Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 31 hits for monomerid = 13597,13814,13815,50142329,50142330,50142335,13597,13814,13815,50142329,50142330,50142335   

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM50142335([(4-{4-Benzotriazol-1-yl-5-[4-(difluoro-phosphono-...)Copy SMILESCopy InChI

Affinity DataIC50: 10nMAssay Description:Inhibitory activity against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM50142335([(4-{4-Benzotriazol-1-yl-5-[4-(difluoro-phosphono-...)Copy SMILESCopy InChI

Affinity DataIC50: 16nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM50142329(({4-[2-Benzotriazol-1-yl-3-[4-(difluoro-phosphono-...)Copy SMILESCopy InChI

Affinity DataIC50: 18nMAssay Description:Inhibitory activity against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM50142330([(4-{2-Benzothiazol-2-yl-2-benzotriazol-1-yl-3-[4-...)Copy SMILESCopy InChI

Affinity DataIC50: 18nMAssay Description:Inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) over-expressed in intact Sf9 cell assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM50142329(({4-[2-Benzotriazol-1-yl-3-[4-(difluoro-phosphono-...)Copy SMILESCopy InChI

Affinity DataIC50: 19nMAssay Description:Inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) over-expressed in intact Sf9 cell assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM50142330([(4-{2-Benzothiazol-2-yl-2-benzotriazol-1-yl-3-[4-...)Copy SMILESCopy InChI

Affinity DataIC50: 20nMAssay Description:Inhibitory activity against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Merck Research Laboratories

LigandBDBM13597(({4-[(4E)-2-(1,3-benzothiazol-2-yl)-2-(1H-1,2,3-be...)Copy SMILESCopy InChI

Affinity DataIC50: 23nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/5/2007
Entry Details Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 2 [V121L](Human)
Merck Frosst Center For Therapeutic Research

LigandBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)Copy SMILESCopy InChI

Affinity DataIC50: 24nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/12/2007
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 1 [V113L,M114V](Human)
Merck Frosst Center For Therapeutic Research

LigandBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)Copy SMILESCopy InChI

Affinity DataIC50: 29nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/12/2007
Entry Details Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 1 [G117E](Human)
Merck Frosst Center For Therapeutic Research

LigandBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)Copy SMILESCopy InChI

Affinity DataIC50: 32nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/12/2007
Entry Details Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)Copy SMILESCopy InChI

Affinity DataIC50: 39nMAssay Description:Inhibition of flag-tagged human PTP1B (1 to 298 residues) catalytic domain expressed in Escherichia coli BL21 cells using fluorescein diphosphate as ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/29/2017
Entry Details Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)Copy SMILESCopy InChI

Affinity DataIC50: 39nMAssay Description:Inhibition of Flag-tagged human PTP1B (1 to 298 residues) expressed in Escherichia coli BL21 using FDP as substrateMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
4/21/2024
Entry Details
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 1 [V113I](Human)
Merck Frosst Center For Therapeutic Research

LigandBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)Copy SMILESCopy InChI

Affinity DataIC50: 39nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/12/2007
Entry Details Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Merck Research Laboratories

LigandBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)Copy SMILESCopy InChI

Affinity DataIC50: 39nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/12/2007
Entry Details Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 1 [M114V](Human)
Merck Frosst Center For Therapeutic Research

LigandBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)Copy SMILESCopy InChI

Affinity DataIC50: 45nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/12/2007
Entry Details Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM13815(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2,5-diphe...)Copy SMILESCopy InChI

Affinity DataIC50: 49nMAssay Description:Inhibitory activity against T cell protein tyrosine phosphataseMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM13815(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2,5-diphe...)Copy SMILESCopy InChI

Affinity DataIC50: 49nMAssay Description:Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)Copy SMILESCopy InChI

Affinity DataIC50: 87nMAssay Description:Inhibition of human TCPTP (1 to 296 residues) catalytic domain expressed in Escherichia coli BL21 cells using fluorescein diphosphate as substrate by...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/29/2017
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)Copy SMILESCopy InChI

Affinity DataIC50: 87nMAssay Description:Inhibition of Flag-tagged human TCPTP (1 to 296 residues) expressed in Escherichia coli BL21 using FDP as substrateMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
4/21/2024
Entry Details
Copy BDB DOIPubMed
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)Copy SMILESCopy InChI

Affinity DataIC50: 87nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/12/2007
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM50142330([(4-{2-Benzothiazol-2-yl-2-benzotriazol-1-yl-3-[4-...)Copy SMILESCopy InChI

Affinity DataIC50: 88nMAssay Description:Inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) over-expressed in intact Sf9 cell assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM13815(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2,5-diphe...)Copy SMILESCopy InChI

Affinity DataIC50: 95nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/12/2007
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Human)
Merck Research Laboratories

LigandBDBM13815(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2,5-diphe...)Copy SMILESCopy InChI

Affinity DataIC50: 109nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/12/2007
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM50142335([(4-{4-Benzotriazol-1-yl-5-[4-(difluoro-phosphono-...)Copy SMILESCopy InChI

Affinity DataIC50: 120nMAssay Description:Inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) over-expressed in intact Sf9 cell assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 1 [L119V](Human)
Merck Frosst Center For Therapeutic Research

LigandBDBM13814(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2-[4-(met...)Copy SMILESCopy InChI

Affinity DataIC50: 142nMpH: 6.3 T: 2°CAssay Description:Hydrolysis of substrate FDP was monitored continuously on a Cytofluor microplate reader with excitation and emission wavelengths set at 440 and 515 ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/12/2007
Entry Details Article
Copy BDB DOIPubMedPDB3D Structure (crystal)
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM50142329(({4-[2-Benzotriazol-1-yl-3-[4-(difluoro-phosphono-...)Copy SMILESCopy InChI

Affinity DataIC50: 190nMAssay Description:Inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) over-expressed in intact Sf9 cell assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetTyrosine-protein phosphatase non-receptor type 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM13815(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2,5-diphe...)Copy SMILESCopy InChI

Affinity DataIC50: 460nMAssay Description:Inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) over-expressed in intact Sf9 cell assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM50142330([(4-{2-Benzothiazol-2-yl-2-benzotriazol-1-yl-3-[4-...)Copy SMILESCopy InChI

Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM50142329(({4-[2-Benzotriazol-1-yl-3-[4-(difluoro-phosphono-...)Copy SMILESCopy InChI

Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM50142335([(4-{4-Benzotriazol-1-yl-5-[4-(difluoro-phosphono-...)Copy SMILESCopy InChI

Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL

TargetReceptor-type tyrosine-protein phosphatase C(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL

LigandBDBM13815(({4-[(4E)-2-(1H-1,2,3-benzotriazol-1-yl)-2,5-diphe...)Copy SMILESCopy InChI

Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory activity against CD45 protein-tyrosine phosphataseMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
11/10/2009
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL