Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50259131,50310435,50310436,50310438,50310428,50310430,50310431   

TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(CHEMBL466517 | JNJ-26990990 | N-((Benzo[b]thien-3-...)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetSodium channel protein type 2 subunit alpha(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(CHEMBL466517 | JNJ-26990990 | N-((Benzo[b]thien-3-...)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibition of rat Nav1.2 channel expressed in chinese hamster CHL1610 cells at preconditioning pulse of -67 mV after 2 to 3 mins by whole-cell patch-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(CHEMBL466517 | JNJ-26990990 | N-((Benzo[b]thien-3-...)
Affinity DataIC50:  1.33E+5nMAssay Description:Inhibition of rat Cav2.2 channel expressed in 0.07 Hz frequency-stimulated HEK cells by whole-cell patch-clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 1(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(CHEMBL466517 | JNJ-26990990 | N-((Benzo[b]thien-3-...)
Affinity DataIC50:  2.50E+4nMAssay Description:Inhibition of carbonic anhydrase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(CHEMBL466517 | JNJ-26990990 | N-((Benzo[b]thien-3-...)
Affinity DataIC50:  1.10E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310438(CHEMBL1086777 | N-[(5-methyl-1-benzothien-3-yl)met...)
Affinity DataIC50:  4.50E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310430(CHEMBL1084919 | N-[(4-bromo-1-benzothien-3-yl)meth...)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310431(CHEMBL1084918 | N-[(5-fluoro-1-benzothien-3-yl)met...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50259131(CHEMBL466517 | JNJ-26990990 | N-((Benzo[b]thien-3-...)
Affinity DataIC50:  6.60E+4nMAssay Description:Inhibition of human carbonic anhydrase 2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310435(CHEMBL1084920 | N-[(5-bromo-1-benzothien-3-yl)meth...)
Affinity DataIC50:  1.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310436(CHEMBL1084675 | N-[(5-chloro-1-benzothien-3-yl)met...)
Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed

TargetCarbonic anhydrase 2(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50310428(CHEMBL1088204 | rac-N-[1-(1-benzothien-3-yl)ethyl]...)
Affinity DataIC50:  1.30E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 by CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed