BindingDB PrimarySearch_ki

Found 2387 with Last Name = 'zhu' and Initial = 't'

Serine/threonine-protein kinase B-raf(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL

PNG

BDBM50029085(CHEBI:83405 | CHEMBL525191 | GDC-0879)

Ki: 0.130nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL MCE
PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Mu-type opioid receptor(Homo sapiens (Human))TBA

PNG

BDBM50001019(6,11-Dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,...)

Ki: 0.200nMAssay Description:Binding affinity to mu opioid receptor (unknown origin) assessed as inhibition constant in presence of LevorphanolMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid Similars

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50001019(6,11-Dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,...)

Ki: 0.200nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes by microbeta scintillation counting methodMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid Similars

Mu-type opioid receptor(Rattus norvegicus (rat))
Huazhong University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50581486(CHEMBL5082165)

Ki: 0.220nMAssay Description:Displacement of [3H]DAMGO from MOR in Sprague-Dawley rat brain membranes measured after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Mu-type opioid receptor(Rattus norvegicus (rat))
Huazhong University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50581505(CHEMBL5094445)

Ki: 1.10nMAssay Description:Displacement of [3H]DAMGO from MOR in Sprague-Dawley rat brain membranes measured after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50038419(CHEMBL50112 | N-(1-Benzyl-piperidin-4-yl)-4-iodo-b...)

Ki: 1.70nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes by microbeta scintillation counting methodMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL MCE
PC cid PC sid PDB Patents Similars

Details PubMed PDB

3D Structure (crystal)

Mu-type opioid receptor(Homo sapiens (Human))TBA

PNG

BDBM50564193(CHEMBL4789321)

Ki: 1.90nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHO-K1 cell membranes incubated for 90 mins measured by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase PC cid PC sid

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50564193(CHEMBL4789321)

Ki: 2.10nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes by microbeta scintillation counting methodMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase PC cid PC sid

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50590791(CHEMBL5192526)

Ki: 2.80nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes by microbeta scintillation counting methodMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Mu-type opioid receptor(Homo sapiens (Human))TBA

PNG

BDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)

Ki: 3.20nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHO-K1 cell membranes incubated for 90 mins measured by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL KEGG PC cid PC sid Similars

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50590778(CHEMBL5182393)

Ki: 3.30nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes by microbeta scintillation counting methodMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Mu-type opioid receptor(Homo sapiens (Human))TBA

PNG

BDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)

Ki: 3.30nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHO-K1 cell membranes incubated for 90 mins measured by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank PC cid PC sid PDB Patents Similars

Details PubMed DrugBank
PDB

3D Structure (crystal)

Mu-type opioid receptor(Rattus norvegicus (rat))
Huazhong University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50581499(CHEMBL5086596)

Ki: 3.30nMAssay Description:Displacement of [3H]DAMGO from MOR in Sprague-Dawley rat brain membranes measured after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Mu-type opioid receptor(Rattus norvegicus (rat))
Huazhong University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50564175(CHEMBL4788719)

Ki: 3.70nMAssay Description:Displacement of [3H]DAMGO from MOR in Sprague-Dawley rat brain membranes measured after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Mu-type opioid receptor(Rattus norvegicus (rat))
Huazhong University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50581497(CHEMBL5075339)

Ki: 3.70nMAssay Description:Displacement of [3H]DAMGO from MOR in Sprague-Dawley rat brain membranes measured after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50001043(6,11-Dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,...)

Ki: 3.90nMAssay Description:Displacement of [3H]pentazocine from guinea pig brain membrane sigma 1 receptor incubated for 120 minsMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL PC cid PC sid Similars

Mu-type opioid receptor(Homo sapiens (Human))TBA

PNG

BDBM50001043(6,11-Dimethyl-3-phenethyl-1,2,3,4,5,6-hexahydro-2,...)

