Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 41 hits for monomerid = 50097393,50097394,50097395,50097396,50097397,50097398,50097393,50097394,50097395,50097396,50097397,50097398   

TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant BtkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 5.60nMAssay Description:Reversible inhibition of FAM-labeled peptide binding to full-length human N-terminal GST-tagged BTK (2 to 659 residues) expressed in baculovirus infe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetActivin receptor type-1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant ALK2 by LanthaScreen Binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant TNK2 by LanthaScreen Binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant LIMK1 by LanthaScreen Binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataEC50:  28nMAssay Description:Inhibition of BTK autophosphorylation in human Raji cells after 30 mins by Phos-Y223 Btk HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant BmxMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Blk(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 36nMAssay Description:Inhibition of human recombinant BlkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Fgr(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 41nMAssay Description:Inhibition of human recombinant FgrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase FRK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 41nMAssay Description:Inhibition of human recombinant FrkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 54nMAssay Description:Inhibition of human recombinant LynBMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Tec(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 57nMAssay Description:Inhibition of human recombinant TecMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 67nMAssay Description:Inhibition of human recombinant SrcMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 82nMAssay Description:Inhibition of human recombinant LynAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097394(CHEMBL3586446)
Affinity DataEC50:  92nMAssay Description:Inhibition of BTK autophosphorylation in human Raji cells after 30 mins by Phos-Y223 Btk HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 99nMAssay Description:Inhibition of human recombinant HckMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataEC50:  101nMAssay Description:Reversible inhibition of sodium orthovanadate-stimulated BTK autophosphorylation at Tyr223 residues in human Ramos cells preincubated for 2 hrs follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMitogen-activated protein kinase kinase kinase 19(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataKd:  300nMAssay Description:Inhibition of YSK4 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase ITK/TSK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 320nMAssay Description:Inhibition of human recombinant ItkMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 412nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek10(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataKd:  430nMAssay Description:Inhibition of NEK10 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097394(CHEMBL3586446)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to MKK3 (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of Btk (unknown origin) assessed as inhibition of phosphorylation of FAM-labelled peptide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of BTK in human Raji cells after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097393(CHEMBL3586447)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of BTK in human Raji cells after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097396(CHEMBL3586444)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097395(CHEMBL3586445)
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of TIE2 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
University of North Carolina at Chapel Hill

Curated by ChEMBL
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of FGFR3 (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataKd: >1.00E+4nMAssay Description:Inhibition of BMX (unknown origin) assessed as dissociation constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097394(CHEMBL3586446)
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of BTK in human Raji cells after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097397(CHEMBL3586443)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of MKK6 (unknown origin) using [gamma-33P]-ATP after 20 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097396(CHEMBL3586444)
Affinity DataEC50:  2.86E+4nMAssay Description:Inhibition of BTK autophosphorylation in human Raji cells after 30 mins by Phos-Y223 Btk HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of MKK3 (unknown origin) using [gamma-33P]-ATP after 20 mins by radiometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2017
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097398(CHEMBL449216 | HTS-9026)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of Lck (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097397(CHEMBL3586443)
Affinity DataEC50: >5.00E+4nMAssay Description:Inhibition of BTK autophosphorylation in human Raji cells after 30 mins by Phos-Y223 Btk HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097396(CHEMBL3586444)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of BTK in human Raji cells after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097397(CHEMBL3586443)
Affinity DataIC50: 2.40E+5nMAssay Description:Inhibition of BTK in human Raji cells after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM50097395(CHEMBL3586445)
Affinity DataIC50: 8.50E+5nMAssay Description:Inhibition of BTK in human Raji cells after 30 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMed