Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 33 hits for monomerid = 92900,92903,50049254,50375814,50375815,235689,235688   

TargetNitric oxide synthase, brain(Human)
The University of Texas

LigandBDBM92900(CHEMBL1835117 | L-Arginine, 2 | NMMA, 2)Copy SMILESCopy InChI

Affinity DataKi:  2.00E+3nMAssay Description:Inhibition assay using DDAH-1 and nNOS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseChEBI
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TargetArginase-1(Bovine)
Christian-Albrechts-University of Kiel

Curated by ChEMBL

LigandBDBM50375814(CHEMBL260628)Copy SMILESCopy InChI

Affinity DataKi:  1.71E+4nMAssay Description:Inhibition of bovine liver arginaseMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLPC cidPC sid

In DepthDetails ArticlePubMed
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TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Christian-Albrechts-University

LigandBDBM235689(hDDAH inhibitor, 2c)Copy SMILESCopy InChI

Affinity DataKi:  5.80E+4nM ΔG°:  -6.01kcal/molepH: 7.4 T: 37°CAssay Description:A colorimetric assay was carried out in 150 μL 50 mM potassium phosphate buffer pH 7.4 containing 4 μg of recombinant hDDAH-1 and varying c...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPurchasePC cidPC sid

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TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Christian-Albrechts-University

LigandBDBM235688(hDDAH inhibitor, 2b)Copy SMILESCopy InChI

Affinity DataKi:  9.00E+4nM ΔG°:  -5.74kcal/molepH: 7.4 T: 37°CAssay Description:A colorimetric assay was carried out in 150 μL 50 mM potassium phosphate buffer pH 7.4 containing 4 μg of recombinant hDDAH-1 and varying c...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchasePC cidPC sid

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TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Christian-Albrechts-University

LigandBDBM92900(CHEMBL1835117 | L-Arginine, 2 | NMMA, 2)Copy SMILESCopy InChI

Affinity DataKi:  1.31E+5nMAssay Description:Inhibition assay using DDAH-1 and nNOS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseChEBI
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TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Christian-Albrechts-University

LigandBDBM92900(CHEMBL1835117 | L-Arginine, 2 | NMMA, 2)Copy SMILESCopy InChI

Affinity DataKi:  2.90E+5nMAssay Description:Inhibition assay using DDAH-1 and nNOS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseChEBI
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TargetNitric oxide synthase, brain(Rat)
The University of Texas

LigandBDBM92903(L-Citrulline, 4)Copy SMILESCopy InChI

Affinity DataKi: >1.00E+6nMAssay Description:Inhibition assay using DDAH-1 and nNOS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGMMDBPC cidPC sidPDBSimilars

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TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Christian-Albrechts-University

LigandBDBM92900(CHEMBL1835117 | L-Arginine, 2 | NMMA, 2)Copy SMILESCopy InChI

Affinity DataKi:  1.20E+6nMAssay Description:Inhibition assay using DDAH-1 and nNOS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseChEBI
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TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Christian-Albrechts-University

LigandBDBM92900(CHEMBL1835117 | L-Arginine, 2 | NMMA, 2)Copy SMILESCopy InChI

Affinity DataKi:  1.40E+6nMAssay Description:Inhibition assay using DDAH-1 and nNOS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

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TargetNitric oxide synthase, inducible(Human)
University of California

Curated by ChEMBL

LigandBDBM50049254((2S)-2-amino-5-(N-methylcarbamimidamido)pentanoic ...)Copy SMILESCopy InChI

Affinity DataKi:  1.40E+6nMAssay Description:Binding affinity towards inducible nitric oxide synthaseMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoChEBI
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In DepthDetails ArticlePubMed
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TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Christian-Albrechts-University

LigandBDBM92903(L-Citrulline, 4)Copy SMILESCopy InChI

Affinity DataKi:  3.70E+6nMAssay Description:Inhibition assay using DDAH-1 and nNOS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseChEBI
DrugBankKEGGMMDBPC cidPC sidPDBSimilars

