CHEMBL4065365)
Affinity DataIC50:  43nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinE expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239778(CHEMBL1830064)
Affinity DataIC50:  54nMAssay Description:Inhibition of compound against thymidylate synthetaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50005337(CHEMBL1276317)
Affinity DataIC50:  75nMAssay Description:Inhibition of compound against Guanine-7-methyl transferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239778(CHEMBL1830064)
Affinity DataIC50:  90nMAssay Description:Inhibition of recombinant GSK3beta (unknown origin) after 10 mins in presence of [gamma32P]ATP by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239776(CHEMBL4085289)
Affinity DataIC50:  90nMAssay Description:Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239776(CHEMBL4085289)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant GSK3beta (unknown origin) after 10 mins in presence of [gamma32P]ATP by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50005337(CHEMBL1276317)
Affinity DataIC50:  110nMAssay Description:Inhibition of recombinant GSK3beta (unknown origin) after 10 mins in presence of [gamma32P]ATP by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Sptanis Pharmachem Consulting

Curated by ChEMBL
LigandPNGBDBM50030474(Avandamet | Avandaryl | Avandia | BRL-49653 | CHEB...)
Affinity DataIC50:  112nMAssay Description:Competitive displacement of fluorescently labelled PPAR tracer ligand from GST-tagged human PPARgamma ligand binding domain after 1 hr in dark by TR-...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Sptanis Pharmachem Consulting

Curated by ChEMBL
LigandPNGBDBM50150998(((4-Methoxy-phenoxycarbonyl)-{4-[2-(5-methyl-2-phe...)
Affinity DataIC50:  120nMAssay Description:Competitive displacement of fluorescently labelled PPAR tracer ligand from GST-tagged human PPARgamma ligand binding domain after 1 hr in dark by TR-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239778(CHEMBL1830064)
Affinity DataIC50:  160nMAssay Description:Inhibition of full length human N-terminal His6-tagged CDK6/N-terminal GST-tagged CyclinD3 expressed in sf21 cells after 10 mins in presence of [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239774(CHEMBL4084775)
Affinity DataIC50:  169nMAssay Description:Inhibition of IGF1R (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239778(CHEMBL1830064)
Affinity DataIC50:  210nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinA expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50005337(CHEMBL1276317)
Affinity DataIC50:  210nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinE expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239779(CHEMBL1802727)
Affinity DataIC50:  230nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinE expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239777(CHEMBL4100748)
Affinity DataIC50:  290nMAssay Description:Inhibition of recombinant GSK3beta (unknown origin) after 10 mins in presence of [gamma32P]ATP by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239773(CHEMBL492244)
Affinity DataIC50:  300nMAssay Description:Displacement of [125 I] CCK-8 from Cholecystokinin type B receptor of guinea pig cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCatenin beta-1/Transcription factor 7-like 2(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM40314(3-(4-Chloro-phenyl)-1,6-dimethyl-1H-pyrimido[5,4-e...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human TCF4/ flag epitope-tagged beta-catenin (unknown origin) interaction transfected in human HCT116 cells after 24 hrs by beta-galact...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Sptanis Pharmachem Consulting

Curated by ChEMBL
LigandPNGBDBM50085045(5-((4-((6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-...)
Affinity DataIC50:  370nMAssay Description:Competitive displacement of fluorescently labelled PPAR tracer ligand from GST-tagged human PPARgamma ligand binding domain after 1 hr in dark by TR-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239776(CHEMBL4085289)
Affinity DataIC50:  410nMAssay Description:Inhibition of full length human N-terminal His6-tagged CDK6/N-terminal GST-tagged CyclinD3 expressed in sf21 cells after 10 mins in presence of [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239773(CHEMBL492244)
Affinity DataIC50:  500nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged CDK5 (M1 to P292 residues)/p35NCK (M1 to R307 residues) expressed in baculovirus infected sf9 c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50005337(CHEMBL1276317)
Affinity DataIC50:  540nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinA expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
Affinity DataIC50:  600nMAssay Description:Inhibition of recombinant GSK3beta (unknown origin) after 10 mins in presence of [gamma32P]ATP by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Affinity DataIC50:  620nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinE expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239775(CHEMBL4100916)
Affinity DataIC50:  810nMAssay Description:Inhibition of recombinant GSK3beta (unknown origin) after 10 mins in presence of [gamma32P]ATP by beta counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239776(CHEMBL4085289)
Affinity DataIC50:  840nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinA expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239778(CHEMBL1830064)
Affinity DataIC50:  910nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK1/N-terminal GST-tagged CyclinB expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239777(CHEMBL4100748)
Affinity DataIC50:  920nMAssay Description:Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitochondrial pyruvate carrier 2(Homo sapiens)
Sptanis Pharmachem Consulting

