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Found 181 with Last Name = 'van der aar' and Initial = 'em'
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of human recombinant JAK2More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031743(CHEMBL3360349)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human recombinant JAK2More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50355501(INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031745(CHEMBL3360351 | US10206907, Compound 225)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031760(CHEMBL3360330)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031744(CHEMBL3360350)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032334(CHEMBL3353541)
Affinity DataIC50:  9nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM103727(US10112907, Example 00033 | US10206907, Compound 2...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031738(CHEMBL3360355)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031742(CHEMBL3360348 | US10206907, Compound 59)
Affinity DataIC50:  23nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032340(CHEMBL3353514)
Affinity DataIC50:  25nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM103737(US10206907, Compound 234 | US11000528, Cpd # 11 | ...)
Affinity DataIC50:  27nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031804(CHEMBL3360341)
Affinity DataIC50:  27nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetJak1 protein(Rattus norvegicus)
Galapagos

Curated by ChEMBL
LigandPNGBDBM103727(US10112907, Example 00033 | US10206907, Compound 2...)
Affinity DataIC50:  29nMAssay Description:Inhibition of rat JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032302(CHEMBL3353483)
Affinity DataIC50:  36nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032437(CHEMBL3353533)
Affinity DataIC50:  36nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032438(CHEMBL3353534)
Affinity DataIC50:  40nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031740(CHEMBL3360357 | US10206907, Compound 304)
Affinity DataIC50:  41nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032300(CHEMBL3353485)
Affinity DataIC50:  42nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032305(CHEMBL3353480)
Affinity DataIC50:  44nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032378(CHEMBL3353532)
Affinity DataIC50:  48nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032375(CHEMBL3353530)
Affinity DataIC50:  57nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032341(CHEMBL3353515)
Affinity DataIC50:  63nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032337(CHEMBL3353511)
Affinity DataIC50:  63nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031806(CHEMBL3360343)
Affinity DataIC50:  67nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031747(CHEMBL3360318)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50193995(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Affinity DataIC50:  74nMAssay Description:Inhibition of JAK1 in human whole blood assessed as inhibition of IL-6-induced pSTAT1More data for this Ligand-Target Pair
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032330(CHEMBL3353479)
Affinity DataIC50:  76nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032326(CHEMBL3353475)
Affinity DataIC50:  76nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032370(CHEMBL3353526)
Affinity DataIC50:  85nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032442(CHEMBL3353538)
Affinity DataIC50:  90nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM103728(US10206907, Compound 18 | US11000528, Cpd # 2 | US...)
Affinity DataIC50:  92nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032439(CHEMBL3353535)
Affinity DataIC50:  95nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031802(CHEMBL3360339 | US10206907, Compound 14)
Affinity DataIC50:  103nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032342(CHEMBL3353516)
Affinity DataIC50:  115nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032443(CHEMBL3353539)
Affinity DataIC50:  116nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032279(CHEMBL3353502)
Affinity DataIC50:  118nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032319(CHEMBL3353468)
Affinity DataIC50:  123nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032343(CHEMBL3353517)
Affinity DataIC50:  130nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032444(CHEMBL3353540)
Affinity DataIC50:  138nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031747(CHEMBL3360318)
Affinity DataIC50:  138nMAssay Description:Inhibition of human recombinant JAK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032285(CHEMBL3353498)
Affinity DataIC50:  142nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50438696(CHEMBL2414557)
Affinity DataIC50:  142nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032317(CHEMBL3353466)
Affinity DataIC50:  143nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50031746(CHEMBL3360352)
Affinity DataIC50:  147nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032373(CHEMBL3353528)
Affinity DataIC50:  156nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50438695(CHEMBL2414558)
Affinity DataIC50:  156nMAssay Description:Inhibition of human recombinant JAK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50032322(CHEMBL3353471)
Affinity DataIC50:  158nMAssay Description:Antagonist activity against human FFA2 receptor expressed in HEK293 cells assessed as inhibition of sodium acetate-induced calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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