Ki: 3.90nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHO-K1 cell membranes incubated for 90 mins measured by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid Similars

Mu-type opioid receptor(Rattus norvegicus (rat))
Huazhong University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50581508(CHEMBL5087973)

Ki: 4.30nMAssay Description:Displacement of [3H]DAMGO from MOR in Sprague-Dawley rat brain membranes measured after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50581508(CHEMBL5087973)

Ki: 4.30nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes by microbeta scintillation counting methodMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Mu-type opioid receptor(Rattus norvegicus (rat))
Huazhong University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50581498(CHEMBL5079619)

Ki: 4.40nMAssay Description:Displacement of [3H]DAMGO from MOR in Sprague-Dawley rat brain membranes measured after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Mu-type opioid receptor(Rattus norvegicus (rat))
Huazhong University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50581496(CHEMBL5087044)

Ki: 5nMAssay Description:Displacement of [3H]DAMGO from MOR in Sprague-Dawley rat brain membranes measured after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50581498(CHEMBL5079619)

Ki: 5.5nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in guinea pig brain membranes incubated for 90 mins by liquid scintillation counting metho...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50064196((2S,6R,11S)-6,11-Dimethyl-3-[2-(methyl-phenyl-amin...)

Ki: 5.60nMAssay Description:Displacement of [3H]pentazocine from guinea pig brain membrane sigma 1 receptor incubated for 150 minsMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50064195((2S,6R,11S)-6,11-Dimethyl-3-(2-phenylamino-ethyl)-...)

Ki: 5.90nMAssay Description:Displacement of [3H]pentazocine from guinea pig brain membrane sigma 1 receptor incubated for 150 minsMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Mu-type opioid receptor(Rattus norvegicus (rat))
Huazhong University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50581501(CHEMBL5094800)

Ki: 6.10nMAssay Description:Displacement of [3H]DAMGO from MOR in Sprague-Dawley rat brain membranes measured after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Mu-type opioid receptor(Homo sapiens (Human))TBA

PNG

BDBM50590799(CHEMBL5179132)

Ki: 6.5nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHO-K1 cell membranes incubated for 90 mins measured by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50396352(CHEMBL2170062)

Ki: 6.5nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes by microbeta scintillation counting methodMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase CHEMBL MCE
PC cid PC sid PDB Similars

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50590780(CHEMBL5188409)

Ki: 7.30nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes by microbeta scintillation counting methodMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Mu-type opioid receptor(Homo sapiens (Human))TBA

PNG

BDBM50590796(CHEMBL5183712)

Ki: 7.90nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHO-K1 cell membranes incubated for 90 mins measured by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Mu-type opioid receptor(Rattus norvegicus (rat))
Huazhong University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50581484(CHEMBL5094951)

Ki: 9.40nMAssay Description:Displacement of [3H]DAMGO from MOR in Sprague-Dawley rat brain membranes measured after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Mu-type opioid receptor(Homo sapiens (Human))TBA

PNG

BDBM50590809(CHEMBL5181954)

Ki: 12nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHO-K1 cell membranes incubated for 90 mins measured by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Mu-type opioid receptor(Homo sapiens (Human))TBA

PNG

BDBM50590800(CHEMBL5179531)

Ki: 15nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHO-K1 cell membranes incubated for 90 mins measured by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50581484(CHEMBL5094951)

Ki: 16nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in guinea pig brain membranes incubated for 90 mins by liquid scintillation counting metho...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Mu-type opioid receptor(Homo sapiens (Human))TBA

PNG

BDBM50590790(CHEMBL5208537)

Ki: 17nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHO-K1 cell membranes incubated for 90 mins measured by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Mu-type opioid receptor(Homo sapiens (Human))TBA

PNG

BDBM50581508(CHEMBL5087973)

Ki: 19nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHO-K1 cell membranes incubated for 90 mins measured by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Mu-type opioid receptor(Homo sapiens (Human))TBA

PNG

BDBM50590811(CHEMBL5195239)

Ki: 19nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHO-K1 cell membranes incubated for 90 mins measured by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50581508(CHEMBL5087973)

Ki: 19nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in guinea pig brain membranes incubated for 90 mins by liquid scintillation counting metho...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50590786(CHEMBL5202810)

Ki: 20nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes by microbeta scintillation counting methodMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Mu-type opioid receptor(Rattus norvegicus (rat))
Huazhong University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50581485(CHEMBL5082953)