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TargetNitric oxide synthase, endothelial(Human)
Christian-Albrechts-University of Kiel

Curated by ChEMBL

LigandBDBM50375815(CHEMBL408088)Copy SMILESCopy InChI

Affinity DataIC50:  4.00E+6nMAssay Description:Inhibition of human recombinant eNOS by griess assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
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Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetNitric oxide synthase, inducible(Human)
University of California

Curated by ChEMBL

LigandBDBM50375815(CHEMBL408088)Copy SMILESCopy InChI

Affinity DataIC50:  5.00E+6nMAssay Description:Inhibition of human recombinant iNOS by griess assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetNitric oxide synthase, brain(Human)
The University of Texas

LigandBDBM50375814(CHEMBL260628)Copy SMILESCopy InChI

Affinity DataIC50:  3.00E+6nMAssay Description:Inhibition of human recombinant nNOS by griess assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sid

In DepthDetails ArticlePubMed
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TargetArginase-1(Bovine)
Christian-Albrechts-University of Kiel

Curated by ChEMBL

LigandBDBM50375814(CHEMBL260628)Copy SMILESCopy InChI

Affinity DataIC50:  1.23E+5nMAssay Description:Inhibition of bovine liver arginaseMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADGoogleScholar

Ligand InfoCHEMBLPC cidPC sid

In DepthDetails ArticlePubMed
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TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Christian-Albrechts-University

LigandBDBM50375815(CHEMBL408088)Copy SMILESCopy InChI

Affinity DataIC50: >5.00E+6nMAssay Description:Inhibition of human recombinant DDAH1 expressed in Escherichia coli BL21 cellsMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetNitric oxide synthase, inducible(Human)
University of California

Curated by ChEMBL

LigandBDBM50049254((2S)-2-amino-5-(N-methylcarbamimidamido)pentanoic ...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+7nMAssay Description:Inhibition of human recombinant iNOS by griess assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoChEBI
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TargetNitric oxide synthase, inducible(Human)
University of California

Curated by ChEMBL

LigandBDBM50375814(CHEMBL260628)Copy SMILESCopy InChI

Affinity DataIC50:  2.40E+6nMAssay Description:Inhibition of human recombinant iNOS by griess assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sid

In DepthDetails ArticlePubMed
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TargetNitric oxide synthase, brain(Human)
The University of Texas

LigandBDBM50375815(CHEMBL408088)Copy SMILESCopy InChI

Affinity DataIC50:  7.90E+6nMAssay Description:Inhibition of human recombinant nNOS by griess assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

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TargetNitric oxide synthase, brain(Human)
The University of Texas

LigandBDBM92900(CHEMBL1835117 | L-Arginine, 2 | NMMA, 2)Copy SMILESCopy InChI

Affinity DataIC50:  950nMAssay Description:Inhibition of human recombinant nNOS expressed in Sf9 cells assessed as inhibition of conversion of [3H]-L-arginine to [3H]-L-citrulline after 45 min...More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLPC cidPC sidSimilars

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TargetNitric oxide synthase, endothelial(Human)
Christian-Albrechts-University of Kiel

Curated by ChEMBL

LigandBDBM92900(CHEMBL1835117 | L-Arginine, 2 | NMMA, 2)Copy SMILESCopy InChI

Affinity DataIC50:  650nMAssay Description:Inhibition of human recombinant eNOS expressed in Sf9 cells assessed as inhibition of conversion of [3H]-L-arginine to [3H]-L-citrulline after 45 min...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetNitric oxide synthase, endothelial(Human)
Christian-Albrechts-University of Kiel

Curated by ChEMBL

LigandBDBM50375814(CHEMBL260628)Copy SMILESCopy InChI

Affinity DataIC50:  2.00E+6nMAssay Description:Inhibition of human recombinant eNOS by griess assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sid

In DepthDetails ArticlePubMed
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TargetNitric oxide synthase, brain(Human)
The University of Texas

