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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
6
hits in this display
Target
Aldo-keto reductase family 1 member B10
(Human)
Gifu Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50394657
(CHEMBL270067)
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Affinity Data
Ki: 15nM
Assay Description:
Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde redu...
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Target Info
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Target
DNA polymerase beta
(Rat)
Tokyo University of Science
Curated by
ChEMBL
Ligand
BDBM50109030
(4-(3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopen...)
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Affinity Data
Ki: 4.70E+3nM
Assay Description:
Inhibition constant of the compound was determined at a concentration of 5 microM on rat DNA polymerase beta as a function of template primer dose
More data for this Ligand-Target Pair
Target Info
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MMDB
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KEGG
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B.MOAD
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Target
DNA polymerase beta
(Rat)
Tokyo University of Science
Curated by
ChEMBL
Ligand
BDBM50109030
(4-(3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopen...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 6.60E+3nM
Assay Description:
Inhibition constant of the compound was determined at a concentration of 10 microM on rat DNA polymerase beta as a function of nucleotide substrate c...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
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KEGG
UniProtKB/SwissProt
B.MOAD
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Ligand Info
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CHEMBL
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PC sid
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In Depth
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Article
PubMed
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Target
Aldo-keto reductase family 1 member B10
(Human)
Gifu Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50394657
(CHEMBL270067)
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Copy InChI
Affinity Data
IC50: 27nM
Assay Description:
Inhibition of recombinant human intestinal N-terminal 6-His-tagged AKR1B10 expressed in Escherichia coli BL21 (DE3) pLysS cells using pyridine-3-alde...
More data for this Ligand-Target Pair
Target Info
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antibodypedia
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CHEMBL
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Article
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Target
Aldo-keto reductase family 1 member B1
(Human)
Gifu Pharmaceutical University
Curated by
ChEMBL
Ligand
BDBM50394657
(CHEMBL270067)
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Affinity Data
IC50: 6.90E+3nM
Assay Description:
Inhibition of recombinant human AKR1B1 using pyridine-3-aldehyde as substrate by fluorescence assay
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
antibodypedia
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CHEMBL
KEGG
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In Depth
Details
Article
PubMed
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Target
DNA polymerase beta
(Rat)
Tokyo University of Science
Curated by
ChEMBL
Ligand
BDBM50109030
(4-(3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopen...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.10E+4nM
Assay Description:
Inhibitory effect of the compound on the activity of rat DNA polymerase beta was determined by inhibitory dose curves
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI