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Found 42 with Last Name = 'van boom' and Initial = 'jh'
TargetAsialoglycoprotein receptor 1(Mus musculus)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50074090(CHEMBL2368210 | Galactoside analogue)
Affinity DataKi:  93nMAssay Description:Affinity tested by in vitro competition assay of [125I]ASOR binding to parenchymal rat liver cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAsialoglycoprotein receptor 1(Mus musculus)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50074091(CHEMBL2368208 | Galactoside analogue)
Affinity DataKi:  93nMAssay Description:Affinity tested by in vitro competition assay of [125I]ASOR binding to parenchymal rat liver cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAsialoglycoprotein receptor 1(Mus musculus)
Leiden University

Curated by ChEMBL
LigandPNGBDBM50074089(CHEMBL2368207 | TG(20)C-Galactoside analogue)
Affinity DataKi:  200nMAssay Description:Affinity tested by in vitro competition assay of [125I]ASOR binding to parenchymal rat liver cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290252(CHEMBL78510 | potassium; (3E,7E)-4,8,12-trimethyl-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of Squalene SynthaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50150667((S)-2-({(2S,3S,6R)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  250nMAssay Description:Inhibition of [3H]FPP incorporation by Protein FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50450929(CHEMBL2029143 | CHEMBL3142450)
Affinity DataIC50:  350nMAssay Description:In vitro anti-thrombin activity was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50122992(CHEMBL2370448 | [(1R,15S,16R,17S)-11-(3-Guanidino-...)
Affinity DataIC50:  384nMAssay Description:Displacement of [125I]-echistatin from alphaIIb-beta3 integrin of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50366346(CHEMBL1790477)
Affinity DataIC50:  420nMAssay Description:Inhibition of [3H]FPP incorporation by Protein FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAntithrombin-III(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50037996(1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimido...)
Affinity DataIC50:  570nMAssay Description:Antithrombin III (ATIII)-mediated anti-Xa activity was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290254(CHEMBL80021 | pentapotassium ({[(3E,7E)-4,8,12-tri...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of Squalene SynthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50122992(CHEMBL2370448 | [(1R,15S,16R,17S)-11-(3-Guanidino-...)
Affinity DataIC50:  1.49E+3nMAssay Description:Displacement of [125I]-echistatin from alphaV-beta3 integrin of human skin fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50290254(CHEMBL80021 | pentapotassium ({[(3E,7E)-4,8,12-tri...)
Affinity DataIC50:  1.81E+3nMAssay Description:Inhibition of Farnesyl TransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50150666((S)-2-({(2S,3S,6R)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of [3H]FPP incorporation by Protein FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50290253(CHEMBL21986 | pentapotassium ({[(6E,10E,15E,19E)-2...)
Affinity DataIC50:  3.99E+3nMAssay Description:Inhibition of Farnesyl TransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50290252(CHEMBL78510 | potassium; (3E,7E)-4,8,12-trimethyl-...)
Affinity DataIC50:  1.35E+4nMAssay Description:Inhibition of Farnesyl TransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50150662((S)-2-({(2S,3S,6R)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  1.40E+4nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290253(CHEMBL21986 | pentapotassium ({[(6E,10E,15E,19E)-2...)
Affinity DataIC50:  2.33E+4nMAssay Description:Inhibition of Squalene SynthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50122993(CHEMBL2370452 | [(1R,18S,19R,20S)-14-(3-Guanidino-...)
Affinity DataIC50:  3.22E+4nMAssay Description:Displacement of [125I]-echistatin from alphaIIb-beta3 integrin of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50290251(CHEMBL79827 | tripotassium 2,4,6-trioxo-3-[(2E,6E)...)
Affinity DataIC50:  3.42E+4nMAssay Description:Inhibition of Farnesyl TransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50150665((S)-2-({(2S,3S,6S)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of [3H]FPP incorporation by Protein FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290251(CHEMBL79827 | tripotassium 2,4,6-trioxo-3-[(2E,6E)...)
Affinity DataIC50:  4.64E+4nMAssay Description:Inhibition of Squalene SynthaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50150665((S)-2-({(2S,3S,6S)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290250(CHEMBL81657 | tripotassium 2,4,6-trioxo-3,3-bis[(2...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of Squalene SynthaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50290250(CHEMBL81657 | tripotassium 2,4,6-trioxo-3,3-bis[(2...)
Affinity DataIC50:  5.62E+4nMAssay Description:Inhibition of Farnesyl TransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50150662((S)-2-({(2S,3S,6R)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  5.70E+4nMAssay Description:Inhibition of [3H]FPP incorporation by Protein FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150664((S)-2-({(2S,3S,6S)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  9.10E+4nMAssay Description:Inhibition of [3H]FPP incorporation by Protein FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50122993(CHEMBL2370452 | [(1R,18S,19R,20S)-14-(3-Guanidino-...)
Affinity DataIC50:  9.81E+4nMAssay Description:Displacement of [125I]-echistatin from alphaV-beta3 integrin of human skin fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50122991(CHEMBL113277 | [(1R,6S,7R,8S,9R,23S,24R,25S)-19-(3...)
Affinity DataIC50:  1.98E+5nMAssay Description:Displacement of [125I]-echistatin from alphaIIb-beta3 integrin of human plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150663((S)-2-({(2S,3S,6S)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  2.06E+5nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150671((S)-2-(1-{(2R,6R)-6-[((R)-2-Amino-3-tert-butyldisu...)
Affinity DataIC50:  2.61E+5nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150669((S)-2-(1-{(2R,3S,6S)-6-[((R)-2-Amino-3-tert-butyld...)
Affinity DataIC50:  2.70E+5nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150668((S)-2-(1-{(2R,3S,6S)-6-[((R)-2-Amino-3-tert-butyld...)
Affinity DataIC50:  3.11E+5nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150663((S)-2-({(2S,3S,6S)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  3.21E+5nMAssay Description:Inhibition of [3H]FPP incorporation by Protein FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150670((S)-2-(1-{(2R,3S,6R)-6-[((R)-2-Amino-3-tert-butyld...)
Affinity DataIC50:  4.64E+5nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150672((S)-2-(1-{(2R,3S,6R)-6-[((R)-2-Amino-3-tert-butyld...)
Affinity DataIC50:  5.00E+5nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150664((S)-2-({(2S,3S,6S)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50:  5.21E+5nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50122991(CHEMBL113277 | [(1R,6S,7R,8S,9R,23S,24R,25S)-19-(3...)
Affinity DataIC50:  5.97E+5nMAssay Description:Displacement of [125I]-echistatin from alphaV-beta3 integrin of human skin fibroblastsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150672((S)-2-(1-{(2R,3S,6R)-6-[((R)-2-Amino-3-tert-butyld...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of [3H]FPP incorporation by Protein FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150666((S)-2-({(2S,3S,6R)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150671((S)-2-(1-{(2R,6R)-6-[((R)-2-Amino-3-tert-butyldisu...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of [3H]FPP incorporation by Protein FarnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50150667((S)-2-({(2S,3S,6R)-6-[((R)-2-Amino-3-tert-butyldis...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of [3H]GGPP incorporation by Protein Geranylgeranyl transferase type IMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Gorlaeus Laboratories

Curated by ChEMBL
LigandPNGBDBM50037996(1-[N-(naphthalen-2-ylsulfonyl)glycyl-4-carbamimido...)
Affinity DataEC50:  750nMAssay Description:Effective concentration against thrombin was determinedMore data for this Ligand-Target Pair