Ki: 21nMAssay Description:Displacement of [3H]DAMGO from MOR in Sprague-Dawley rat brain membranes measured after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Mu-type opioid receptor(Homo sapiens (Human))TBA

PNG

BDBM50590795(CHEMBL5174391)

Ki: 22nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHO-K1 cell membranes incubated for 90 mins measured by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50581506(CHEMBL5078411)

Ki: 23nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma-1 receptor in guinea pig brain membranes incubated for 90 mins by liquid scintillation counting metho...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50590777(CHEMBL5198980)

Ki: 23nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes by microbeta scintillation counting methodMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50590782(CHEMBL5208375)

Ki: 24nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes by microbeta scintillation counting methodMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50590795(CHEMBL5174391)

Ki: 24nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes by microbeta scintillation counting methodMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Mu-type opioid receptor(Homo sapiens (Human))TBA

PNG

BDBM50590804(CHEMBL5179109)

Ki: 27nMAssay Description:Displacement of [3H]-DAMGO from human MOR expressed in CHO-K1 cell membranes incubated for 90 mins measured by MicroBeta scintillation counter methodMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Mu-type opioid receptor(Rattus norvegicus (rat))
Huazhong University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50581487(CHEMBL5093427)

Ki: 27nMAssay Description:Displacement of [3H]DAMGO from MOR in Sprague-Dawley rat brain membranes measured after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50590779(CHEMBL5186423)

Ki: 28nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes by microbeta scintillation counting methodMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Mu-type opioid receptor(Rattus norvegicus (rat))
Huazhong University Of Science And Technology

Curated by ChEMBL

PNG

BDBM50064196((2S,6R,11S)-6,11-Dimethyl-3-[2-(methyl-phenyl-amin...)

Ki: 29nMAssay Description:Displacement of [ 3H]-naloxone from rat brain membrane mu opioid receptorMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50590793(CHEMBL5187961)

Ki: 29nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes by microbeta scintillation counting methodMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Sigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Jiangsu Ocean University

Curated by ChEMBL

PNG

BDBM50590781(CHEMBL5182504)

Ki: 29nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in guinea pig brain membranes by microbeta scintillation counting methodMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Displayed 1 to 50 (of 2387 total ) | Next | Last >>

