Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 65 hits for monomerid = 26198,50109821,50355403,26198,50109821,50355403   

Target3-phosphoinositide-dependent protein kinase 1(Human)
Merck Research Laboratories

LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataEC50:  1nMAssay Description:Enzyme potency (PDK1 EC50)was determined using recombinant, purified full-length human PDK1 enzyme and AKT-Thr-308-tide as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal flag tagged human JAK2 expressed in baculovirus infected Sf9 cells using biotin-EQEDEPEGDYFEWLE-NH2 as substrate in the pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal flag tagged human TYK2 expressed in baculovirus infected Sf9 cells using biotin-EQEDEPEGDYFEWLE-NH2 as substrate in the pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Tyk2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 1nMAssay Description:Inhibition of protein kinase Jak 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 1nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 1nMAssay Description:Inhibition of human JAK2 (835 to 1132 residues)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Tyrosine kinase 2 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 1nMAssay Description:Inhibition of TYK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 1nMAssay Description:Inhibition of JAK2 (unknown origin) using 35 uM of ATP and Tyr6 peptide by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50355403(CHEMBL261386)
Affinity DataIC50: 2nMAssay Description:Inhibition of JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50355403(CHEMBL261386)
Affinity DataIC50: 3nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 4nMAssay Description:Inhibition of JAK1 (unknown origin) using 87 uM of ATP and Tyr6 peptide by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 4.5nMpH: 7.5 T: 2°CAssay Description:Enzyme assay affinity-purified GST fusions of the active kinase domains (GST-Jak1(866-1154), GST-Jak2(808-1132), GST-Jak3(811-1124) and GST-Tyk2(888-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal flag tagged human JAK3 expressed in baculovirus infected Sf9 cells using biotin-EQEDEPEGDYFEWLE-NH2 as substrate in the pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 5nMAssay Description:Inhibition of protein kinase Jak 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 5nMAssay Description:Inhibition of Tyk2 (unknown origin) using 25 uM of ATP and Tyr3 peptide by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 5nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 5nMpH: 7.5 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit JAK3 RTK activity. The compounds were incubated with enzyme, 10 uM ATP, and ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2008
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 5.20nMpH: 7.5 T: 2°CAssay Description:Enzyme assay affinity-purified GST fusions of the active kinase domains (GST-Jak1(866-1154), GST-Jak2(808-1132), GST-Jak3(811-1124) and GST-Tyk2(888-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2011
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50355403(CHEMBL261386)
Affinity DataIC50: 7nMAssay Description:Inhibition of TYK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 7nMpH: 7.5 T: 2°CAssay Description:Enzyme assay affinity-purified GST fusions of the active kinase domains (GST-Jak1(866-1154), GST-Jak2(808-1132), GST-Jak3(811-1124) and GST-Tyk2(888-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 10nMAssay Description:Inhibition of JAK3 (unknown origin) using 16 uM of ATP and Tyr6 peptide by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 15nMAssay Description:Inhibition of N-terminal flag tagged mouse JAK1 expressed in baculovirus infected Sf9 cells using biotin-EQEDEPEGDYFEWLE-NH2 as substrate in the pres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 15nMAssay Description:Inhibition of mouse JAK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 15nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 15nMAssay Description:Inhibition of JAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 15nMAssay Description:Inhibition of murine Jak 1 protein kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
Merck Research Laboratories

LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 20nMAssay Description:1536-Well TR-Fret uHTS assay PDK1-tide1 peptide substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Merck Research Laboratories

LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 28nMAssay Description:384-Well TR-Fret assay using AKT-tide peptide substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2012
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 41nMpH: 7.5 T: 2°CAssay Description:Enzyme assay affinity-purified GST fusions of the active kinase domains (GST-Jak1(866-1154), GST-Jak2(808-1132), GST-Jak3(811-1124) and GST-Tyk2(888-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2011
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50355403(CHEMBL261386)
Affinity DataIC50: 77nMAssay Description:Inhibition of JAK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2012
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1/2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 160nMAssay Description:Inhibition of mitogen-activated protein kinase ERKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 300nMAssay Description:Inhibition of IKK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 300nMAssay Description:Inhibition of I-kappa-B kinase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMaternal embryonic leucine zipper kinase(Human)
University Of Texas

US Patent
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 330nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent

TargetMaternal embryonic leucine zipper kinase(Human)
University Of Texas

US Patent
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 330nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2019
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 500nMAssay Description:Inhibition of protein kinase FynMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fyn(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 500nMAssay Description:Inhibition of FynT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 600nMAssay Description:Inhibition of JAK1 (unknown origin) using 1 mM of ATP and Tyr6 peptide by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 690nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 900nMAssay Description:Inhibition of JAK3 (unknown origin) using 1 mM of ATP and Tyr6 peptide by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 940nMAssay Description:Inhibition of Fibroblast growth factor receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of protein kinase C alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50109821(CHEMBL21156 | CHEBI:87103 | US10981896, Compound 4...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of JAK2 (unknown origin) using 1 mM of ATP and Tyr6 peptide by Z'-LYTE kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM26198(Jak Inhibitor 1 | CHEMBL21156 | Compound # 2 | 4-t...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
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