Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50173536,50173563,50173572,50173576,50173577,50190543,50173536,50173563,50173572,50173576,50173577,50190543   

TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase(Plasmodium falciparum (isolate 3D7))
University of Wales Cardiff

Curated by ChEMBL
LigandPNGBDBM50190543(1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)-te...)
Affinity DataKi:  200nMAssay Description:Inhibition of Plasmodium falciparum dUTPaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase(Plasmodium falciparum (isolate 3D7))
University of Wales Cardiff

Curated by ChEMBL
LigandPNGBDBM50173577(1-{4-Hydroxy-5-[(trityl-amino)-methyl]-tetrahydro-...)
Affinity DataKi:  200nMAssay Description:Inhibitory constant against Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in Escherichia coli BL21 (DE3) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase(Plasmodium falciparum (isolate 3D7))
University of Wales Cardiff

Curated by ChEMBL
LigandPNGBDBM50190543(1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)-te...)
Affinity DataKi:  200nMAssay Description:Inhibition of Plasmodium falciparum dUTPaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase(Plasmodium falciparum (isolate 3D7))
University of Wales Cardiff

Curated by ChEMBL
LigandPNGBDBM50173563(1-{4-Fluoro-5-[(trityl-amino)-methyl]-tetrahydro-f...)
Affinity DataKi:  1.20E+4nMAssay Description:Inhibitory constant against Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in Escherichia coli BL21 (DE3) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50190543(1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)-te...)
Affinity DataKi:  4.60E+4nMAssay Description:Inhibition of human recombinant dUTPaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50190543(1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)-te...)
Affinity DataKi:  4.60E+4nMAssay Description:Inhibition of human dUTPase using dUTP as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed
LigandPNGBDBM50173577(1-{4-Hydroxy-5-[(trityl-amino)-methyl]-tetrahydro-...)
Affinity DataKi:  4.60E+4nMAssay Description:Inhibitory constant against human deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in Escherichia coli BL21 (DE3) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50190543(1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)-te...)
Affinity DataKi:  4.60E+4nMAssay Description:Inhibition of human dUTPaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50190543(1-((2R,4S,5R)-4-hydroxy-5-((tritylamino)methyl)-te...)
Affinity DataKi:  4.60E+4nMAssay Description:Inhibition of recombinant human dUTPase expressed in Escherichia coli BL21 (DE3) using dUTP as substrate by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase(Plasmodium falciparum (isolate 3D7))
University of Wales Cardiff

Curated by ChEMBL
LigandPNGBDBM50173576(CHEMBL364710 | dUTPase inhibitor, 11 | 1-[5-(Benzy...)
Affinity DataKi:  1.11E+5nM ΔG°:  -5.39kcal/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2012
Entry Details Article
PubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase(Plasmodium falciparum (isolate 3D7))
University of Wales Cardiff

Curated by ChEMBL
LigandPNGBDBM50173576(CHEMBL364710 | dUTPase inhibitor, 11 | 1-[5-(Benzy...)
Affinity DataKi:  1.11E+5nMAssay Description:Inhibitory constant against Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in Escherichia coli BL21 (DE3) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase(Plasmodium falciparum (isolate 3D7))
University of Wales Cardiff

Curated by ChEMBL
LigandPNGBDBM50173572(N-[5-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-h...)
Affinity DataKi:  1.78E+5nMAssay Description:Inhibitory constant against Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in Escherichia coli BL21 (DE3) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetPutative deoxyuridine triphosphatase(Leishmania major)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50173577(1-{4-Hydroxy-5-[(trityl-amino)-methyl]-tetrahydro-...)
Affinity DataKi:  3.04E+5nMAssay Description:Inhibitory constant against Leishmania major deoxyuridine 5'-triphosphate nucleotidohydrolaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetDeoxyuridine 5'-triphosphate nucleotidohydrolase(Plasmodium falciparum (isolate 3D7))
University of Wales Cardiff

Curated by ChEMBL
LigandPNGBDBM50173536(1-{4-(tert-Butyl-dimethyl-silanyloxy)-5-[(trityl-a...)
Affinity DataKi:  3.13E+5nMAssay Description:Inhibitory constant against Plasmodium falciparum deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in Escherichia coli BL21 (DE3) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50173572(N-[5-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-h...)
Affinity DataKi:  4.69E+5nMAssay Description:Inhibitory constant against human deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in Escherichia coli BL21 (DE3) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetPutative deoxyuridine triphosphatase(Leishmania major)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50173576(CHEMBL364710 | dUTPase inhibitor, 11 | 1-[5-(Benzy...)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibitory constant against Leishmania major deoxyuridine 5'-triphosphate nucleotidohydrolaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50173576(CHEMBL364710 | dUTPase inhibitor, 11 | 1-[5-(Benzy...)
Affinity DataKi:  1.00E+6nM ΔG°:  -4.09kcal/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2012
Entry Details Article
PubMed
TargetPutative deoxyuridine triphosphatase(Leishmania major)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50173572(N-[5-(2,4-Dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-3-h...)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibitory constant against Leishmania major deoxyuridine 5'-triphosphate nucleotidohydrolaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetPutative deoxyuridine triphosphatase(Leishmania major)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50173563(1-{4-Fluoro-5-[(trityl-amino)-methyl]-tetrahydro-f...)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibitory constant against Leishmania major deoxyuridine 5'-triphosphate nucleotidohydrolaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetPutative deoxyuridine triphosphatase(Leishmania major)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50173536(1-{4-(tert-Butyl-dimethyl-silanyloxy)-5-[(trityl-a...)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibitory constant against Leishmania major deoxyuridine 5'-triphosphate nucleotidohydrolaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50173563(1-{4-Fluoro-5-[(trityl-amino)-methyl]-tetrahydro-f...)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibitory constant against human deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in Escherichia coli BL21 (DE3) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50173576(CHEMBL364710 | dUTPase inhibitor, 11 | 1-[5-(Benzy...)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibitory constant against human deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in Escherichia coli BL21 (DE3) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
LigandPNGBDBM50173536(1-{4-(tert-Butyl-dimethyl-silanyloxy)-5-[(trityl-a...)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibitory constant against human deoxyuridine 5'-triphosphate nucleotidohydrolase expressed in Escherichia coli BL21 (DE3) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetdCTP deaminase(Campylobacter jejuni subsp. jejuni)
Instituto De Parastiologia Y Biomedicina "Lopez-Neyra

LigandPNGBDBM50173576(CHEMBL364710 | dUTPase inhibitor, 11 | 1-[5-(Benzy...)
Affinity DataKi:  1.00E+9nM ΔG°:  0kcal/molepH: 8.0 T: 2°CAssay Description:Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/25/2012
Entry Details Article
PubMed