Filter my 2387 hits

Targets 70▿
- Activin receptor type-1 [172-499] 352
- Serine/threonine-protein kinase receptor R3 [166-493] 176
- Activin receptor type-1 [172-499,R206H] 176
- Bone morphogenetic protein receptor type-1A [198-525] 176
- Bone morphogenetic protein receptor type-1B 176
- TGF-beta receptor type-1 [162-503] 176
- Epidermal growth factor receptor 119
- Mu-type opioid receptor 118
- Sigma non-opioid intracellular receptor 1 98
- RAF proto-oncogene serine/threonine-protein kinase 94
- Receptor tyrosine-protein kinase erbB-4 67
- Receptor tyrosine-protein kinase erbB-2 58
- Cyclin-A2/Cyclin-dependent kinase 2 47
- Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C] 47
- Tyrosine-protein kinase JAK3 40
- Leucine-rich repeat serine/threonine-protein kinase 2 [G2019S] 38
- Serine/threonine-protein kinase Nek2 26
- Receptor-type tyrosine-protein kinase FLT3 24
- Sodium/glucose cotransporter 2 24
- Potassium voltage-gated channel subfamily H member 2 24
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 21
- Melanocortin receptor 4 21
- Melanocortin receptor 3 21
- Melanocyte-stimulating hormone receptor 21
- Tyrosine-protein phosphatase non-receptor type 1 20
- Serine/threonine-protein kinase pim-1 20
- Sodium/glucose cotransporter 1 20
- Melanocortin receptor 5 20
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 19
- Steroid hormone receptor ERR1 16
- ALK tyrosine kinase receptor 15
- Insulin receptor 15
- Isoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10) 10
- ALK tyrosine kinase receptor/Nucleophosmin 8
- Amine oxidase [flavin-containing] A 7
- Solute carrier family 5 member 4 7
- Serine/threonine-protein kinase mTOR 6
- Tyrosine-protein kinase ABL1 5
- Proto-oncogene tyrosine-protein kinase Src 5
- Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 4
- Hemagglutinin 4
- Insulin-like growth factor 1 receptor 4
- Aurora kinase A 4
- Sigma intracellular receptor 2 3
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform 2
- DNA topoisomerase 2-alpha 2
- Tyrosine-protein phosphatase non-receptor type 6 2
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform 2
- Reverse transcriptase 2
- Neuraminidase 2
- Tyrosine-protein phosphatase non-receptor type 2 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2
- Tubulin beta chain 2
- Tyrosine-protein kinase Lck 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1
- Cyclin-dependent kinase 4 1
- RAC-alpha serine/threonine-protein kinase 1
- Cyclin-dependent kinase 2 1
- Ribosomal protein S6 kinase alpha-1 1
- Cytochrome P450 1A2 1
- Serine/threonine-protein kinase Chk1 1
- NEDD8-activating enzyme E1 regulatory subunit 1
- MAP kinase-activated protein kinase 2 1
- Cytochrome P450 2C9 1
- Mitogen-activated protein kinase 14 1
- Carbonic anhydrase 9 1
- Cytochrome P450 2C19 1
- Serine/threonine-protein kinase B-raf 1
- Cytochrome P450 2D6 1
- Glycogen synthase kinase-3 beta 1
- ...
Publications 29▿
- US Patent US10710980 (2020) 616
- US Patent US10947218 (2021) 616
- J Med Chem 59: 8103-24 (2016) 286
- Eur J Med Chem 241: (2022) 101
- J Med Chem 48: 2388-406 (2005) 94
- J Med Chem 65: 4007-4017 (2022) 83
- Eur J Med Chem 226: (2021) 72
- US Patent US11597733 (2023) 60
- J Med Chem 49: 1006-15 (2006) 58
- Eur J Med Chem 44: 1240-9 (2009) 51
- Bioorg Med Chem Lett 18: 2346-50 (2008) 43
- Eur J Med Chem 126: 1083-1106 (2017) 41
- US Patent US20230391775 (2023) 38
- Bioorg Med Chem Lett 20: 1569-72 (2010) 36
- J Med Chem 63: 3028-3046 (2020) 27
- J Med Chem 56: 2779-90 (2013) 26
- Bioorg Med Chem Lett 17: 2150-5 (2007) 24
- Bioorg Med Chem Lett 27: 1105-1108 (2017) 24
- J Med Chem 54: 2952-60 (2011) 15
- J Med Chem 50: 5886-9 (2007) 11
- J Nat Prod 74: 547-53 (2011) 4
- J Med Chem 63: 6924-6940 (2020) 4
- Eur J Med Chem 68: 58-71 (2013) 2
- Eur J Med Chem 238: (2022) 2
- J Nat Prod 76: 2298-306 (2013) 2
- Bioorg Med Chem Lett 23: 1776-8 (2013) 2
- Eur J Med Chem 183: (2019) 1
- Bioorg Med Chem 22: 6201-8 (2014) 1
- Bioorg Med Chem Lett 30: (2020) 1
Institutions 16▿
- Novartis 1292
- University Of Auckland 286
- Pfizer 180
- Jiangsu Ocean University 101
- China Pharmaceutical University 94
- East China Normal University 92
- Universit£ 83
- Huazhong University Of Science And Technology 72
- Chembridge Research Laboratories And Chembridge 58
- Suzhou Yabao Pharmaceutical R&D Co. 38
- University Of Kansas Medical Center 26
- Ocean University Of China 8
- Wyeth Research 4
- Zhengzhou University 4
- Sun Yat-Sen University 2
- Nanjing University 1
Affinity: 0.11 to 9.0E+5 nM▿
- Ki 246
- IC50 2033
- Kd 64
- EC50 44
- Affinity ≤ nM
Xtal structures: 14
Docked structures: 1
Catalog Cmpds: 64