LigandBDBM50049254((2S)-2-amino-5-(N-methylcarbamimidamido)pentanoic ...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+7nMAssay Description:Inhibition of human recombinant nNOS by griess assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoChEBI
CHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
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TargetNitric oxide synthase, endothelial(Human)
Christian-Albrechts-University of Kiel

Curated by ChEMBL

LigandBDBM50049254((2S)-2-amino-5-(N-methylcarbamimidamido)pentanoic ...)Copy SMILESCopy InChI

Affinity DataIC50: >1.00E+7nMAssay Description:Inhibition of human recombinant eNOS by griess assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoChEBI
CHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
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TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Christian-Albrechts-University

LigandBDBM50049254((2S)-2-amino-5-(N-methylcarbamimidamido)pentanoic ...)Copy SMILESCopy InChI

Affinity DataIC50: >5.00E+6nMAssay Description:Inhibition of human recombinant DDAH1 expressed in Escherichia coli BL21 cellsMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoChEBI
CHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
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TargetNitric oxide synthase, inducible(Human)
University of California

Curated by ChEMBL

LigandBDBM92900(CHEMBL1835117 | L-Arginine, 2 | NMMA, 2)Copy SMILESCopy InChI

Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human recombinant iNOS expressed in Sf9 cells assessed as inhibition of conversion of [3H]-L-arginine to [3H]-L-citrulline after 45 min...More data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
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Ligand InfoPurchaseChEBI
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TargetNitric oxide synthase, endothelial(Human)
Christian-Albrechts-University of Kiel

Curated by ChEMBL

LigandBDBM50049254((2S)-2-amino-5-(N-methylcarbamimidamido)pentanoic ...)Copy SMILESCopy InChI

Affinity DataIC50:  5.90E+3nMAssay Description:Inhibitory activity against human Endothelial nitric oxide synthaseMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoChEBI
CHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
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TargetNitric oxide synthase, brain(Human)
The University of Texas

LigandBDBM50049254((2S)-2-amino-5-(N-methylcarbamimidamido)pentanoic ...)Copy SMILESCopy InChI

Affinity DataIC50:  1.00E+4nMAssay Description:Inhibitory activity against human Neuronal nitric oxide synthaseMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoChEBI
CHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
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TargetNitric oxide synthase, inducible(Human)
University of California

Curated by ChEMBL

LigandBDBM50049254((2S)-2-amino-5-(N-methylcarbamimidamido)pentanoic ...)Copy SMILESCopy InChI

Affinity DataIC50:  1.40E+4nMAssay Description:Inhibitory activity against human inducible nitric oxide synthaseMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoChEBI
CHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
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TargetNitric oxide synthase, inducible(Mouse)
Université

Curated by ChEMBL

LigandBDBM50049254((2S)-2-amino-5-(N-methylcarbamimidamido)pentanoic ...)Copy SMILESCopy InChI

Affinity DataIC50:  2.50E+4nMAssay Description:Compound was evaluated for inhibitory activity against iNOS obtained from RAW 264.7 cells.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankGoogleScholar

Ligand InfoChEBI
CHEMBLPC cidPC sidPatentsSimilars

In DepthDetails ArticlePubMed
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TargetNitric oxide synthase, brain(Human)
The University of Texas

LigandBDBM92900(CHEMBL1835117 | L-Arginine, 2 | NMMA, 2)Copy SMILESCopy InChI

Affinity DataAssay Description:Inhibition assay using DDAH-1 and nNOS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Christian-Albrechts-University

LigandBDBM92900(CHEMBL1835117 | L-Arginine, 2 | NMMA, 2)Copy SMILESCopy InChI

Affinity DataAssay Description:Inhibition assay using DDAH-1 and nNOS.More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLPC cidPC sidSimilars

In DepthDetails ArticlePubMed
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TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Human)
Christian-Albrechts-University

LigandBDBM50375814(CHEMBL260628)Copy SMILESCopy InChI

Affinity DataIC50: >5.00E+6nMAssay Description:Inhibition of human recombinant DDAH1 expressed in Escherichia coli BL21 cellsMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoCHEMBLPC cidPC sid

In DepthDetails ArticlePubMed
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