Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 107751,50420303,50420304,50420305,50420307,107751,50420303,50420304,50420305,50420307   

TargetCyclin-dependent kinase 4(Rabbit)
Astex Therapeutics

US Patent
LigandPNGBDBM50420304(CHEMBL2089065 | US8598217, 165)
Affinity DataIC50: 3nMpH: 7.5Assay Description:A 384-well microtiter Lance TR-FRET (time-resolved-fluorescence energy transfer) endpoint assay was used for CDK4/cyclin D1 kinase activity measureme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2014
Entry Details
US Patent

TargetCyclin-dependent kinase 4(Rabbit)
Astex Therapeutics

US Patent
LigandPNGBDBM107751(CHEMBL2089063 | US8598217, 89)
Affinity DataIC50: 4nMpH: 7.5Assay Description:A 384-well microtiter Lance TR-FRET (time-resolved-fluorescence energy transfer) endpoint assay was used for CDK4/cyclin D1 kinase activity measureme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2014
Entry Details
US Patent

TargetCyclin-dependent kinase 4(Rabbit)
Astex Therapeutics

US Patent
LigandPNGBDBM50420305(CHEMBL2089057 | US8598217, 173)
Affinity DataIC50: 12nMpH: 7.5Assay Description:A 384-well microtiter Lance TR-FRET (time-resolved-fluorescence energy transfer) endpoint assay was used for CDK4/cyclin D1 kinase activity measureme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2014
Entry Details
US Patent

TargetCyclin-dependent kinase 4(Rabbit)
Astex Therapeutics

US Patent
LigandPNGBDBM50420303(CHEMBL2089064 | US8598217, 135)
Affinity DataIC50: 12nMpH: 7.5Assay Description:A 384-well microtiter Lance TR-FRET (time-resolved-fluorescence energy transfer) endpoint assay was used for CDK4/cyclin D1 kinase activity measureme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2014
Entry Details
US Patent

LigandPNGBDBM50420304(CHEMBL2089065 | US8598217, 165)
Affinity DataIC50: 26nMAssay Description:Inhibition of human CDK6/cyclin D3 assessed as inhibition of pRb Ser780 phosphorylation after 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM107751(CHEMBL2089063 | US8598217, 89)
Affinity DataIC50: 49nMAssay Description:Inhibition of human CDK6/cyclin D3 assessed as inhibition of pRb Ser780 phosphorylation after 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50420305(CHEMBL2089057 | US8598217, 173)
Affinity DataIC50: 120nMAssay Description:Inhibition of human CDK6/cyclin D3 assessed as inhibition of pRb Ser780 phosphorylation after 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50420303(CHEMBL2089064 | US8598217, 135)
Affinity DataIC50: 300nMAssay Description:Inhibition of human CDK6/cyclin D3 assessed as inhibition of pRb Ser780 phosphorylation after 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50420307(CHEMBL2089062)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human CDK6/cyclin D3 assessed as inhibition of pRb Ser780 phosphorylation after 30 mins by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM107751(CHEMBL2089063 | US8598217, 89)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human CDK1/cyclin B assessed as inhibition of Tamra-H1 phosphorylation by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50420304(CHEMBL2089065 | US8598217, 165)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of human CDK1/cyclin B assessed as inhibition of Tamra-H1 phosphorylation by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50420307(CHEMBL2089062)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of human CDK1/cyclin B assessed as inhibition of Tamra-H1 phosphorylation by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50420305(CHEMBL2089057 | US8598217, 173)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human CDK1/cyclin B assessed as inhibition of Tamra-H1 phosphorylation by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50420303(CHEMBL2089064 | US8598217, 135)
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human CDK1/cyclin B assessed as inhibition of Tamra-H1 phosphorylation by IMAP-FP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed