Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 81299,81306,81308,81309,213825,50214606,81299,81306,81308,81309,213825,50214606   

TargetPutative lanosterol 14-alpha-demethylase(Leishmania infantum)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM213825(VNI)
Affinity DataKd:  2nMAssay Description:Binding affinity to Leishmania infantum CYP51 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi (strain CL Brener))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM213825(VNI)
Affinity DataKd:  8.30nMAssay Description:Binding affinity to Trypanosoma cruzi Y CYP51A expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
Target1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50214606(Azole, 12 | CHEMBL253613 | 4'-chloro-biphenyl-4-ca...)
Affinity DataIC50: 15nMAssay Description:Inhibition of CYP24 in human keratinocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi (strain CL Brener))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM213825(VNI)
Affinity DataKd:  15nMpH: 7.4 T: 2°CAssay Description:Briefly, the reaction mixture contained 1 uM CYP51, 2 uM cytochrome P450 reductase, 100 uM dilauroyl-alpha-phosphatidylcholine, 0.4 mg/ml isoctrate d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2017
Entry Details Article
PubMed
TargetLanosterol 14-alpha-demethylase(Trypanosoma brucei brucei (strain 927/4 GUTat10.1))
Vanderbilt University

LigandPNGBDBM50214606(Azole, 12 | CHEMBL253613 | 4'-chloro-biphenyl-4-ca...)
Affinity DataKd:  40nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2011
Entry Details Article
PubMed
TargetLanosterol 14-alpha-demethylase(Trypanosoma brucei brucei (strain 927/4 GUTat10.1))
Vanderbilt University

LigandPNGBDBM81299(Azole, 4)
Affinity DataKd:  50nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2011
Entry Details Article
PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi (strain CL Brener))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM81299(Azole, 4)
Affinity DataKd:  70nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2011
Entry Details Article
PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi (strain CL Brener))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50214606(Azole, 12 | CHEMBL253613 | 4'-chloro-biphenyl-4-ca...)
Affinity DataKd:  70nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2011
Entry Details Article
PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi (strain CL Brener))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM81308(Azole, 20)
Affinity DataKd:  70nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2011
Entry Details Article
PubMed
TargetLanosterol 14-alpha-demethylase(Trypanosoma brucei brucei (strain 927/4 GUTat10.1))
Vanderbilt University

LigandPNGBDBM81309(Azole, 17)
Affinity DataKd:  80nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2011
Entry Details Article
PubMed
TargetLanosterol 14-alpha-demethylase(Trypanosoma brucei brucei (strain 927/4 GUTat10.1))
Vanderbilt University

LigandPNGBDBM81308(Azole, 20)
Affinity DataKd:  90nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2011
Entry Details Article
PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi (strain CL Brener))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM81306(Azole, 11)
Affinity DataKd:  110nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2011
Entry Details Article
PubMed
TargetSterol 14-alpha demethylase(Trypanosoma cruzi (strain CL Brener))
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM81309(Azole, 17)
Affinity DataKd:  110nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2011
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Yeast)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM213825(VNI)
Affinity DataIC50: 250nMAssay Description:Inhibition of Candida albicans CYP51 assessed as reduction in [3-3H]lanosterol 14alpha-demethylation preincubated for 60 secs followed by NADPH addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2020
Entry Details Article
PubMed
TargetLanosterol 14-alpha demethylase(Yeast)
Vanderbilt University School of Medicine

Curated by ChEMBL
LigandPNGBDBM213825(VNI)
Affinity DataKd:  290nMAssay Description:Binding affinity to Candida albicans CYP51 by spectral titration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2020
Entry Details Article
PubMed
Target25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial(Human)
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50214606(Azole, 12 | CHEMBL253613 | 4'-chloro-biphenyl-4-ca...)
Affinity DataIC50: 616nMAssay Description:Inhibition of CYP27B1 in human keratinocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetLanosterol 14-alpha-demethylase(Trypanosoma brucei brucei (strain 927/4 GUTat10.1))
Vanderbilt University

LigandPNGBDBM81306(Azole, 11)
Affinity DataKd:  710nMpH: 6.0Assay Description:Azole derivatives used as an inhibitor of TB and TC CYP51.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2011
Entry Details Article
PubMed