Curated by ChEMBL
LigandPNGBDBM50466687(CHEMBL4291468)
Affinity DataIC50:  1.20E+3nMAssay Description:Displacement of photoprobe from MPC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitochondrial pyruvate carrier 2(Homo sapiens)
Sptanis Pharmachem Consulting

Curated by ChEMBL
LigandPNGBDBM228129(US9562012, mitoglitazone)
Affinity DataIC50:  1.20E+3nMAssay Description:Displacement of photoprobe from MPC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239775(CHEMBL4100916)
Affinity DataIC50:  1.35E+3nMAssay Description:Inhibition of full length human N-terminal His6-tagged CDK6/N-terminal GST-tagged CyclinD3 expressed in sf21 cells after 10 mins in presence of [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239777(CHEMBL4100748)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of full length human N-terminal His6-tagged CDK6/N-terminal GST-tagged CyclinD3 expressed in sf21 cells after 10 mins in presence of [gamm...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50005337(CHEMBL1276317)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK1/N-terminal GST-tagged CyclinB expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239775(CHEMBL4100916)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinE expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Sptanis Pharmachem Consulting

Curated by ChEMBL
LigandPNGBDBM50103521(Actos | CHEBI:8228 | Duetact | Pioglitazone | US10...)
Affinity DataIC50:  1.79E+3nMAssay Description:Competitive displacement of fluorescently labelled PPAR tracer ligand from GST-tagged human PPARgamma ligand binding domain after 1 hr in dark by TR-...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of CDK2/CyclinE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinA expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Sptanis Pharmachem Consulting

Curated by ChEMBL
LigandPNGBDBM50466688(CHEMBL4276678)
Affinity DataIC50:  2.32E+3nMAssay Description:Competitive displacement of fluorescently labelled PPAR tracer ligand from GST-tagged human PPARgamma ligand binding domain after 1 hr in dark by TR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Sptanis Pharmachem Consulting

Curated by ChEMBL
LigandPNGBDBM50466690(CHEMBL4293295)
Affinity DataIC50:  3.12E+3nMAssay Description:Competitive displacement of fluorescently labelled PPAR tracer ligand from GST-tagged human PPARgamma ligand binding domain after 1 hr in dark by TR-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Affinity DataIC50:  3.49E+3nMAssay Description:Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Sptanis Pharmachem Consulting

Curated by ChEMBL
LigandPNGBDBM50103636(ADD-3878 | CHEBI:64227 | Ciglitazone | U-63287)
Affinity DataIC50: >5.00E+3nMAssay Description:Competitive displacement of fluorescently labelled PPAR tracer ligand from GST-tagged human PPARgamma ligand binding domain after 1 hr in dark by TR-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of IGF1R (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
Affinity DataIC50:  5.50E+3nMAssay Description:Displacement of 125 I-gastrin from gastrin receptor of guinea pig gastric glandsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239776(CHEMBL4085289)
Affinity DataIC50:  5.58E+3nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK1/N-terminal GST-tagged CyclinB expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Sptanis Pharmachem Consulting

Curated by ChEMBL
LigandPNGBDBM50466687(CHEMBL4291468)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinE expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM7392(2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of CDK2/CyclinA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Affinity DataIC50:  7.89E+3nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK1/N-terminal GST-tagged CyclinB expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Sptanis Pharmachem Consulting

Curated by ChEMBL
LigandPNGBDBM50466693(CHEMBL4288064)
Affinity DataIC50:  8.46E+3nMAssay Description:Competitive displacement of fluorescently labelled PPAR tracer ligand from GST-tagged human PPARgamma ligand binding domain after 1 hr in dark by TR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University of Kaiserslautern

Curated by ChEMBL
LigandPNGBDBM50239777(CHEMBL4100748)
Affinity DataIC50:  9.30E+3nMAssay Description:Inhibition of full length human C-terminal His6-tagged CDK2/N-terminal GST-tagged CyclinA expressed in baculovirus infected sf21 cells after 10 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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