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Found 179 with Last Name = 'van poelje' and Initial = 'pd'
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataKi:  0.220nMAssay Description:Displacement of [125I]T3 from recombinant thyroid hormone receptor alpha (unknown origin) expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM18869(2-{3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenox...)
Affinity DataKi:  0.370nMAssay Description:Displacement of [125I]T3 from recombinant thyroid hormone receptor beta (unknown origin) expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataKi:  0.550nMAssay Description:Displacement of [125I]T3 from recombinant thyroid hormone receptor beta (unknown origin) expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50242403((3,5-dimethyl-4-(4-hydroxy-3-isopropylbenzyl)pheno...)
Affinity DataKi:  2.17nMAssay Description:Displacement of [125I]T3 from recombinant thyroid hormone receptor beta (unknown origin) expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM18869(2-{3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenox...)
Affinity DataKi:  7.18nMAssay Description:Displacement of [125I]T3 from recombinant thyroid hormone receptor alpha (unknown origin) expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50242403((3,5-dimethyl-4-(4-hydroxy-3-isopropylbenzyl)pheno...)
Affinity DataKi:  35.2nMAssay Description:Displacement of [125I]T3 from recombinant thyroid hormone receptor alpha (unknown origin) expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50242404((4S)-4-(3-chlorophenyl)-2-[(3,5-dimethyl-4-(4-hydr...)
Affinity DataKi:  1.25E+4nMAssay Description:Displacement of [125I]T3 from recombinant thyroid hormone receptor alpha (unknown origin) expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50242404((4S)-4-(3-chlorophenyl)-2-[(3,5-dimethyl-4-(4-hydr...)
Affinity DataKi:  1.46E+4nMAssay Description:Displacement of [125I]T3 from recombinant thyroid hormone receptor beta (unknown origin) expressed in sf9 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50293594(5-(2-amino-5-isobutylthiazol-4-yl)furan-2-ylphosph...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303854(5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303879(4-Amino-5-fluoro-7-[3-(N,N-dimethylamino)propyl]-1...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303863(4-Amino-5-fluoro-1-cyclopropylmethyl-2-[5-(2-phosp...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303871(4-Amino-7-cyclopropyl-5-fluoro-1-isobutyl-2-[5-(2-...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303880(4-Amino-5-fluoro-7-(4-chlorobutyl)-1-isobutyl-2-[5...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303878(4-Amino-7-(3-hydroxypropyl)-5-fluoro-1-isobutyl-2-...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303872(4-Amino-7-phenyl-5-fluoro-1-isobutyl-2-[5-(2-phosp...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303874(4-Amino-7-(p-chlorophenyl)-5-fluoro-1-isobutyl-2-[...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303866(4-Amino-5-fluoro-7-chloro-1-isobutyl-2-[5-(2-phosp...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303875(4-Amino-5-fluoro-7-(n-propyl)-1-isobutyl-2-[5-(2-p...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303877(4-Amino-7-(4-methylpentyl)-5-fluoro-1-isobutyl-2-[...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303860(4-Amino-5-fluoro-1-isobutyl-2-[5-(2-phosphono)fura...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303867(4-Amino-5-fluoro-7-bromo-1-isobutyl-2-[5-(2-phosph...)
Affinity DataIC50:  130nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303861(4-Amino-5-fluoro-1-(2-ethylbutyl)-2-[5-(2-phosphon...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303873(4-Amino-7-(p-fluorophenyl)-5-fluoro-1-isobutyl-2-[...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303856(4-Amino-5-chloro-1-isobutyl-2-[2-(5-phosphono)fura...)
Affinity DataIC50:  200nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303876(4-Amino-7-(3,3-dimethyl-n-butyl)-5-fluoro-1-isobut...)
Affinity DataIC50:  210nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303868(4-Amino-5-fluoro-6-chloro-1-isobutyl-2-[5-(2-phosp...)
Affinity DataIC50:  225nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303870(4-Amino-7-vinyl-5-fluoro-1-isobutyl-2-[5-(2-phosph...)
Affinity DataIC50:  280nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Rattus norvegicus)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303871(4-Amino-7-cyclopropyl-5-fluoro-1-isobutyl-2-[5-(2-...)
Affinity DataIC50:  350nMAssay Description:Inhibition of rat liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Rattus norvegicus)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303879(4-Amino-5-fluoro-7-[3-(N,N-dimethylamino)propyl]-1...)
Affinity DataIC50:  400nMAssay Description:Inhibition of rat liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303859(4-Amino-7-bromo-1-isobutyl-2-[2-(5-phosphono)furan...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303858(4-Amino-5-bromo-1-isobutyl-2-[2-(5-phosphono)furan...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Rattus norvegicus)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303878(4-Amino-7-(3-hydroxypropyl)-5-fluoro-1-isobutyl-2-...)
Affinity DataIC50:  450nMAssay Description:Inhibition of rat liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303865(4-Amino-5,7-dichloro-1-isobutyl-2-[5-(2-phosphono)...)
Affinity DataIC50:  450nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Rattus norvegicus)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303880(4-Amino-5-fluoro-7-(4-chlorobutyl)-1-isobutyl-2-[5...)
Affinity DataIC50:  500nMAssay Description:Inhibition of rat liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303855(5-(4-amino-5-hydroxy-1-isobutyl-1H-benzo[d]imidazo...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Rattus norvegicus)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303854(5-(4-amino-7-ethyl-5-fluoro-1-isobutyl-1H-benzo[d]...)
Affinity DataIC50:  550nMAssay Description:Inhibition of rat liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Rattus norvegicus)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303875(4-Amino-5-fluoro-7-(n-propyl)-1-isobutyl-2-[5-(2-p...)
Affinity DataIC50:  650nMAssay Description:Inhibition of rat liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303892(4-Amino-5-methoxy-1-isobutyl-2-[5-(2-phosphono)fur...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50277609(CHEMBL507312 | [5-(6-Amino-9-isobutyl-2-methylsulf...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303885(4-Amino-1-cyclopropylmethyl-2-[2-(5-phosphono)fura...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50277565(5-(6-amino-9-neopentyl-9H-purin-8-yl)furan-2-ylpho...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50277565(5-(6-amino-9-neopentyl-9H-purin-8-yl)furan-2-ylpho...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303886(4-Amino-1-cyclobutylmethyl-2-[2-(5-phosphono)furan...)
Affinity DataIC50:  800nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303862(4-Amino-5-fluoro-1-(3-pentyl)-2-[5-(2-phosphono)fu...)
Affinity DataIC50:  850nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Rattus norvegicus)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303861(4-Amino-5-fluoro-1-(2-ethylbutyl)-2-[5-(2-phosphon...)
Affinity DataIC50:  850nMAssay Description:Inhibition of rat liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Rattus norvegicus)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303872(4-Amino-7-phenyl-5-fluoro-1-isobutyl-2-[5-(2-phosp...)
Affinity DataIC50:  900nMAssay Description:Inhibition of rat liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303857(4-Amino-7-chloro-1-isobutyl-2-[2-(5-phosphono)fura...)
Affinity DataIC50:  900nMAssay Description:Inhibition of human liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Rattus norvegicus)
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50303870(4-Amino-7-vinyl-5-fluoro-1-isobutyl-2-[5-(2-phosph...)
Affinity DataIC50:  900nMAssay Description:Inhibition of rat liver FBPase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFructose-1,6-bisphosphatase 1(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50277613(CHEMBL484332 | {5-[6-Amino-9-(3-chloro-2,2-dimethy...)
Affinity DataIC50:  900nMAssay Description:Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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